Structural, Spectral, Biological and Electrochemical Studies Of Some ...

Fig. 2.4 Structuralformula oJH2SAP
A solution 1 g, (5.52 mmol) of 4-methyl-4-phenyl-3-thiosemicarbazide, .in 5 mL of
methanol was treated with 392 mg (5.52 mmol) of pyrrolidine and 678 mg (5.52
mmol) of 2-salicylaldehyde. The solution was heated at reflux for 20 minutes. The
solution was chilled and the crystals that separated were collected and washed well
with methanol. This afforded 1.35 g (65%) of pale yellow rods of N-pyrrolidine-2­
[1-(2-hydroxy) benzylidene] hydrazine carbothioamide), H2SAP. Fig. 2.4. The
compound was recrystallised from absolute ethanol, mp 166°C.
Synthesis of 2-hydroxyacetophenone- 4N -pyrrolidine thiosemicarbazones, H2APP
A solution 1 g (5.52 mmol) of 4-methyl-4-phenyl-3-thiosemicarbazide.in 5 mL of
methanol was treated with 392 mg (5.52 mmol) of pyrrolidine and 664 mg (5.52
mmol) of 2-hydroxyacetophenone. The solution was heated at reflux for 20 minutes.
The solution was chilled and the crystals that separated were collected and washed
well with
Fig. 2.5 StructuralJormula ofH2APP
methanol. This afforded 1.35 g (65%) of pale yellow rods of 2­
hydroxyacetophenone- 3N -pyrrolidine thiosemicarbazones, H 2APP Fig. 2.5. The
compound was recrystallised from absolute ethanol, mp 178°C.
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