Genetic characteristics of field and attenuated rabies viruses ... - Evira

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Finnish Food Safety Authority Evira, Helsinki, Finland Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland Genetic characteristics of field and attenuated rabies viruses and molecular epidemiology of rabies in Finland and Russia Artem Metlin ACADEMIC DISSERTATION To be presented with the permission of the Faculty of Veterinary Medicine, University of Helsinki, for public examination in the Walter Hall, EE-building, Viikki on Monday 28 th of January 2008 at 12 o’clock HELSINKI 2008
Supervised by Anita Huovilainen, PhD, Docent Virology Unit, Department of Animal Diseases and Food Safety, Finnish Food Safety Authority Evira, Helsinki, Finland Olli Vapalahti, MD, PhD, Professor, Haartman Institute, Faculty of Medicine, University of Helsinki, Faculty of Veterinary Medicine, University of Helsinki, Finland Supervising professor Antti Sukura, DVM, PhD, Professor, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, University of Helsinki, Finland Reviewed by Antti Vaheri, MD, PhD, Professor Haartman Institute, University of Helsinki, Finland Thomas Mueller, DVM, PhD, Institute for Epidemiology, WHO Collaborating Centre for Rabies Surveillance and Research, OIE Reference Laboratory for Rabies, Friedrich-Loeffler-Institute – Federal Research Institute for Animal Health, Wusterhausen, Germany Opponent Noel Tordo, DVM, PhD, Pasteur Institute, France
Page 1: Evira Research Reports 2/2008 Artem
Page 5 and 6: 3.5. Laboratory techniques.........
Page 7 and 8: Abstract Rabies is a fatal disease
Page 9 and 10: List of original publications I. Me
Page 11 and 12: 1.2.2. Structure of virion, genome,
Page 13 and 14: al., 1989; Benmansour et al., 1991)
Page 15 and 16: Prodromal period - the first 1 to 3
Page 17 and 18: A. C. Figure 4. A&B. Perivascular c
Page 19 and 20: the skin biopsies (Bryceson et al.,
Page 21 and 22: cells, murine monocytic P388D1 and
Page 23 and 24: 1.5.2. Rabies situation in Europe a
Page 25 and 26: It is well established that the mai
Page 27 and 28: widely used oral anti-rabies vaccin
Page 29 and 30: have to be surpassed. Since then, s
Page 31 and 32: There are two ways of distributing
Page 33 and 34: The RT-PCR amplification, nucleotid
Page 35 and 36: into the M13 vectors. Conzelmann et
Page 37 and 38: 3. Materials and methods 3.1. Field
Page 39 and 40: was added to all mixtures and these
Page 41 and 42: The total RNA was purified from the
Page 43 and 44: 4. Results 4.1. FAT and cell cultur
Page 45 and 46: 4.4. Phylogenetic analysis and mole
Page 47 and 48: group differ from those observed in
Page 49 and 50: The vaccine strains RV-97 and SAD B
Page 51 and 52: 5. Discussion Rabies is a serious v
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as from non-infectious diseases (e.
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Nevertheless, the major rivers rema
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antigenic sites (epitopes) of the G
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The data included in this thesis ca
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7. Заключение (concluding
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8. Acknowledgments The work for thi
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19. Beauregard, M., Boulanger, P.,
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46. Brozka, K., Finke, S., Conzelma
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75. Dietzschold, B., Lafon, M., Wan
Page 71 and 72:
107. Hellenbrand, W., Meyer, C., Ra
Page 73 and 74:
141. Kumar, S., Tamura, K., Nei, M.
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169. McElhinney, L.M., Marston, D.,
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197. Niin, E., Laine, M., Partel, A
Page 79 and 80:
230. Selimov, M.A., Botvinkin, A.D.
Page 81 and 82:
262. Tollis, M., Buonavoglia, C., T
Page 83 and 84:
295. Wunner, W.H., 1991. The chemic
Page 85 and 86:
J. Vet. Med. B 51, 94-96 (2004) Ó
Page 87 and 88:
96 A. E. Metlin et al. Mu¨ ller, T
Page 89 and 90:
125•Mise globale 23.2.2006 9:58 P
Page 91 and 92:
125•Mise globale 23.2.2006 9:58 P
Page 93 and 94:
125•Mise globale 23.2.2006 9:58 P
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CASE REPORT REFEREED Imported Case
Page 97 and 98:
Figure 1. Neighbor-joining phylogen
Page 99 and 100:
Paper IV
Page 101 and 102:
study. The reverse transcription-po
Page 103 and 104:
Table 1 (continued) Code Origin Ani
Page 105 and 106:
Fig. 2. Geographical distribution o
Page 107 and 108:
Besides rivers, mountain ranges wer
Page 109:
Paper V
Page 112 and 113:
104 105 106 107 108 109 110 111 112
Page 114 and 115:
154 155 156 157 158 159 Q5 160 161
Page 116:
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