BIOCH€MtSTRY

A|MS OF TEE WORX
A er.e Eldionship b.ts@ lipid i.lrtc ir diel md sn chol€saol |d r in
Erious populaion *udi.s Bing dind .xpqin6i! dmdout rh. mrld ha b6
d.mo.sra.d to br th. l*ding oe of ishdic had di5as (trD). h4qfiion
studi* (by cnosins lipid @npolitim ofdid) dis?hy€d tt clin d IHD 616 &d chds€ in
ftan som choLsi@l l@1. Th€ blod cholerhl leEl sraliarns vlry fron @nEy to
ouiEy Upid prcfilc @l.dort in diffcrdr IHD srdi.c dmnlr t !i8 f@t
rcl.tio.ship b.twd IHD nonrlity rales sid @n cholddol onccnftrion on tn€ onc
hhd ad bc.l@ tot3l dddftl ondnidion dd low fiDL.l'ole{@l @n6taion
ontheothd On. @ nor yet pd.eive a rhrdhold ldll ofcnobsl€rol @rc.nlrdion .bov.
Nltidr tlte rtuk of EiD irc:qs. The blood crDl6t@l l@eh of lh. dift rqt DotrLtioB
ec .lso dispulabl€ undd the diferdl @iddiology of life styl. ud gpogEphiml
@ndition ofa @ ry dd food hrbiri bdDviN of ft. p@pl. nt6nriioid and
inrr.,utiond, @ry sutrciar wig)ri ro @h a onm6.
Th. Fmirsh.n Hdl Study and oth6 .gidediologic srdid sho*.d gtand
incidde of IHD @ona vdjd! sudy gNps of poFiarid sl'o a. cigd€tc sok6,
sutr riig from hrT.ndsio4 lddr blood SJuo*, obeity, ECG .bionnaliry, lrk of
qcrcie dd sBs indi€t d irdivitu l ar lish rtt .m std Oc oE all lipid pofile
(i.e. tu chole$erol. Triely.did€, rlDl{hol€ddol LDLcholdt€oD falh on bo'dq
In fih @ndr of *udv. on€ should thi.k oor. us.tul 10 look dl !h.
?idmiolosic.! pdda6 a dahid of rh.lHD tut f.dm dd dE bi@n@icil
rut6 lik.. toral Flm cholGtqol. LDL, tlDl. VLDI" .polippretei. A-1,
, apolipprct in-B, lipoprolcin p.nicle 3i2., oxidiz.d LDL .!d HDL $lE!.riotu and
uiSlyqid. rich lipoprci.in pa.ti.l6, rhd s dhae rhe pEdiclability ofIHD in Ptti€tn3
of rh. Dd sio@rcnic ondirioB of rlF ud€i dcvclo!€d @urfri4 like Palisl!..
It ws tha.fq. rcmpting to !tudy the did!ry h.bit! ofth. inn$irrnb of lr.kat!
divkion in gerdal, who rcside in urbm dd rual e&r naviDg difrsdl ecitl 8nd etnhic