CANCER CHEMOTHERAPY ACENAPHTHENE ... - Cancer Research

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39
CARBAMATE, ETHYL —¿TOXICITY, COUNTERACTION
TO
642 Riegel, R. URETHAN UND HYALURONIDASE. DIE
VERWENDUNGVON HYALURONIDASE BEI DER INTRA
MUSKULÄRENAPPLIKATION VON URETHAN. VOR
LÄUFIGE MITTEILUNG. [USE OF HYALURONIDASE
IN INTRAMUSCULAR ADMINISTRATION OF URETHAN.
PRELIMINARY COMMUNICATION.] Deut. med.
«sehr.,
Excerpta
1953, 78:
med.,~Sect.
885-886. Abstracted
2, 1954, 7: No.
in:
2734.
CARBAKATE,
PHENYL-
643
Crick, J. and Jackson, H. A TRACER STUDY OF
THE METABOLISM OF P-IODOPHENYL URETHANE; THE
SELECTIVE LOCALIZATION OF RADIOACTIVE MATERIAL.
Brit. J. Pharmacol., 1952, 7: 142-151. 10 refs.
644
Fornara, P. LEUCEMIE INFANTILI TRATTATE CON
FENILURETANO. [PHENYL CARBAMATE TREATMENT OF
LEUKEMIA IN CHILDREN.] Minerva med., Tor.,
1949, 40: pt. 2, 293-294.
645
Pekhtereva, S. I. VLIIANIE FENILURETANA NA
ROST RAKA ERLIKHA U MYSHEI. [EFFECT OF
PHENYLURETHANE ON GROWTH OF EHRLICH CARCI
NOMA IN MICE.] Biull. eksp. biol. med.,
1954, 37: No. 2, 65-67. 1 reí. Daily
subcutaneous injections of 10 mg phenylurethane
caused inhibition of Ehrlich carci
nomas in 86 mice. Tumor growth regression
was observed only during drug administra
tion. Phenylurethane given with arginine
markedly reduced the cancerogenic effects
of the latter.
646
Sentein, P. LA RESTAURATION DE L'APPAREIL
ACHROMATIQUE APRES SA DÉPOLARISATION PAR
LES SUBSTANCES ANTIMITOTIQUES. [RESTITU
TION OF THE ACHROMATIN COMPLEX AFTER ITS
DEPOLARIZATION BY ANTIMITOTIC COMPOUNDS.]
C. rend. Ass. anat., 1950, 37: 462-470.
9 refs. Detailed description of the mode
of action of phenylurethane on the cells
of the egg of Triturus helveticus Raz,
during segmentation.
See:
1288
CARBAMATE,
2-THIO-
647 Powell, A. K. EFFECT OF DITHIOCARBAMATES ON
SARCOMA CELLS AND FIBROCYTES CULTURED IN
VITRO. Brit. J. Cancer, 1954, 8: 529-534.
2 pi. 13 refs. 'The toxicities of piperidinium
pentamethylene-, sodium pentamethylene-,
and sodium diethyldithiocarbamates to sarcoma
cells and embryonic mouse fibrocytes cultured
in vitro have been studied. Sodium diethyldithiocarbamate
is the least toxic of these
compounds and is more toxic to sarcoma cells
than fibrocytes in rapidly growing cultures.
It is suggested that this property may be
related to the reported effects of this com
pound on oxidation-reduction systems and
cellular respiration."
CARBAMATES
648
Skipper, H. E. and Bryan, C. E. CARBAMATES IN
THE CHEMOTHERAPY OF LEUKEMIA. III. THE RE
LATIONSHIP BETWEEN CHEMICAL STRUCTURE AND
ANTI-LEUKEMIC ACTION OF A SERIES OF URETHAN
DERIVATIVES. J. Nat. Cancer Inst., 1949, 9:
391-397. 25 refs. Abstracted in: Chem. AEstr
1949, 43: 6737a.
649
Vartiainen, L. and Vartiainen, o. URETHAN
DERIVATIVES IN LEUKEMIA. Ann. med. int.
fenn., 1950, 39: 205-210. tab. réf.
650
Winchester, W. W. THE EFFECT OF URETHANE AND
SEVERAL URETHANE DERIVATIVES ON TRANSPLANTED
MYELOGENOUS LEUKEMIA IN THE MOUSE. 217 t.
16 pl. Minnesota, 1952, Thesis-Univer. Minn.
(Typewritten). 189 refs. A report on leuke
mia and 3 of its derivatives, 2,4-oxazolidinedione(Misc.-20),
isopropyl carbamate(D-93)
and ethyl N-methylcarbamate(D-94). "All were
inferior to urethane in prolonging the lives
of animals with myelogenous leukemia, or in
producing hématologie remissions of their
disease. Though apparently not as hepatotoxic
as other drugs tested, urethane exhibi
ted a specific toxic effect on the capillaries
as evidenced by pulmonary edema. This com
plication of its administration proved to be
the limiting factor in accomplishing satis
factory treatment. It was not possible to
discover a satisfactory dosage or method of
administration that was adequate to control
the leukemic process without producing pul
monary edema."
See
1288
CARYOMYCIN
651
Okami, Y., Okuda, T., Takeuchi, T., Nitta, K.
and Umezawa, H. STUDIES ON ANTI-TUMOR SUB
STANCES PRODUCED BY MICROORGANISMS. IV.
SARKOMYCIN-PRODUCING STREPTOMYCES AND TWO
OTHER STREPTOMYCES PRODUCING THE ANTI-TUMOR
SUBSTANCE NO. 289 AND CARYOMYCIN. J. Anti
biotics, Ser. A, Tokyo, 1954, 7: 1953, 6:
153-157.
CARZINOPH1LIN
652
Hâta, T., Koga, F., Sano, Y., Kanamori, K.,
Matsumae, A., Sugawara, R., Hoshi, T.,
Shima, T., Ito, S. and Tomizawa, S.
CARZINOPHILIN, A NEW TUMOR INHIBITORY SUB
STANCE PRODUCED BY STREPTOMYCES. I.
J. Antibiotics, Ser. A, Tokyo, 1954, 7:
107-112. 5 refs. In English. Carzinophilin
showed antibacterial activity against gram
positive bacteria particularly S. lutea, and
brought about destruction of tumor cells and
prolongations of life in animals inoculated
with Yoshida sarcoma, Ehrlich carcinoma and
ascetic hepatoma of 7974 strain.
653 Koga, F. EXPERIMENTALTREATMENTOF MALIG
NANTTUMORWITH ANTIBIOTICS. II. EXPER
IMENTALTREATMENTWITH A NE* ANTIBIOTIC,
CARZINOPHILIN. J. Antibiotics, Ser. A,
1954, 7:176-177.
CARZODELAN
see ENZYMES,
CATHARTICS
PROTEOLYTIC
654 Belkin, M. and Fitzgerald, D. B. TUMOR-DAMAGING
CAPACITY OF PLANT MATERIALS. I. PLANTS USED
AS CATHARTICS. J. Nat. Cancer Inst., 1952,
13: 139-155. 3 pi. 13 refs.
CB1348
see NITROGEN MUSTARDS. BUTYRIC ACID, N, N-DI-2-
CHLOROETHYL-p-AMCNOPHENYL-