Annual Report 2012 - Acino

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ACINO | OUR TECHNOLOGIES
Technologies
• Suspension/solution layering
• Extrusion/spheronization
• In addition all common process
technologies
Key products
• Oxycodone MUPS
• Hydromorphone capsules
• Omeprazol
• Isosorbitdinitrat (ISDN)
• Artequin
Selected development projects
• Oxycodone matrix
• Ferrous sulfate
R&D focus (pellets)
• Optimization of the pellet shape
• Improvement of the hardness
• Better filling performance and
flowability
R&D and manufacturing sites
• Aesch BL, Switzerland
• Liesberg, Switzerland
Acino offers a unique range of
solid oral formulations
Acino is a top player when it comes to pellet technologies. With expertise in a multitude
of technology platforms, Acino offers an unparalleled range of solid dosage forms:
Pellets with modified release of the active ingredient are the basis of a variety of oral drug
formulations. They can be compressed to form MUPS (Multiple Unit Particulate Systems)
or filled into capsules or stick packs. MUPS display a superimposed drug release profile:
after intake they dissolve into a multitude of subunits which are ultimately responsible for
the release of the active ingredient in a second step. Acino’s particular strength is its
expertise in developing and manufacturing MUPS with a high drug content. Pellets composed
of different active ingredients and/or release rates can also easily be blended
offering a nearly unlimited flexibility to tailor a drug regimen.
Microtablets, prepared from powder or granulates, are an excellent addition to the pelletbased
product range. Filled into capsules or stick packs, they allow for an exact and flexible
dosage titration, are easy to handle and countable per unit. The option to mix microtablets
of different active ingredients (without substance interference) further increases the flexibility
to create customized medicines.
Oral dispersible films/tablets are loaded with an active ingredient and are suitable for
application to the oral cavity. The active ingredient is dissolved or suspended in the polymer
matrix. Oral dispersibles can be easily administered without liquids. Patients benefit
from a rapid onset of action thanks to a quick dissolution of the films/tablets. The buccal
absorption may increase bioavailability of active ingredients with a high first pass effect.
A multitude of coating and packaging technologies provides additional possibilities to
enhance the product profile. Coatings in various forms can be applied to modify the
release of the active ingredient, facilitate swallowability, mask odor and taste, or improve
the visual appearance.
Even the best formulations can still be improved. Acino is continuously enhancing its technologies
to provide even higher product quality, distinctly shorter processing times and
cost savings.