AKT SIGNALING P A THW A Y - BioNova
AKT SIGNALING P A THW A Y - BioNova
AKT SIGNALING P A THW A Y - BioNova
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ORDERING<br />
Translational Initiation<br />
Apoptosis<br />
Growth Factor RTK<br />
Bax<br />
p53<br />
MDM2<br />
BIM<br />
BCL2<br />
p53<br />
Degradation<br />
Integrin<br />
FKH2<br />
Cytokine Receptor<br />
CREB<br />
GPCR<br />
PI3K GBP GTP<br />
GAB(A)R<br />
PI3K1<br />
FAK PI3K<br />
IRS-1 Gab1 ILK<br />
Gab2<br />
Paxillin<br />
JAK1 PI3K<br />
PTEN<br />
BCAP<br />
SYK LYN<br />
Synaptic<br />
Signaling<br />
PTEN<br />
PIP3<br />
PIP2<br />
DEPTOR<br />
PIP3<br />
Membrane<br />
mTOR<br />
Recruitment<br />
PRR5<br />
Rictor<br />
PDK1 & Activation<br />
PTEN<br />
<strong>AKT</strong><br />
Membrane Sin1<br />
Recruitment &<br />
Activation<br />
PIP5K<br />
AS160<br />
Glut4 Glucose Import<br />
Glucose Transport<br />
PPA2<br />
Huntington Neuroprotection<br />
RPS6<br />
PDK1<br />
eNOS<br />
Cardiovascular<br />
Homeostasis<br />
S6<br />
ATAXIN<br />
14-3-3<br />
Aggregation &<br />
Neurodegeneration<br />
P70S6K<br />
PDCD4<br />
4EBP1<br />
GBL Raptor<br />
PFKFB2 Glycolysis<br />
mTOR<br />
ATG13<br />
DEPTOR<br />
<strong>AKT</strong><br />
Laminin A Organization<br />
of Nuclear Protein<br />
Autophagy PRAS40<br />
RAF1<br />
Apoptosis XIAP<br />
Ras<br />
FOXO1<br />
MEK 1/2 Gene<br />
Transcription<br />
Cytoplasm<br />
Nucleus<br />
GBL<br />
NPAT GATA4 NFKB<br />
CD19<br />
PI3K<br />
MDM2<br />
β−Catenin<br />
p27<br />
BAD<br />
GSK3B<br />
Wee<br />
IKKα<br />
14-3-3<br />
p27<br />
IKB<br />
IKB<br />
CREB<br />
Cyclin D1<br />
MYT1<br />
NFKB<br />
Survival<br />
Genes<br />
NFAT<br />
Cell<br />
Cycle<br />
Kinases Phosphotases Transcription Factors Prosurvival Enzyeme<br />
Ag<br />
Cell Proliferation<br />
AR<br />
BCR<br />
Cell Survival<br />
For research purposes only.<br />
Prices subject to change.<br />
Not for use in humans.<br />
<strong>AKT</strong> <strong>SIGNALING</strong> PA<strong>THW</strong>AY<br />
The <strong>AKT</strong> signaling pathway plays an important regulatory role in many cellular survival pathways,<br />
primarily as an inhibitor of apoptosis. <strong>AKT</strong> also plays a regulatory role in angiogenesis and metabolism.<br />
The <strong>AKT</strong> pathway is activated by factors that induce PI3K which in turn activates mTOR pathways. These<br />
pathways function in the inhibition of apoptosis as well as cell differentiation and cell cycle. <strong>AKT</strong> signaling<br />
has been implicated in various cancers and is an active area of interest for anti-cancer therapeutics.<br />
GAB(A)R<br />
Synaptic<br />
Signaling<br />
Translational Initiation<br />
Apoptosis<br />
Growth Factor RTK<br />
RPS6<br />
IRS-1 Gab1<br />
Gab2<br />
PDCD4<br />
Cytoplasm<br />
Nucleus<br />
p53<br />
<strong>AKT</strong><br />
S6<br />
P70S6K<br />
4EBP1<br />
Apoptosis<br />
Bax<br />
MDM2<br />
PI3K1<br />
ATG13<br />
GBL Raptor<br />
mTOR<br />
DEPTOR<br />
XIAP<br />
FOXO1<br />
BCL2<br />
BIM<br />
Integrin<br />
PRAS40<br />
FKH2<br />
PI3K<br />
Paxillin<br />
MDM2<br />
Cytokine Receptor<br />
BAD<br />
14-3-3<br />
CREB<br />
JAK1<br />
PIP2<br />
PTEN<br />
PIP3<br />
DEPTOR<br />
mTOR<br />
PRR5<br />
PTEN<br />
Rictor<br />
Membrane Sin1<br />
Recruitment &<br />
Activation<br />
PDK1<br />
Autophagy<br />
p53<br />
Degradation<br />
FAK<br />
ILK<br />
Survival<br />
Genes<br />
PDK1<br />
CREB<br />
PI3K<br />
GBL<br />
<strong>AKT</strong><br />
β−Catenin<br />
NFAT<br />
GPCR<br />
PI3K GBP GTP<br />
PPA2<br />
PTEN<br />
PIP3<br />
Membrane<br />
Recruitment<br />
& Activation<br />
GSK3B<br />
NPAT GATA4 NFKB<br />
p27<br />
Cyclin D1<br />
CD19<br />
PI3K<br />
PIP5K<br />
Kinases Phosphotases Transcription Factors Prosurvival Enzyeme<br />
AS160<br />
Huntington<br />
Wee<br />
Cell<br />
Cycle<br />
BCAP<br />
eNOS<br />
ATAXIN<br />
PFKFB2<br />
Laminin A<br />
p27<br />
SYK<br />
MYT1<br />
Ag<br />
14-3-3<br />
IKB<br />
Cell Proliferation<br />
AR<br />
LYN<br />
BCR<br />
Glut4 Glucose Import<br />
Glucose Transport<br />
RAF1<br />
Neuroprotection<br />
Cardiovascular<br />
Homeostasis<br />
Glycolysis<br />
Aggregation &<br />
Neurodegeneration<br />
Organization<br />
of Nuclear Protein<br />
IKKα<br />
Ras<br />
MEK 1/2 Gene<br />
Transcription<br />
IKB<br />
NFKB<br />
Cell Survival
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<strong>AKT</strong>1 (4D6) Antibody<br />
NBP2-01724<br />
Flow cytometric<br />
analysis of Jurkat<br />
cells, using<br />
NBP2-01724.<br />
Species: Hu, Mu, Rt, Ca, Mk<br />
Applications: WB, FACS, IF, IHC-P<br />
Park7 (DJ-1) Antibody<br />
NB300-270<br />
Immunocytochemical<br />
analysis in human<br />
cortex using<br />
NB300-270.<br />
Species: Hu, Mu, Rt, Bv, Ch, SyHa, Ze<br />
Applications: WB, ICC, IF, In vitro, IP<br />
TAZ Antibody<br />
NB110-58359<br />
Species: Hu, Mu, Rt<br />
Applications: WB, ICC, IF, IP<br />
WNK4 Antibody<br />
NB600-284<br />
Species: Hu, Mu, Rt<br />
Applications: WB<br />
Immunocytochemical<br />
analysis in HepG2<br />
cells using<br />
NB110-58359.<br />
Western blot<br />
analysis in<br />
mouse kidney<br />
lysate using<br />
NB600-284.<br />
<strong>AKT</strong>1 [p Ser473] Antibody<br />
NB600-590<br />
Immunoflourescent<br />
analysis in<br />
cardiomyocytes<br />
infected with<br />
adenovirus using<br />
Species: Hu<br />
Applications: WB, ELISA, ICC, IF, IHC-P<br />
PDK1 Antibody<br />
NB100-2384<br />
Western blot<br />
analysis of<br />
human heart<br />
lysate using<br />
NB100-2384.<br />
Species: Hu, Mu, Rt, Bv, Ch, Mk, Po, Ze<br />
Applications: WB<br />
VPS34 Antibody<br />
NB110-87320<br />
Species: Hu, Mu, Rt, Po<br />
Applications: WB, ICC, IF<br />
YAP1 Antibody<br />
NB110-58358<br />
NB600-590.<br />
Immunocytochemical<br />
analysis<br />
in HeLa<br />
cells using<br />
NB110-87320.<br />
Immunocytochemical<br />
analysis in<br />
HeLa cells using<br />
NB110-58358.<br />
Species: Hu<br />
Applications: WB, ICC, IF, IHC-P, IP<br />
MAP2K1IP1/MAPKSP1 Antibody<br />
NBP1-50631<br />
Immunohistochemical<br />
analysis in mouse<br />
lung using<br />
NBP1-50631.<br />
Species: Hu, Mu<br />
Applications: WB, ICC, IF, IHC-P<br />
ROBLD3 Antibody<br />
NBP1-71687<br />
Species: Hu, Mu<br />
Applications: ICC, IF, IHC-P<br />
WNK1 Antibody<br />
NB600-225<br />
Species: Hu, Mu, Rt<br />
Applications: WB<br />
YB1 Antibody<br />
NBP1-97572<br />
Immunohistochemical<br />
analysis in<br />
human renal<br />
cell carcinoma using<br />
NBP1-71687.<br />
Western blot<br />
analysis in<br />
F-11 cell<br />
lysate using<br />
NB600-225.<br />
Immunohistochemical<br />
analysis in<br />
in mouse testis<br />
using NBP1-97572.<br />
Species: Hu, Mu, Rt<br />
Applications: WB, ICC, IHC-P, IP<br />
<strong>AKT</strong> Antibodies<br />
Name Catalog# Clonality Species Application<br />
<strong>AKT</strong>1 NB600-467 Polyclonal Hu, Mu, Rt, Ch WB, ELISA, IF, IHC-P<br />
<strong>AKT</strong>1 (4D6) NBP2-01724 Monoclonal Hu, Mu, Rt, Ca, Mk WB, FACS, IF, IHC-P<br />
<strong>AKT</strong>1 [p Ser473] NB600-590 Polyclonal Hu, Mu, Rt WB, IP<br />
<strong>AKT</strong>2 NBP1-61800 Polyclonal Hu, Mu, Rt WB, ELISA, IHC<br />
<strong>AKT</strong>2 NBP1-26594 Polyclonal Hu WB, IP<br />
<strong>AKT</strong>2 (1B6) NBP1-51603 Monoclonal Hu, Rt, Mk WB, ELISA, IF<br />
<strong>AKT</strong>3 NBP1-03025 Polyclonal Hu, Mu WB, IHC-P<br />
<strong>AKT</strong>3 NBP1-80900 Polyclonal Hu WB, IF, IHC-P<br />
<strong>AKT</strong>3 (9H8) NBP1-47658 Monoclonal Hu, Mu WB, IF, IHC, IHC-P<br />
<strong>AKT</strong>1/2/3 NBP1-62077 Polyclonal Hu, Mu, Rt WB, ELISA, IHC<br />
pan <strong>AKT</strong> NBP1-20183 Polyclonal Mu WB, IHC-Fr, IHC-P<br />
PI3K and mTOR Antibodies<br />
Name Catalog# Clonality Species Application<br />
mTOR NB100-240 Polyclonal Hu, Rt ICC, IP, PLA<br />
mTOR [p Ser2448] NB600-607 Polyclonal Hu WB, ELISA, IHC-P<br />
mTOR (F11) NBP2-00217 Monoclonal Hu, Mu WB, IHC-P, IP<br />
PI 3 Kinase p85 alpha NBP1-61781 Polyclonal Hu, Mu, Rt WB, ELISA, IF, IHC-P<br />
PI 3 Kinase p85 beta NB100-65590 Monoclonal Hu, Mu, Rt, Bv, Mk WB, IHC-Fr, IP<br />
PI 3 Kinase p85 beta NBP1-41066 Polyclonal Hu WB, IP<br />
PI 3 Kinase p110 delta NB600-1062 Polyclonal Hu WB, ELISA, ICC<br />
PI 3 Kinase catalytic<br />
subunit gamma NB100-1097 Polyclonal Hu IHC, PEP-ELISA<br />
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Popular <strong>AKT</strong> Signaling Pathway Antibodies<br />
Name Catalog# Clonality Species Application<br />
Bad (Y208) NB200-615 Monoclonal Hu, Mu, Rt WB, FACS, ICC, IHC-P, IP<br />
BRF1 NBP1-66314 Polyclonal Hu, Mu WB, ELISA, IF, IHC<br />
BRF2 NBP1-88355 Polyclonal Hu WB, IHC-P<br />
CRMP2 NBP1-61771 Polyclonal Hu, Mu, Rt WB, ELISA, IF, IHC<br />
DDIT4 NBP1-85211 Polyclonal Hu WB, IF, IHC-P<br />
eNOS NB300-500 Polyclonal Hu, Mu, Rt, Bv, Ca, Po WB, IHC-Fr, IHC-P<br />
FKBP5/FKBP51 NB100-68240 Polyclonal Hu WB, IHC-P, IP<br />
FOXO1A NBP1-19825 Polyclonal Hu, Mu WB, IF, IHC-P<br />
FOXO3A NB100-613 Polyclonal Hu WB, IP, PLA<br />
FOXO4 NBP1-61744 Polyclonal Hu, Mu WB, ELISA, IF<br />
GSK3 alpha/beta (1H8) NB110-85523 Monoclonal Hu, Mu, Rt, Bv, Ca,<br />
Mk, Po, Rb, Sh WB, IHC-P, IP<br />
Huntingtin NBP1-03377 Polyclonal Mu, Rt WB, IF, IHC-Fr, IHC-P<br />
INPPL1 NB100-1592 Polyclonal Hu WB, IHC-P, IP<br />
MAP2K1IP1/MAPKSP1 NBP1-50631 Polyclonal Hu, Mu WB, ICC, IF, IHC-P<br />
MDM2 NBP1-02158 Polyclonal Hu, Mk WB<br />
GSK3 beta NB100-91797 Polyclonal Hu, Mu, Rt WB, IHC-P<br />
NDRG2 NBP1-81424 Polyclonal Hu WB, IF, IHC-P<br />
NDRG3 NBP1-86034 Polyclonal Hu WB, IHC-P<br />
nNOS NBP1-39681 Polyclonal Hu WB, ICC, IF, IHC-P, IP<br />
NUR77 NB100-56745 Polyclonal Hu, Mu WB, ICC, IF<br />
Park7(DJ-1) NB300-270 Polyclonal Hu, Mu, Rt, Bv,<br />
Ch, SyHa, Ze WB, ICC, IF, In vitro, IP<br />
PDK1 NB100-2384 Polyclonal Hu, Mu, Rt, Bv,<br />
Ch, Mk, Po, Ze WB<br />
PHLPP NB100-1811 Polyclonal Hu, Mu WB, IHC-P, IP<br />
PHLDA3 NBP1-80683 Polyclonal Hu WB, IF, IHC-P<br />
PI4KB/PI4KIII beta NBP2-12814 Polyclonal Hu WB, IP<br />
PRAS40 NBP1-61317 Polyclonal Hu, Mu, Rt WB, ELISA, IHC<br />
Protein Kinase D2 (5G1) NBP2-02984 Monoclonal Hu, Rt, Ca, Mk WB, IF, IHC<br />
Protein Kinase D2 NB100-637 Polyclonal Hu WB, IHC-P, IP<br />
PTEN NB100-2229 Polyclonal Hu, Mu WB, IHC-P, IP<br />
RanBP3 NB100-74647 Polyclonal Hu, Mu WB, IF, IP, PLA<br />
ROBLD3 NBP1-71687 Polyclonal Hu, Mu ICC, IF, IHC-P<br />
RRAGB NBP1-85801 Polyclonal Hu WB, IF, IHC-P<br />
RSK1 [p Ser380] NB120-5777 Polyclonal Hu, Mu, Rt WB<br />
SGK3 NBP1-80760 Polyclonal Hu WB, IHC-P<br />
Synaptotagmin 1 NBP1-61218 Polyclonal Hu, Mu, Rt WB, ELISA, IHC<br />
TAZ NB110-58359 Polyclonal Hu, Mu, Rt WB, ICC, IF, IP<br />
THEM4 NBP1-77360 Polyclonal Hu, Mu, Rt WB, ELISA, IHC-P<br />
TSC1 NB100-80855 Polyclonal Hu, Mu WB, IHC-P<br />
TSC2 [Thr1462] NBP1-19954 Polyclonal Hu, Mu, Rt IHC-P<br />
VPS34 NB110-87320 Polyclonal Hu, Mu, Rt, Po WB, ICC, IF<br />
WNK1 NB600-225 Polyclonal Hu, Mu, Rt WB<br />
WNK4 NB600-284 Polyclonal Hu, Mu, Rt WB<br />
YAP1 NB110-58358 Polyclonal Hu WB, ICC, IF, IHC-P, IP<br />
YB1 NBP1-97572 Polyclonal Hu, Mu, Rt WB, ICC, IHC-P, IP
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