CANCER CHEMOTHERAPY ACENAPHTHENE ... - Cancer Research

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Downloaded from cancerres.aacrjournals.org on August 30, 2013. © 1956 American Association for Cancer Research. 27 CARBAMATE, ETHYL â€”¿METABOLISM (INCLUDING EFFECTS ON METABOLIC PROCESSES) (Continued) 402 Skipper, H. E., Bennett, L. L., Jr., Bryan, C. E., White, L., Jr., Newton, M. A. and Simpson, L. CARBAHATESIN THE CHEMOTHERAPY OF LEUKEMIA. VIII. OVER-ALL TRACER STUDIES ON CARBONYL-LABELEDURETHAN, METHYLENE-LABELED URETHAN, AND METHYLENE-LABELEDETHYL ALCOHOL. Cancer Res., 1951, 11: 46-51. 6 refs. Abstracted in: Chem. Abstr., 1951, 45: 8655d See 816 2213 822 2394 1463 2718 MODE OF ACTION 1828 2208 403 Beickert, A. and Jorke. D. EXPERIMENTELLE UNTER SUCHUNGEN ZUM WIRKUNGSMECHANISMUS DES URETHANS. [EXPERIMENTAL STUDY OF THE MECHANISM OF ACTION OF URETHANE.] 954, 960. 47 Zschr. ges. inn. Hed., 1952, 7: refs. Abstracted in: Excerpta" med., Sect. 16, 1954, No. 562; Chem. Abstr., 1953, 47: No. 10699d. 404 Beickert. A. ÃœBER DIE AFFINITÃ„T DES URETHANS ZU VERSCHIEDENEN ZELLFORMEN DES NORMALEN UND LEUKÃ„MISCHEN BLUTES. [AFFINITY OF URE THANE FOR SEVERAL TYPES OF CELLS IN NORMAL AND LEUKEMIC Beri., 1950, BLOOD.] Arch. 210: 473-478. exp. Path. 12 refs. ' 405 BÃ¼cher,,O. ZUR WIRKUNG VON URETHAN AUF GEWEBE KULTUREN IN VITRO. [ON THE INFLUENCE OF URE THANE ON TISSUE CULTURES IN VITRO.] Schweiz, ned. Wschr., 1947, 77: 1229-1230. Abstracted in: Excerpta med., Sect. 5, 1948, Ij No. 722. 406 Feher. L. VIZSGÃ‚LATOK AZ URETHAN HATÃ„SMECHANIZ- MUSAROL KRONIKUS MYELOID LEUKAEMIÃ‚BAN. fIN VESTIGATIONS INTO THE MECHANISM OF ACTION OF URETHANE IN MYELOID LEUKEMIA.] 1948, 89: No. 10-11, 175-176. Orv. hetilap, 6 refs. Abstracted in: Excerpta med., 2: No. 4755. "The metabolism Sect. 2, 1949, of uric acid Â¡Turingadministration of urethane in five leukemic confined patients was to the white investigated...effect cells...Uric acid excretion is not proportional to the decrease of the white cells..." -Excerpta med. 407 Fochem, K., Reimer, E. and Schmid, J. EINFLUSS DER RONTGENSTRAHLEN AUF DIE URETHANWIRKUNG. [EFFECT OF ROENTGEN RAYS ON THE ACTION OF URETHANE]. Wien. Zschr. inn. Med., 1951, 32- 31-36. 22 refs. 408 Green, J. w. Jr. and Lushbaugh, C. C. HISTO- PATHOLOGIC STUDY OF THE MODE OF INHIBITION OF CELLULAR PROLIFERATION BY URETHANE: EF FECT OF URETHANE ON WALKER RAT CARCINOMA 256. Cancer Res., 1949, 9: 199-209. 28 refs. Abstracted in: BioT. Abstr., Bait., 1951, 25: No. 13773. Urethane was shown to inhlTjit cellular proliferation in part by nutritional debilitation of the animal. The drug does not arrest mitosis but causes an increase in the number of probably fatal abnormal mitoses in the malignant cells. 409 Kelemen, E. L'URETHANE. LE MÃ‰CANISME D'ACTION DES NOUVEAUX DÃ‰RIVÃ‰SCARBAMIDÃ‰S EMPLOYES EN THERAPEUTIQUE. [URETHANE. THE MECHANISM OF ACTION OF THE NEW CARBAMIDE DERIVATIVES USED THERAPEUTICALLY.] Sang, Par., 1948, 19: 50- 56. 35 refs. Abstracted in: Excerpta med.. Sect. 5, 1949, 2: No. 1473. 410 Lande, A. UEBER DEN HISTOCHEMISCHEN NACHWEIS VON KEHNVSRÃ„NDERUNGENAN BLUTZELLEN DURCH URETHAN UND SEINEN WIRKUNGSMECHANISMUS BEI BEHANDLUNG MYELO-LYMPHATISCHER ERKRANKUNGEN. [HISTOCHEMICAL DEMONSTRATION OF NUCLEAR CHANGES CAUSED BY URETHANE AND ITS MODE OF ACTION IN THE TREATMENT OF MYELO-LYMPHATIC DISEASES.] 38 1. MÃ¼nchen, 1951. (Inaug.- Diss., MUnchen) 14 refs. 411 Lelbetseder, F. and Kwerch, H. UBETHANWIHKUNG UND VEGETATIVES NERVENSYSTEM. [ACTION Of URETHANE AND THE AUTONOMIC NERVOUS SYSTEM.] Zschr. klin. Med., 1951, 148: 180-190. 35 refs. 1952, Abstracted in: Excerpta med.t Sect. 5: No. 2275. "A study on the action 2, of ureÃ‡han on the blood and the haemopoietic organs in cats showed that this drug may pro duce agranulocytosis and aplasia of the bone marrow and lymphatic tissue. When di hydroergotamine or atropine was given simultaneous ly the appearance of agranulocytosis was mark edly accelerated. When it was combined with atropine, the lymph nodes and spleen showed a reticulosis with epithelioid-like cells and giant cells. It is concluded that urethan does not only act directly on the cell, but also via the central and the autonomie nervous systems on the regulation haemopoiesis." - Excerpta med. of the 412 Lennert, K. ÃœBER MORPHOLOGIE UND MECHANISMUS DER URETHANWIRKUNG. [MORPHOLOGY AND MECHANISM OF URETHANE.] Klin. Wschr., 1948, 26: 735- 736. 413 r.AÂ». GEN MIT URETHAN. EXPERIMENTELLE [NEW EXPERIMENTAL ERFAHRUN STUDIES ON EFFECTS OF URETHANE]. Fol. haemat., Lpz , 1951, 70: 78-81. 414 Heythaler, F. MECHANISMUS and Handel, F. WIRKUNG UND DES â€¢¿ATHYLURETHANS.[EFFECTS WIRKUNGS AND MECHANISM OF ACTION OF ETHYL URETHANE.] Verh. Deut. Ges. inn. Med., 1949, 55: 406-408. 415 Moeschlin, S. KLINISCHE UND EXPERIMENTELLE UNTERSUCHUNGEN ÃœBER DEN WIRKUNGSMECHANISMUS DES URETHANS. [CLINICAL AND EXPERIMENTAL INVESTIGATIONS OF THE MECHANISM OF ACTION OF 1: URETHANE.] Acta haemat., Basel, 1948, 225-247. Bibliography: p. 246-247. Abstracted in: Chem. Abstr., 1949, 43: 9263d. 416 Â«oeschlin, S. RECHERCHES CLINIQUES ET EXPÃ‰RI MENTALES SUR LE MECANISME D'ACTION DE LtURÃŽ- THANE. [CLINICAL AND EXPERIMENTAL INVESTI GATIONS ON THE MECHANISM OF ACTION OF URE THANE.] Sang, Par., 1948, lj): 543-549. 6 refs. Abstracted 44: 7561. "Urethan in: Chem. Abstr., 1950, acts directly or indirect ly on the cellular proliferation by inhibi ting mitosis. The inhibition seems to bear on the enzyme system required for multipli cation. Urethan the synthesis of probably does not nucleoprotelns." affect -Chem. Abstr. 417 Moeschlin, S. WIRKUNGSMECHANISMUS DES URETHANS BEI LEUKÃ„MIEN. [MODE OF ACTION OF URETHANE IN 195-196. LEUKAEMIA.] 2 refs. Experientia, Abstracted Basel, in: Excerpta" 1947, 3: med., Sect. 2, 1948, Â¿: No. 3242. 418 Moeschlin, S. ZUM WIRKUNGSMECHANISMUS DES URE THANS BEI LEUKÃ„MIEN. [THE MODE OF ACTION OF URETHANE IN LEUKAEMIA.] Helvet. med. acta, 1947, 14: 279-294. 10 refs. Abstracted in: Excerpta med., Sect. 5, 1948, 1_:No. 408.
Downloaded from cancerres.aacrjournals.org on August 30, 2013. © 1956 American Association for Cancer Research. 28 CARBAMATE, (Continued) ETHYL â€”¿MODE OF ACTION 419 Schmid, J. BEITRAG ZDH WIRKUNGSMECHANISMUS DES URETHAN. [STUDY ON THE MECHANISM OF ACTION OF UHETHANE.] Wien. Zschr. inn. Med., 1948, 29: 389-397. 16 refs. , 420 Schmid, W. and Kunz, W. WIRKUNGSUNTERSCHIEDE ZWISCHEN URETHANEN UND ANDEREN NARKOTICIS AM ZELLSTOFFWECHSEL VON HEFE UND ASCITESTUMOR. [DIFFERENCES IN MODE OF ACTION OF URETHANE AND OTHER NARCOTICS ON CELL METABOLISM OF YEAST AND ASCITES TUMOR.] Arch. exp. Path., Beri., 1953, 218: 100. 421 Schulze, E. URETHAN, THERAPEUTISCHE VERWENDUNG UND MECHANISMUS SEINER WIRKUNG. [URETHANE, THERAPEUTIC USE AND MECHANISM OF ACTION.] Pharmazie, Beri., 1949, 4: 118-122. See 23 133 323 425 454 498PHARMACOLOGICAL 1030 AND PHYSIOLOGICAL EFFECTS 422 Cruz, W. 0. and Moussatche, H. ACUTE THROMBO- CYTOPENIA INDUCED IN DOGS BY ADMINISTRATION OF URETHANE (ETHYL-CARBAMATE) . Blood, Bait., 1948, 3: 793-798. 11 refs. Abstracted in: Excerpta med., Sect. 2, 1949, 2: No. 992. 423 Cruz, W. 0. and Silva, E. M. da. CONTRIBUTION ON THE THROMBOCYTOPENIC ACTION OF URETHANE IN DOGS. Brit. J. Pharm., 1949, 4: 132-134. 9 refs. 424 Heilmeyer, L. KLINIK UND PHARMAKOLOGIE DES URETHANS UND ANDERER CYTOSTATISCHER STOFFE. [CLINICAL AND PHARMACOLOGICAL STUDIES OF UHETHANE AND OTHER CYTOSTATIC DRUGS.] 120 p. Stuttgart, Wissenschaftliche Verlagsgesell schaft, 1948. (Beihefte zur Medizinischen Monatsschrift. Heft. 4). 268 refs. 425Hirscher, H. and Billerbeck, K. 'ÃœBERPATHOL.- ANATOMISCHE BEOBACHTUNGEN UND PHAGOZYTOSE- ERSCHEINUNGEN AN URETHAN BEHANDELTEM MULTI PLEM MYELOM. [MORBID ANATOMY AND PHAGOCY TOSIS IN MULTIPLE MYELOMA TREATED WITH URETHANE.] Aerztl. Wschr., 1950, 5: 239- 243. 28 refs. Abstracted in: Excerpta ned., Sect. 5, 1951, 4: No. 2192. "The changes indicate that urethan causes dis turbances in the fermentation mechanism of the cells, especially in the so-called yellow oxidation ferments system. Findings in the bone marrow, e.g. phagocytosis in the plasmocytoma cells, indicate that tu mour cells possibly originate from the large lymphoid reticulum cells of the bone marrow." -Excerpta med. 436 Hirscher, H. and Laur, 0. MORPHOLOGISCHE VERÃ„NDERUNGEN AN PLASMOZYTOMZELLEN UNTER URETHANWIRKUNG, ZUGLEICH EIN BEITRAG ZUR FRAGE DER PARAPROTEINE. [MORPHOLOGICAL CHANGES OF THE MYELOMA CELLS DUE TO THE ACTION OF URETHANE. A CONTRIBUTION TO THE QUESTION OF PARAPROTEINS.] Zschr. ges. inn. Med., 1950, 5: 641-645. 47 refs. Abstracted in: Excerpta med., Sect. 5, 1951, 4: No. 2521. 427 Klima, R. and Wengraf, G. ÃœBER DIE EINWIRKUNG VON URETHAN UND ANDEREN SCHLAFMITTELN AUF DIE ZENTRAL NERVÃ–SE BLUTSTEUERUNG BEI BLUT KRANKHEITEN. [THE EFFECT OF URETHANE AND OTHER SOPORIFICS ON THE REGULATION OF THE BLOOD BY THE CENTRAL NERVOUS SYSTEM IN DISEASES OF THE BLOOD.] Wien, 1949. 99: 503-505. Abstracted med. Wsohr., in: Excerpta med., Sect. 5, 1950, 3: No. 3386. 428 Lennert, K. DIE MORPHOLOGIE DER URETHANWIRKUNG BEI LEUKÃ„MIEN, MALIGNEN TUMOREN DES LYMPHA TISCHEN SYSTEMS UND DER LYMPHOGRANULOMATOSE. [MORPHOLOGICAL EFFECTS OF URETHANE IN LEUKE MIA, MALIGNANT NEOPLASMS OF THE SYSTEM AND HODGKIN'S DISEASE.] LYMPHATIC Frankf. Zschr. Path., 1950, 61: 339-370. 43 refs. Abstract ed in: ExcerptiT med., Sect. 5, 1951, 4: No. 495. 429 Linke, A. and Ulmer, W. ÃœBER DEN EINFLUSS DER BEHANDLUNG MIT XTHYLURETHAN AUF DIE PHAGCCYTOSEFAHIGKEIT UND STICKSTOFFLOST MENSCHLICHER LEU- KOCYTEN. [EFFECT OF TREATMENT WITH ETHYL URE THANE AND NITROGEN MUSTARD ON THE PHAGOCYTIC ACTIVITY OF HUMAN LEUCOCYTES.] Klin Wschr., 1952, 30: 273-277. 20 refs. Leucocytes from pÃ¤Tients under treatment with urethane and/or nitrogen mustard do not show a decrease in their phagocytic activity. 430 Linke, A. and Ulmer, W. DIE WIRKUNG VON XTHYL URETHAN AUF DIE PHAGOCYTOSEFÃ„HIGKEIT MENSCHLI CHER LEUKOCYTEN IN VITRO. [EFFECT OF ETHYL URETHANE ON THE PHAGOCYTIC ACTION OF HUMAN LEUCOCYTES IN VITRO.] Klin. Wschr., 1951, 29: 471-473. 17 refs. Ethylurethane inhibTts phagocytosis but does not disturb the process in therapeutic quantities. 431 Masshoff, W., Heinzel, W., Rom, G. D. von and Siess, M. EXPERIMENTELLE UNTERSUCHUNGEN ÃœBER DIE WIRKUNG VON URETHAN AUF PHAGOCYTOSE, SPEI CHERUNG UND ENTZÃœNDUNG. [EXPERIMENTAL STUDIES ON THE EFFECT OF URETHANE ON PHAGOCYTOSIS, STORAGE, AND INFLAMMATION.] Klin. Wschr., 1948, 26: 397-400. 13 refs. 432 Osgood, E. E. and Chu, I. T. THE EFFECT OF URETHANE ON THE NUCLEAR MORPHOLOGY OF CELLS OF THE GRANULOCYTE SERIES AS OBSERVED IN MARROW CULTURES AND LEUKEMIC BLOOD. Blood, Bait., 1948, 3: 911-917. 17 refs. Also in: Sympos. HematT, N. Y., 1949, 598-604. 43fandkUhler, S. DAS VERHALTEN DER BLUTPHAGOCYTEN UNTER CHEMOTHERAPEUTISCHEN KUREN. [THE BE HAVIOR OF THE BLOOD PHAGOCYTES DURING CHEMO THERAPY.] Sang, Par., 1950, 21: 400-404. See: 386 3199 SYNERGISTIC ACTION 434 'Zushbaugh, C. C. and Storer, J. B. SYNERGISTIC NECROTIZING ACTION OF URETHANE AND CHLOROFORM. Arch. Path., Chic., 1948, 45: 494-502. 11 refs. Urethane and chloroform are additively synereistic and when given together even in sublethal amounts may cause fatal hepatic injury. Three case histories and experimental work with rabbits in which the two compounds were used as treat ment are reported.
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