July 16, 2012 - Department of Anesthesiology - Duke University

Monday, July 16, 2012 • Volume 14, Issue 28 

Acadesine Does not Improve Outcomes 

of Open Heart Surgery, Though Safety of 

Operation has Improved 

(July 10, 2012 - Insidermedicine) 

A drug designed to protect the heart 

during heart bypass surgery does 

not reduce risk of serious events, 

stroke or death, though the surgery 

itself has become much safer, 

according to a report published 

in the Journal of the American 

Medical Association. 

Newman MF, Ferguson TB, 

White JA, Ambrosio G, Koglin 

J, Nussmeier NA, Pearl RG, 

Pitt B, Wechsler AS, Weisel RD, 

Reece TL, Lira A, Harrington 

RA; RED-CABG Steering 

Committee and Investigators. 

Effect of adenosine-regulating 

agent acadesine on morbidity 

and mortality associated with 

coronary artery bypass grafting: the RED-CABG randomized 

controlled trial. JAMA. 2012 Jul 11;308(2):157-64. 

Here is some information about coronary artery bypass grafting (CABG): 

• It is used to treat severe coronary heart disease, in which plaque has 

built up inside the arteries and blocked blood flow to the heart 

• During the operation, a healthy artery is attached to the blocked one, 

creating an alternate route for blood to reach the heart 

• It is the most common type of open heart surgery in the US 

Researchers from Duke University Medical Center studied over 3,000 

CABG patients randomized to receive either the regulating agent, 

Acadesine, or a placebo during their operation. Acadesine was designed 

to improve blood flow and perfusion and protect the heart during bypass 

surgery. 

After one month, researchers found that patients taking Acadesine had 

no reduced risk of stroke, serious events or death: 5% of patients had 

a severe event following the procedure, regardless of if they took the 

drug or placebo. The researchers note, however, that a 5% complication 

rate was significantly lower than what was expected, an aspect that 

demonstrates great improvements in the surgery safety. 

We spoke with Dr. Mark Newman, PI of the study, who offered some further 

insight. “Today’s research finds that the regulating agent Acadesine does 

not improve outcomes for CABG patients, though the surgery itself has 

become much safer.” 

Full article and video here: http://tinyurl.com/727afox 

© 2009, CEH Inc. 

http://anesthesiology.duke.edu 

Comings and Goings 

News 

New Research Publications 

Honjo, K., R.Y. Hwang, and W.D. Tracey, 

Optogenetic manipulation of neural circuits and 

behavior in Drosophila larvae. Nat. Protocols, 

2012. 7(8): p. 1470-1478. 

Please welcome Karthik Raghunathan, MD, Assistant Professor to the 

department. Dr. Raghunathan’s primary appointment is with the VA but 

will be helping out with Duke North OR’s and Liver Transplants. Dr. 

Raghunathan started on July 15, 2012. 

We wish a fond farewell and good luck to Bo Wang, Visiting Scholar. Bo, 

who worked in the Basic Science Division, left the department on June 

30, 2012. 

Leaving the department soon? Let’s keep in touch! Please contact Lauren 

Marcilliat at lauren.marcilliat@duke.edu with your new mailing and email address 

prior to your departure so that we can add you to our database! 

Anesthesiology on Facebook and Twitter 

Do you have exciting news or information 

pertinent to the academic community 

that you want to share through the 

department’s social media sites? The 

department has facebook and twitter 

accounts for Duke Anesthesiology, Duke 

Anesthesiology Alumni, and the DREAM 

Campaign. Send your announcements to 

Lauren Marcilliat (lauren.marcilliat@duke. 

edu) to be posed on the department’s social media sites. Remember to 

keep announcements to 140 characters in length so that they are twitter 

compatible (about the size of this sentence). Including a link to another 

online source for more information is highly recommended. 

Like us on Facebook at 

http://www.facebook.com/DukeAnes 

Hyperbaric Grand Rounds 

Thursday, July 19, 2012 | 5 pm | HBO Conference 

Room, White Zone, Duke South 

“SCUBA THERAPY: IMAGINE THE 

POSSIBILITIES” 

Jim Elliott, Founder/President, Diveheart & Diveheart 

Military Wounded (DMW) 

1

THIS MONTH IN THE DEPARTMENT OF ANESTHESIOLOGY 

July 2012 

MONDAY TUESDAY WEDNESDAY THURSDAY FRIDAY 

16 17 18 19 20 

7:15-8:00 am, RM203-Pain 

Clinic 

MRC Pain Conference 

2:30-3:30 pm, VAMC 

VA Echocardiography 

Conference 

5-6:30 pm, 5685-HAFS 

Executive Team Meeting 

5-6 pm, 5685-HAFS 

CT Conference: “Aortic Surgery 

and Stroke: Advances in 

Neuromonitoring” - Dr. Miklos 

Kertai 

7:00 am, 2001DN 

Grand Rounds: “Personal 

Cardiovascular Risk Factor 

Modification” - Michael Blazing, 

MD & John Guyton, MD 

4:30 pm, 5685-HAFS 

Advanced Resident 

Lecture: “TBA” 

- J. Mauricio del Rio, MD 

7:15-8:00 am, RM203-Pain 

Clinic 

MRC Pain Journal Club 

4-5 pm, 5680A-HAFS 

Pediatric Conference 

23 24 25 26 27 

7:15-8:00 am, RM203-Pain 

Clinic 


2:30-3:30 pm, VAMC 


Conference 

5-6 pm, 5685-HAFS 

CT Conference 

IRB Deadline 

7:00 am, 2001DN 

Grand Rounds: “Chemical 

Dependence in Anesthesiology: 

Preventive Measures” 

- Warren Pendergast, MD & 

Catherine Kuhn, MD 

4:30 pm, 5685-HAFS 


Lecture: “Neuroanesthesia 

Emergencies” 

- David McDonagh, MD 

7:15-8:00 am, RM203-Pain 

Clinic 


4-5 pm, 5680A-HAFS 


5-6 pm, 5685-HAFS 

Fellow Seminar Series: “Personalities, 

Learning, Teaching, 

Teams, and Conflict” - Peter 

Metzner, MA & Mark 

Stafford-Smith, MD 

30 31 August 1, 2012 2 3 

7:15-8:00 am, RM203-Pain 

Clinic 


2:30-3:30 pm, VAMC 


Conference 

5-6 pm, 5685-HAFS 

CT Conference 

IRB Deadline 

7:00 am, 2001DN 

Grand Rounds: “Welcome 

to The WiPPP: Workflows in 

Personal and Professional 

Productivity” - Jeffrey Taekman, 

MD 

4:30 pm, 5685-HAFS 


Lecture: “Malignant Hyperthermia: 

Genetics, Diagnosis and 

Treatment” 

- Scott Schulman, MD 

7:15-8:00 am, RM203-Pain 

Clinic 


4-5 pm, 5680A-HAFS 


6 7 8 9 10 

7:15-8:00 am, RM203-Pain 

Clinic 


2:30-3:30 pm, VAMC 


Conference 

5-6 pm, 5685-HAFS 

Faculty Meeting 

6-7:30 pm, 5685-HAFS 

Executive Team Meeting 

5-6 pm, 5685-HAFS 

CT Conference 

IRB Deadline 

7:00 am, 2001DN 

Grand Rounds 

4:30 pm, 5685-HAFS 


Lecture 

7:15-8:00 am, RM203-Pain 

Clinic 


4-5 pm, 5680A-HAFS 


Upcoming: 

2012 Duke Anesthesiology Alumni Reception: Sunday, October 14, 2012 | Washington, DC 

2012 ASA: October 13-17, 2012 | Washington, DC 

2012 Duke Anesthesiology Holiday Party: Saturday, December 1, 2012 | Cotton Room at Golden Belt | Downtown Durham, NC 

http://anesthesiology.duke.edu 2

Grant Overview 

The DREAM Innovation Grant (DIG) supports 

innovative high-risk, and potentially high-reward 

investigations to accelerate anesthesia and pain 

management research. 

Research deemed innovative may introduce a new 

paradigm, challenge current paradigms, look at 

existing problems from new perspectives, or exhibit 

other uniquely creative qualities. The DIG promotes 

new ideas; therefore, proposals need not include 

preliminary data. However, a solid rationale for the 

work must be provided. Proposed work should not 

be the next logical step of previous work, but should 

have a high probability of revealing new avenues 

of investigation. This program aims to provide pilot 

funding that will lead to successful competition for 

additional funding beyond the pilot period. The 

research concept, scientific team, and explicit plans 

for how this work will lead to follow-on funding will be 

the primary criteria for judging. These points should 

be specifically addressed in the application. 

The principal investigator (PI) is responsible for 

clearly and explicitly articulating the project’s 

innovation and the potential impact on anesthesia 

and pain management research. 

Eligibility: Faculty level appointment with in the 

Department of Anesthesiology 

One of the grants will be reserved to support a 

beginning scientist (within 5 years of completion 

of residency or fellowship) by encouraging and 

adequately funding projects that can contribute to 

bridging the gap between training and progression to 

independent investigator status. The other award(s) 

will be used as a seed grant to help investigators with 

promising science obtain preliminary data to support 

follow-on funding applications. 

ANESTHESIOLOGY NEWS 

DREAM Innovation Grant (DIG) 

Funding 

A maximum of $30,000 will be awarded to each 

recipient. None of the funds awarded are to pay for 

faculty salary or overhead expenses. The number of 

grant recipients and grant amount will be determined 

by the DREAM Innovation Grant Committee after all 

applications have been received. 

Application and Deadline 

Applications and questions should be submitted to 

David S. Warner, M.D. at david.warner@duke.edu. 

A Statement of Intent (Deadline July 16, 2012): 

a. Abstract (150 word max) 

b. Budget (Budgets should not include salary 

support for a faculty, resident, or fellow) 

c. NIH formatted Biosketch for PI 

2. NIH R03-like Application Format (Hard Deadline 

September 7, 2012): i.e., up to 1 page for Specific 

Aims and up to 6 pages for the research plan 

(background, preliminary data and/or rationale, 

experimental plan, description of roles of scientific 

team members, timeline for milestones and 

completion, and definition of plans to advance work 

beyond this funding interval). All pages are to be 

single-spaced in 11 point Arial font. Appendices will 

not be considered. 

Final applications must be submitted in a pdf format 

and include the final abstract, budget, biosketches of 

key personnel, specific aims, and research plan. 

3. Winners will be announced October 14, 2012 

during the ASA Alumni Reception. 

http://anesthesiology.duke.edu 3



To View More Pictures, 

Like us on Facebook at 

http://www.facebook.com/DukeAnes 

4

Classifieds 

CAR FOR SALE: 2007 Toyota Camry LE, 2.4L, 66000 miles, mint condition, price 

below KBB-quick sale - $12,500 (Morrisville) Automatic, 4 wheel ABS, A/C, power 

windows, power locks, power steering, tilt wheel, cruise control, AM FM radio with 

CD player, dual air bags, side air bags, power seats, steel wheels, carfax history 

available. Photos at https://picasaweb.google.com/104934085738812154729/ 

ToyotaCamry2007 If interested, please contact - kk178@dm.duke.edu or Ph 206- 

669-4595. 

LAB EQUIPMENT FOR SALE: GEM PREMIER 4000 blood gas analyzer. Price 

negotiable. If interested, please contact Ike at keita.ikeda@duke.edu. 



HOUSE FOR RENT: Newly renovated oceanfront/oceanview 

house at Carolina Beach. 6 

Bedrooms, 4 Baths. Only $2150/week for members 

of department. If interested, send email 

to allison.ross@duke.edu for more information. 

Will be ready for renters June 9th. 

HOUSE FOR SALE: 5 BR * 3 BATH * 3010 SF 

* $555,000 

Simply put, this home has it all. Located in Forest 

Hills and overlooking the park, 608 E. Forest 

Hills Boulevard offers both the comforts of a 

newer home and the charm of a historic neighborhood. 

Inside, cathedral ceilings, expansive 

windows, and skylights grace the living room, 

and gleaming hardwood floors run throughout 

the home. Ample kitchen cabinet space, granite counter tops, stainless steel appliances, 

and a breakfast bar bring ease and comfort to cooking any meal. Maximize 

your time outside with the generous outdoor living spaces: the rocking-chair front 

porch, screened back porch, and the large, stone patio overlooking the private 

backyard. Located in the Morehead Montessori priority zone, this home is also 

generator-ready, has a water recirculator, and has an in-home surround sound 

speaker system. Courtney James * Urban Durham Realty * 919.291.2318 

BEACH HOUSE RENTAL: Price: $2300/week linens 

and furnishings included. 

http://web.mac.com/bford71/Brad_and_Neil/the_ 

Sandpiper/the_Sandpiper.html 

Fresh From The Farm 

If you are interested in purchasing any of 

the farm fresh items listed below, please 

contact danielle.carr@duke.edu for payment 

and drop-off arrangements (All 

items are first come, first served, i.e. limited 

supply). 

EGGS @$2.50 dozen (brown and blue eggs) 

ROSEMARY @$1.00 bunch 

BASIL @$2.00 per sandwich bag 

THYME @$1.00 bunch 

POTATO @$2.50 per pound 

ONIONS @$1.00 per pound (white, yellow, red) 

TOMATO @$1.00 per pound (salad, grape, heirloom) 

Upcoming CME Activities 

7th Annual Winter Anesthesia and Critical Care Review 

March 3-8, 2013 | Canyons Resort | Park City, UT 

For more information, contact Kathy Long: kathy.long@duke.edu. 

6th Annual Emerging Technologies in the OR and Great Fluid 

Debate 

June 10-14, 2013 

Disney’s Grand Floridian Resort & Spa | Lake Buena Vista, FL 

For more information, email Katherine Siler: siler006@mc.duke.edu. 

16th Annual Cardiothoracic Update and TEE Board Review 

June 20-23, 2013 

The Westin Hilton Head Island Resort and Spa | Hilton Head Island, SC 

For more information, contact Jaime C. Cooke: jca24@notes.duke.edu. 

Preceptorships 

Ultrasound Guided Regional Anesthesia Preceptorship Course 

2012-2013 Dates Available | Duke University Medical Center, Durham, NC 

For more information, email Katherine Siler: siler006@mc.duke.edu. 

Participants in the Duke Preceptorship will spend three days in the regional block 

area, operating rooms and on the floor with post surgery patients observing ultrasound 

guided single shot nerve blocks and catheter techniques in a wide variety 

of clinical scenarios. 

Visiting Preceptorship in Intraoperative 

Transesophageal Echocardiography 

2012-2013 Dates Available | Duke University Medical Center, Durham, NC 

For more information, email Jaime C. Cooke: jca24@notes.duke.edu. 

Participants in the Duke Intraoperative TEE Preceptorship spend one three-day 

session in the cardiac operating suites, observing techniques of intraoperative 

TEE and interpretation of images. 

For more information and to register, visit 


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July 16, 2012 - Department of Anesthesiology - Duke University

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