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ICSTI Statement on Nanotechnology - Forfás

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64<br />

Elan Corporati<strong>on</strong> develops and markets pharmaceuticals and<br />

drug-delivery technology. Its pharmaceutical business focuses <strong>on</strong><br />

neurology, pain management, dermatology, antibiotics, and<br />

autoimmune diseases. Its drug delivery business developed and<br />

patented the NanoCrystal system for formulating poorly soluble<br />

compounds as nanoparticles, thereby increasing their surface area<br />

and their solubility. There are currently two pharmaceutical<br />

products that have been commercialised incorporating<br />

NanoCrystal technology, with several additi<strong>on</strong>al product launches<br />

anticipated over the next two years. The NanoCrystal technology<br />

is protected by 85 issued US patents and 48 pending patents.<br />

Elan has established manufacturing scale capability for<br />

pharmaceutical products formulated using their proprietary<br />

NanoCrystal technology at their Irish development and<br />

manufacturing site in Athl<strong>on</strong>e. A drug in nano-form can be<br />

incorporated into comm<strong>on</strong> dosage forms, including tablets,<br />

capsules, inhalati<strong>on</strong> devices, sterile forms for injecti<strong>on</strong>, with the<br />

potential for substantial improvements to clinical performance.<br />

Aerogen Ireland Ltd is a subsidiary of Aerogen Inc based in<br />

California, a specialty pharmaceutical company developing inhaled<br />

drug products to advance the treatment of respiratory disorders<br />

and chr<strong>on</strong>ic diseases. The company is focused <strong>on</strong> efficient,<br />

c<strong>on</strong>venient delivery of aerosolised drugs to the lungs, and<br />

through the lungs to the blood stream. Its Irish operati<strong>on</strong>s are<br />

based in Galway where the core business is in the manufacture of<br />

pulm<strong>on</strong>ary drug delivery devices. Aerogen’s range of current and<br />

future products includes specialised nebulisers and breathactivated<br />

inhalers for marketing by Aerogen, as well as novel<br />

inhalers for leading pharmaceutical and biotechnology companies.<br />

Aerogen have recently established a small three-pers<strong>on</strong> team,<br />

based in Galway, to formulate drugs as nanoparticles for aerosol<br />

delivery. The company has stated that the recent changes to Elan<br />

in this country have led to the availability of some highly skilled<br />

individuals.

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