Coagulation Factors in Controlling Traumatic Bleeds: FFP, PCC, or ...
Coagulation Factors in Controlling Traumatic Bleeds: FFP, PCC, or ...
Coagulation Factors in Controlling Traumatic Bleeds: FFP, PCC, or ...
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APPENDICES (cont<strong>in</strong>ued)<br />
APPENDIX D 49,50<br />
Comparison of <strong>PCC</strong> Products (available <strong>in</strong> the US)<br />
Characteristic Profiln<strong>in</strong>e ® SD Bebul<strong>in</strong> ® VH<br />
Source material<br />
Pooled human plasma<br />
Microbial<br />
Solvent detergent<br />
Vap<strong>or</strong> heated<br />
reduction<br />
F<strong>or</strong>mulation Lyophilized concentrate <strong>in</strong> s<strong>in</strong>gle-dose vials Lyophilized concentrate <strong>in</strong> s<strong>in</strong>gle dose vials<br />
with ~0.15 units hepar<strong>in</strong> per unit fact<strong>or</strong> IX<br />
Fact<strong>or</strong><br />
composition<br />
Approved<br />
<strong>in</strong>dication<br />
St<strong>or</strong>age/shelf-life<br />
Adverse effects<br />
Potency per 1 unit fact<strong>or</strong> IX<br />
100-150 units/mL fact<strong>or</strong> IX<br />
≤ 1.5 units fact<strong>or</strong> II<br />
≤ 1 unit fact<strong>or</strong> X<br />
≤ 0.35 units fact<strong>or</strong> VII<br />
Refrigeration at 2-8 °C until expiration date<br />
Room temperature (≤30 °C) up to 3 months<br />
After reconstitution, use with<strong>in</strong> 3 hrs<br />
Thrombosis<br />
Infectious disease transmission<br />
Infusion reactions<br />
Potency per 1 unit fact<strong>or</strong> IX<br />
24-37.5 units/mL fact<strong>or</strong> IX<br />
~1 unit/mL fact<strong>or</strong> II<br />
~1 unit/mL fact<strong>or</strong> X<br />
≤ 0.20 units fact<strong>or</strong> VII<br />
Fact<strong>or</strong> IX deficiency due to hemophilia B<br />
Refrigeration at 2-8 °C until expiration date<br />
Room temperature stability not available<br />
After reconstitution, use with<strong>in</strong> 3 hrs<br />
Thrombosis<br />
Infectious disease transmission<br />
Infusion reactions<br />
Hepar<strong>in</strong>-<strong>in</strong>duced thrombocytopenia<br />
APPENDIX E 52<br />
Marshall CT Classification<br />
Categ<strong>or</strong>y<br />
Diffuse <strong>in</strong>jury I<br />
(no visible pathology)<br />
Diffuse <strong>in</strong>jury II<br />
Diffuse <strong>in</strong>jury III<br />
Diffuse <strong>in</strong>jury IV<br />
Evacuated mass lesion<br />
Non-evacuated mass<br />
lesion<br />
Def<strong>in</strong>ition<br />
No visible <strong>in</strong>tra-cranial pathology on CT scan (9.6% m<strong>or</strong>tality)<br />
Cisterns present with midl<strong>in</strong>e shift 0-5 mm and/<strong>or</strong> lesion densities present; no high <strong>or</strong><br />
mixed density lesion > 25 mL (13.5% m<strong>or</strong>tality)<br />
Cisterns compressed <strong>or</strong> absent with midl<strong>in</strong>e shift 0-5 mm; no high- <strong>or</strong> mixed-density<br />
lesion > 25 mL (34% m<strong>or</strong>tality)<br />
Midl<strong>in</strong>e shift > 5 mm; no high- <strong>or</strong> mixed-density lesion > 25 mL (56.2% m<strong>or</strong>tality)<br />
Any lesion surgically evacuated<br />
High <strong>or</strong> mixed density lesion > 25 mL; not surgically evacuated<br />
APPENDIX F 51<br />
Glasgow Coma Scale & Sc<strong>or</strong>e<br />
Feature Scale Response Sc<strong>or</strong>e Notation<br />
Eye open<strong>in</strong>g<br />
Spontaneous<br />
To voice command<br />
To pa<strong>in</strong> stimuli<br />
No response<br />
4<br />
3<br />
2<br />
1<br />
Verbal response<br />
Best mot<strong>or</strong> response<br />
Oriented and converses<br />
Confused<br />
W<strong>or</strong>ds (<strong>in</strong>appropriate)<br />
Sounds (<strong>in</strong>comprehensible)<br />
No sounds<br />
Obeys commands<br />
Localizes to pa<strong>in</strong><br />
Withdrawals from pa<strong>in</strong><br />
Dec<strong>or</strong>ticate postur<strong>in</strong>g<br />
Decerebrate postur<strong>in</strong>g<br />
None<br />
Total Coma Sc<strong>or</strong>e 3/15 – 15/15<br />
5<br />
4<br />
3<br />
2<br />
1<br />
6<br />
5<br />
4<br />
3<br />
2<br />
1<br />
R. Sohraby 19
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