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Key notes on plastic surgery/Adrian M. Richards

Key notes on plastic surgery/Adrian M. Richards

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1<br />

30 GENERAL PRINCIPLES<br />

• Avascular necrosis (AVN)<br />

• Shortening<br />

• Damage to adjacent structures.<br />

B<strong>on</strong>e graft healing<br />

B<strong>on</strong>e grafts heal by the following mechanisms.<br />

Incorporati<strong>on</strong><br />

• This is adherence of the graft to the host tissue.<br />

• Incorporati<strong>on</strong> is maximized in immobilized, well-vascularized tissue.<br />

Osseoc<strong>on</strong>ducti<strong>on</strong><br />

• The b<strong>on</strong>e graft acts as a scaffold al<strong>on</strong>g which vessels and osteoprogenitor cells<br />

travel.<br />

• Old b<strong>on</strong>e is absorbed as new is deposited.<br />

• This process is also known as creeping substituti<strong>on</strong>.<br />

Osseoinducti<strong>on</strong><br />

• This is the differentiati<strong>on</strong> of mesenchymal cells within the local tissue into<br />

osteocytes.<br />

• Osteoclasts, osteoblasts and osteocytes within the b<strong>on</strong>e graft are not capable of<br />

mitosis.<br />

• The increased numbers of these cells within the b<strong>on</strong>e graft are derived from the<br />

mesenchymal tissue of the recipient site.<br />

• Osseoinducti<strong>on</strong> is c<strong>on</strong>trolled by b<strong>on</strong>e morphogenic proteins (BMPs).<br />

Osteogenesis<br />

• This is the formati<strong>on</strong> of new b<strong>on</strong>e by surviving cells within the b<strong>on</strong>e graft.<br />

• It is the predominant mechanism by which new b<strong>on</strong>e is formed in vascularized<br />

b<strong>on</strong>e grafts.<br />

• Osteogenesis does not occur to a significant degree in n<strong>on</strong>-vascularized b<strong>on</strong>e grafts.<br />

Survival of b<strong>on</strong>e grafts<br />

Factors influencing the survival of b<strong>on</strong>e grafts can be divided into three groups:<br />

(i) systemic factors; (ii) intrinsic graft factors; and (iii) factors relating to the placement<br />

of the graft.<br />

Systemic factors<br />

These are similar to those affecting wound healing and include:<br />

• Age<br />

• Nutriti<strong>on</strong><br />

• Immunosuppressi<strong>on</strong><br />

• Drugs<br />

• Diabetes<br />

• Obesity.

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