Structural, Spectral, Biological and Electrochemical Studies Of Some ...

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Electrochemical studies of thirty-six complexes and single crystal XRD investigation of two N-N-S, donor ligands and three complexes were accomplished. 1.5 Concluding remarks An extensive literature survey is made on the versatile properties of thiosemicarbazones. Studies showed that these thiosemicarbazones have antibacterial, antiviral and antiproliferative properties and hence used against tuberculosis, leprosy, psoriasis, rheumatism, trypanosomiasis and coccidiosis. Certain thiosemicarbazones showed a selective inhibition of HSV and HIV infections. The extreme insolubility of most thiosemicarbazones in water causes difficulty in the oral administration in clinical practice. The nature of the substituent attached at 4N influences the biological activity, while the acid character of the 2NH allows the ligand to be anionic or neutral. Transition metal complexes are found to have more activity than uncombined thiosemicarbazones. They exhibit a variety of denticity and can be varied by proper substitution. The stereochemistry assumed by the thiosemicarbazones during coordination with transition metal ions depends on the factors such as preparative conditions and availability of additional bonding site in the ligand moiety and charge ofthe ligand. The resulting complexes exhibited a wide range of stereo chemistries and have biomimic activity and potential application as sensors. 12
References 1. D. L. Klayman, J. F. Bartosevic, T. S. Griffin, C. J. Mason, J. P. Scovill, 1. Med. Chem., 1979,22,855 and references therein. 2. D. K. Demertzi, A. Domopoulou, M. A. Demertzis, G.. Valle, A. J. Papageorgiou, 1. Inorg. Biochem, 1997, 68, 147. 3 J.C.Logan, M.P. Fox, J.H.Morgan, A. M. Makohon, C .J. Pfau,1. Gen. Viroli, 1975,28,271. 4 N. N. Durham, R. W. Chesnut, D. F. Haslam, K. D. Berlin, N. N. Durham and D. E. Kiser, Molecular Pathology ofDisease, 1974, 4, 77. 5. S. P. Mittal, S. K. Shanna, R.V. Singh, J. P. Tandon, Curr. Sci., 1981,50,483 and the references therein. 6 D. X.West, S.B.Padhye, P.S. Sonawane, Transition Met. Chem., 1991, 18, 101. 7 D. Horton, R. G. Nickol and O. Varela, Carbohydr. Res., 1987, 168,295. 8. S. K. Jain, B. S. Garg and Y. K. Bhoon, Transition Met. Chem., 1986,11,89. 9 S. Mariotto, L. Cuzzolin, A. Adami, P. Del Soldato. H. Suzuki, G.;Benoni, Brit.1. Pharmacol. 1995,114, 1105. 10. R.H.U. Borges, E. Paniago and H. Beraldo, 1. Inorg. Biochem., 1997, 65, 268. 11 A. Nicolaou, C. Waterfield, S..Kenyon, W. Gibbons, E. Kepper, Eur. 1. Biochem. 1997,244,8876. 12. A.S Dobek, D.L. Klayman, E.J. Jr. Dickson, J.P. Scovill and E.C. Tramont, Antimicrob. Agents Chemother., 1980,18, 27. 13 R. W. Byrnes, M. Mohan, W. E. Antholine, R. X. Xu and D. H. Petering, Biochemistry, 1990, 29, 7046. 14. J. G. Joshi, M. Dhar, M. Clauberg, V. Chauthaiwale,. Environ.Health Perspect. 1994,102, 207. 15 A. Dyaz, I. Garcya, R. Cao, H. Beraldo, M. M. Salberg, D.X West, L. Gonzalez, E. Ochoa, Polyhedron, 1997, 61, 3555. 13
Page 3 and 4: Declaration Certificate Acknowledge
Page 5 and 6: Chapter3. 40 SPECTRAL, ELECTROCHEMI
Page 7 and 8: 5.2 Experimental 116 5.2.1 Material
Page 9 and 10: Chapter8 173 SPECTRAL, BIOLOGICAL (
Page 11: PREFACE The work embodied in this t
Page 14 and 15: Recently radionuclides have attract
Page 16 and 17: thione thiol Fig 1.1 The existence
Page 18 and 19: thiol equilibrium which in turn is
Page 20: g)/mL. Since then, several workers
Page 26 and 27: (Hexahydroazepine-4-thiocarboxylic
Page 28 and 29: an additional 22 minutes. The cryst
Page 30 and 31: Fig. 2.4 Structuralformula oJH2SAP
Page 32 and 33: 2.6.5. NMR spectra IH and 13C NMR s
Page 34 and 35: that the condensation reaction is i
Page 42: ·r.hle 2." 11-1 NMR assignments fo
Page 46 and 47: Table.2.7 Selected bond lengths [A]
Page 48 and 49: thione S in a molecule on one side
Page 50 and 51: Table 2.8. Crystal data andstructur
Page 52 and 53: Cs point group. The unit cell conta
Page 54 and 55: 2.10 Concluding remarks. Synthesize
Page 56 and 57: Chapter 3 SPECTRAL, ELECTROCHEMICAL
Page 59 and 60: 3.2 Experimental 3.2. JMaterials Th
Page 61 and 62: Azido[ I-H-morpholine-I-thiocarbohy
Page 64 and 65: complexes indicate that they are ma
Page 66: indication of sulphur coordination
Page 69 and 70: The perchlorate complex 9 shows a s
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gfactors were quoted relative to th
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Fig 3.3(d) EPR spectra in polycryst
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Fig 3.3g EPR spectra in solution st
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Table 3.S.b Orbital reduction param
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complexes of thiosemicarbazones ind
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The synthesized N-N-S ligands and t
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"·able.3.7 Microbial studies ofN-N
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3.6 Concluding remarks According to
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18 P. Bindu, M. R. P. Kurup.T. R. S
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53 54 55 56 57 58 59 60 61 62. 63 6
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In recent years considerable intere
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·.......... Analytical data. condu
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Table 4.2 Selected IR bands (crn")
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4.4.4 EPR spectra The EPR spectra o
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Fig 4.2c EPR spectra ofcopper compl
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the metal ion can easily be found b
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"'.ble4.7 Antimicrobiall studies of
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110 activity ofthe complexes and li
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the minerals carnotite [K2(U02)2(V0
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observations generated sufficient i
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118 by thiocyanate anion as confirm
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Fig 5.4 EPR spectra ofvanadyl compl
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Fig 5.5 Experimentalia) and Simulat
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core. Ofthe two VI-N bonds generate
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References M. E. Weeks and H. M. Le
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137 solution of potassium thiocyana
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indicating the existence of two typ
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tetrahedral. Complexes with nitrate
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6.7 Concluding remarks 151 The N-N-
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those of Parkinson's disease. Due t
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157 With O-N-S donors coordination
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Fig 7.4 EPR spectra ofmanganese com
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7.6 X-ray diffraction studies of bi
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viz, thiolate sulphur (SI) and pyri
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References D. Evans K. S. Hallwood
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Chapter 8 SPECTRAL, BIOLOGICAL (STR
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methanol and ether and dried in vac
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Mainly because of the solubility pr
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8.6 X-ray diffraction studies of [N
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The selected crystals of compound 4
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187 In the cation Ni(II) displays p
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References M. A. Halcrow and G. Chr
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Chapter 9 Zn(II) COMPLEXES WITH TRI
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This Chapter describes the synthese
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aromatic ring are found between 0 7
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Table 9.4 lH NMR assignments ofN-N-
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vice versa. There is no diagonal sp
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9.5 Concluding remarks Bacillussp.
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analyses, magnetic susceptibility,
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egion. The profile of its voltammog
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