IPV BSL-3/polio containment guidelines (Feb 2003) - World Health ...

4.29 The areas for the storage of viral seed stock must be dedicated and fully secured
against entry by non authorised personnel. For secondary (back-up) seed storage
locations where stocks are not normally used for production, the National
Regulatory Authority may approve storage in leak-proof containment containers
within a dedicated freezer with security and access restrictions appropriate for the
storage of poliovirus.
4.30 The viral seed stock must be inventoried. Addition or removal of material must be
conducted by authorized personnel following the approval of two authorized
signatories on record or the electronic equivalent of this approval. Records of
additions or removal of viral seed must be securely stored.
4.31 The viral seed storage area must be equipped with back-up emergency power source
and recording and alarm systems to monitor freezers.
5. DOCUMENTATION AND VALIDATION
5.1 Detailed records of operating parameters for the containment facility should be
produced and maintained for conducting an assessment of the facility performance.
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Adopted by the 53 rd meeting of the WHO Expert Committee on Biological Standardization, 17-21 February 2003. A definitive
version of this document, which will differ from this version in editorial but not scientific detail, will be published in the WHO
Technical Report Series.