Congenital hyperinsulinism - Swiss Society of Neonatology

Fig. 5
A B
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Focal adenomatous hyperplasia: within the lesion, the ß
cells are hyperactive, with enlarged cytoplasm and a large
Golgi region full of proinsulin but relatively few insulin
granules and little insulin labelling because the lesion
hypersecretes but does not store insulin (A: HE stain, B:
immunohistochemistry staining for proinsulin).