Zinc - The Risk Assessment Information System

Dose (mg Zn/kg bw/day)
100000.000
10000.000
1000.000
100.000
10.000
1.000
0.100
70
7373
72 67
70 75
77
72
71737375
6727177727574
70
81
7373
70
70
7373
716674
75
74
66 74
69
70
6667069
70726970
68
72
70
66
69
70
7070
69
6970 7080807580
76
79
70
77575
69
80
80
75
80
75
69
Wildlife TRV Derivation Process Data Evaluation Score
76
74
Figure 6.1 Mammalian TRV Derivation for Zinc
Lowest-Observed Adverse Effect Dose
Paired values from same study when joined by line
No-Observed Adverse Effect Dose
1) There are at least three results available for two test species within the growth, reproduction, and mortality effect groups.
There are enough data to derive a TRV.
2) There are three NOAEL results available within the growth and reproduction effect groups for calculation of a geometric mean.
70 7080
7276
67
74
7276
70 72
80
73
66
75
75 75
73
7676
71
7676
7676
7676 71
68 777375
80
3) The geometric mean is equal to 75.4 mg zinc/kg bw/d and is lower than the lowest bounded LOAEL for results within the reproduction, growth, and survival (MOR) effect groups.
4) The mammalian wildlife TRV for zinc is equal to 75.4 mg zinc/kg bw/day which is the geometric mean of NOAEL results within the reproduction and growth effect groups.
75
77
77 6986747077
77375
77
7079
73 8182
79 86
79 8271
80
82
8282
71
80
74 8282 81
73
78
7872
81
7474
73757974
7282
686978686968
6977 7467687584
75
69
7575
69736974
77
84
69 6868
80 6867
807380 77
83
687368
78
8080
80 83
69
Geometric Mean of NOAELs
for reproduction and growth =
75.4
8171 73
73
71
73
777
76
68
85 83
81 79
7079
84
80
807876
76
7685
76
8480
81
85 80 78
Biochemical (BIO) Behavior (BEH) Physiology (PHY) Pathology (PTH) Reproduction (REP)
Growth (GRO) Mortality (MOR)
BIO-NOAEL BIO-LOAEL BEH-NOAEL BEH-LOAEL PHY-NOAEL PHY-LOAEL PTH-NOAEL PTH-LOAEL REP-NOAEL REP-LOAEL GRO-NOAEL GRO-LOAEL MOR-NOAEL MOR-LOAEL
83
Eco-SSL for Zinc 20 June 2007