Neonatal Unconjugated Hyperbilirubinemia
Neonatal Unconjugated Hyperbilirubinemia
Neonatal Unconjugated Hyperbilirubinemia
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
Conjugation<br />
Bilirubin Bilirubin dissociates from circulating albumin<br />
before its entry into the liver cell<br />
Bilirubin Bilirubin enters the liver by a process of carrier-<br />
mediated diffusion<br />
It It is carried by hepatic ligandin (Y protein) and Z<br />
protein<br />
Bilirubin Bilirubin is presumed to be transported from the<br />
liver cell membrane to the endoplasmic reticulum,<br />
the site of the conjugating enzyme uridine<br />
diphosphate glucuronyl transferase (UDPGT)<br />
After After conjugation, bilirubin is then excreted into<br />
bile in the intestine