Neonatal Unconjugated Hyperbilirubinemia

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Bilirubin Synthesis There There is increased production of bilirubin in the newborn because of: Increased rate of degradation A shortened circulating erythrocyte life span (70-90 (70 90 days versus 120 days) of an increased mass A very large pool of hematopoietic tissue that ceases to function shortly after birth resulting in heme degradation An increased turnover of cytochromes (nonhemoglobin heme proteins) An increase in enterohepatic circulation
Binding and Transport <strong>Unconjugated</strong> <strong>Unconjugated</strong> bilirubin is quickly bound to albumin in the serum Newborns Newborns have reduced albumin concentrations and consequently a lower plasma binding capacity for bilirubin There There is consequently more free bilirubin in the serum It It is the free bilirubin that is believed to cause neurological damage in newborns
Page 1 and 2: Clinical Case JR, JR, 7 do hispanic
Page 3 and 4: Baby Baby was OK at home, eating we
Page 5 and 6: Work Up CBC CBC - WBC 13.6, H/H 18.
Page 7 and 8: ER course VSS, VSS, baby was jaundi
Page 9 and 10: Neonatal Hyperbilirubinemia
Page 11 and 12: Jaundice A A visible manifestation
Page 13 and 14: WHY DO INFANTS DEVELOP HYPERBILIRUB
Page 15: Bilirubin Bilirubin is the breakdow
Page 19 and 20: Blood Blood flow through the hepati
Page 21: Conjugation Bilirubin Bilirubin dis
Page 25 and 26: Neonatal Hyperbilirubinemia Physiol
Page 27 and 28: Disorders of Production Isoimmuniza
Page 29 and 30: Rh Incompatibility This is a blood
Page 31 and 32: ABO Incompatibility This This is a
Page 33 and 34: Erythrocyte Enzymatic Defects Gluco
Page 35 and 36: RBCs RBCs are unable to activate th
Page 37 and 38: Its Its deficiency leads to decreas
Page 39 and 40: Hereditary Elliptocytosis Incidence
Page 41 and 42: Infection Hyperbilirubinemia Hyperb
Page 43 and 44: Polycythemia The The increase in re
Page 45 and 46: Disorders of Conjugation Crigler Cr
Page 47 and 48: Type Type II There There is various
Page 49 and 50: Pyloric Stenosis 10 10-25% 25% of b
Page 51 and 52: Disorders of Enterohepatic Circulat
Page 53 and 54: Breast Milk Jaundice Occurs Occurs
Page 55 and 56: Sequelae Bilirubin Bilirubin may pe
Page 57 and 58: Long Long term sequelae: Kernicteru
Page 59 and 60: Diagnosis and Management There Ther
Page 61 and 62: Risk Assessment Every Every newborn
Page 63 and 64: Assessment of risk - Major Predisc
Page 65 and 66: Carbon Monoxide The The breakdown o
Page 67 and 68:
If: If: When should I do more? Cord
Page 69 and 70:
Algorithm for the management of jau
Page 71 and 72:
Helpful resources Bili-Aid Bili Aid
Page 73 and 74:
Wavelength Wavelength Technique Bil
Page 75 and 76:
Positioning Positioning Within With
Page 77 and 78:
The The TSB level for discontinuing
Page 79 and 80:
Guidelines for exchange transfusion
Page 81 and 82:
Exchange Transfusion With With a ex
Page 83 and 84:
Management Management of Hyperbilir
Page 85 and 86:
Provide parents with written and ve
Page 87:
Fanaroff, Fanaroff, Martin. Neonata
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Neonatal Unconjugated Hyperbilirubinemia

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