CANCER CHEMOTHERAPY ACENAPHTHENE ... - Cancer Research

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Downloaded from cancerres.aacrjournals.org on August 30, 2013. © 1956 American Association for Cancer Research. CARBAMATE, (Continued) ETHYL â€”¿ SYNERGISTIC ACTION 435 Skipper, H. E. CARBAMATES IN THE CHEMOTHERAPY OF LEUKEMIA. V. OBSERVATION OF A POSSIBLE ANTILEUKEMIC SYNERGISM BETWEEN URETHANE AND METHYL-BIS (? -CHLOROETHYL)AMINE. Cancer, N. Y., 1949, 2: 475-479. 24 rets. See: 3056 THERAPY 436 Aas. K. MYELOMATOSIS WITH NORMAL SERUM-PROTEIN VALUES, TREATED WITH URETHAN. Acta med. scand., 1949, 135: 426-438. 35 refs. Abstract ed in: Chem. AEsTr., 1950, 4Â£: No. 3129Ã•. 437 Ajamil, L. F. and Fuentes-Ferrer . J. J. URETANO Y CANCER PROSTATICO. [URETHANE AND CANCER OF THE PROSTATE]. Bol. Liga cancer, Habana, 1949, 24: 3-9. 12 refs. 43Â« Althoff, H. ZUR URETHANBEHANDLUNGDER CHRO NISCHEN MYELOISCHEN LEUKÃ„MIE IM KINDESALTER. [URETHANE TREATMENT OF CHRONIC MYELOID LEU KEMIA IN CHILDHOOD.] Mschr. Kindern., 1951, 99: 442-444. 21 refs. Abstracted in: Chem. A~6str., 1952, 46: 3657a. 439 Alwall, N. URETHANE IN MULTIPLE MYELOMA 1. FINAL REPORT OF A CASE TREATED MORE THAN FOUR YEARS WITH URETHANE. Acta med. scand., 1952, 144: 114-118. 440 . Amon, A. DIE BEHANDLUNG DES RETOTHELSARKOM MIT URETHAN. [URETHANE TREATMENT OF THE RETÃ•CULO SARCOMA]. 35 1. 1948. (Inaug.- Diss., MUnchen) . 29 refs. Typewritten. Review. 441 Anglesio, D. RELAZIONE SULLA CASISTICA DI PAZIENTI TRATTATI CON URETANO E CON CLORO- AZO-IPRITE. [CASE REPORTS OF PATIENTS TREATED WITH URETHANE AND WITH NITROGEN MUSTARD]. Minerva med., Tor , 1949, 40- pt. 2, 314-315. 442 Arsenijevic, li., RadojÃ¯ic, B. and Antic, M. HRONICNE MIJELOZE LECENE URETANOM. [CHRONIC MYELOSIS TREATED WITH URETHANE.] Voj . San. pregi., Beogr., 1953, 10: 130-5. 8 refs. Urethane in doses of 3^i g. over a period of five weeks, was administered per os to five patients. In three cases without any previous treatment complete clinical and hematological remission ensued. Remissions lasted up to 15 months when urethane, in daily doses of 2 g at least twice a week, was given following an intense initial treatment with the drug. Ayrea, O. DAS LEUKOCITEMIAS. [LEUKEMIAS] Impr. med.. Rio, 1952, 28: 29-33. Abstracted in: Leukemia Abstr., 1957, 1^:No. 245. "Ci tations from several authors on leukemia are followed by a report of one case. In a 21- year-old woman, fever and ascendent edema ap peared a few days after childbirth (October 1949). Hospitalized, she was treated for acute myeloid leukemia with urethane, nicotinic acid, and complex B, producing tempo rary improvements. The temperature was elevated and fluctuating during all the stages of the disease. The patient died in December 1951." - Leukemia Abstr. 444 Aznar Reig, A., Llogregat Gonzalez, N., Viejo Fonteli, A. and Torres Ruiz, A. EL URETANO EN EL TRATAMIENTO DE LAS LEUCEMIAS CRÃ“NICAS. [URETHANE THERAPY OF CHRONIC LEUKEMIAS.] Medicina, Madr., 1948, 1(5: 310-328. tab. 14 refs. Four cases. 445 Batir, E. ZUR DAUERBEHANDLUNG DER CHRONISCHEN MYELOISCHEN LEUKÃ„MIE MIT URETHAN. [PROLONGED URETHANE THERAPY OF CHRONIC MYELOID LEUKEMIA.) Arch. inn. Med., 1951, U 692-698. 17 refs. 446 Bedinger, P. L. FURTHER STUDIES ON THE EFFECT OF URETHANE ON LEUCEMIA. J. Laborat. Clin. M., 1948, 33: 1647-1648. Study of 85 cases. 447 Bedinger, P. L., Poncher. H. G. and Limarzi, L. R. EFFECT OF URETHANE ON LEUCEMIA. J. Laborat. Clin. M., 1947, 3_2: 1393-1395. It is concluded from this clTnical study that: "(1) in patients with acute leucemia urethane in oral doses of 1 to 5 Gm. daily will produce moderate to marked fall in the leucocyte count during a period of one to several weeks; (2) in patients with chronic lymphatic leucemia and chronic myeloid leucemia there is a tendency for the blood pattern to approach a more mature type with a decrease in the size of the lymph nodes and spleen; (3) the temporary remission induced by the drug in chronic leucemia is never as complete as that fol lowing roentgen therapy; (4) there is no indication that urethane has any permanent effect on the leucemie process." 448 Belaisch, J. LE LEUCOSE MYELOIDE ET SON TRAITE MENT [MYELOID LEUKEMIA AND ITS TREATMENT] . Bull, mÃ©Ã .,Par., 1954, 68: 123-124. 44Berman, L. and Axelrod, A. R. EFFECT OF URETHANE ON MALIGNANT DISEASES; CLINICAL, HEMATOLOGIC AND HISTOLOGIC OBSERVATIONS ON PATIENTS WITH CARCINOMA, LEUKEMIA AND RELATED DISEASES. Am. J. Clin. Path., 1948, 18: 104-129. 27 refs. Abstracted in: Excerpta medT, Sect. 5, 1949, 21 No. 2005. 450 Berman, L., Axelrod, A. R., Sharp, E. A. and Vonder Heide, E. C. EXPERIENCES WITH URETHANE IN EIGHT PATIENTS WITH MALIGNANT DISEASE. Proc. Centr. Soc. Clin. Res.. 1947, 20: 40- 41. Also in: J. Laborat. Clin. M., T947, 32: 1431-1432. 451 ,, Bernard, A. TRAITEMENT D'UNE LEUCEMIE MYELOIDE PAR L'URETHANE. [URETHANE TREATMENT OF MYELOID LEUKEMIA]. J. se. mÃ©d. Lille, 1947, 65: 496- 499. 452 Bernard, A. LE TRAITEMENT DES LEUCEMIES WVFJ.Olm:s PAR L1 URETHANE. [URETHANE TREATMENT IN HYELOID LEUKEMIA]. J. BC. mÃ©d. Lille, 1951, 69: 119- 122. 453 Bisotti, P. L. and Tinozzi, C. C. SULLA PRETESA AZIONE TERAPEUTICA DELL'ETILURETANO NEI TUMORI MALIGNI. [SUPPOSED THERAPEUTIC EFFECT OF ETHYL URETHANE ON Tor., 1949, MALIGNANT TUMORS.] 40: pt. 2, 36-38. Minerva 16 refs. med., Findings basecT on results in 7 cases indicated negative effect of ethylurethane.
Downloaded from cancerres.aacrjournals.org on August 30, 2013. © 1956 American Association for Cancer Research. 30 CARBAMATE, ETHYL â€”¿ THERAPY (Continued) 454 Bock, H. E. BEHANDLUNG AUCH NICHT-LEUKÃ„MISCHER ERKRANKUNGEN, INSBESONDERE DER LYMOHOGRANULO- HATOSE, HIT URETHAN NEBST BEMERKUNGEN ÃœBER DEN MECHANISMUS DER URETHANWIRKUNG. [URETHANE TREATMENT OF NON-LEUKEMIC DISEASES, ESPECIALLY LYMPHOGRANULOMATOSIS, WITH COMMENTS ON THE MECHANISM OF ACTION OF URETHANE.] Klin. Wschr., 1948, 26: 390-396. 28 rets. Urethane in daily doses Ã–T 1-8 g, usually 4-6 g, given by mouth or by rectum had no effect on the following conditions: hypernephroma, gastric carcinoma, liver tumors, lung tumors and multiple myeloma. It gave temporary regression in Hodgkin's disease; striking results in patients with lymphogranulomatosis. Urethane is to be con sidered primarily as a nuclear poison, rather than a mitotic one. 455 Bock, H. E. and Gross, R. ERGEBNISSE ZWEIJÃ„HRI GER URETHANBEHANDLUNGBEI LEUKOSEN. (1946- 1948). I. CHRONISCHE MYELOSEN. [TWO YEARS' EXPERIENCE WITH URETHANE THERAPY OF LEUKOSES. (1946-1948). I. CHRONIC MYELOSES]. Deut. med. Wschr., 1949, 74: 953-958. 456 Bock, H. E. and Gross, R. ERGEBNISSE ZWEI- JAHRIGER URETHANBEHANDLUNG BEI LEUKOSEN (1946-1948). II. CHRONISCHE LYMPHADENOSEN (MIT SARKOMOTOSEN IM LYMPHATISCHEN SYSTEM). [TWO YEARS' EXPERIENCES WITH URETHANE THERA PY OF LEUKOSES (1946-1948). H. CHRONIC LYMPHADENOSES (WITH SARCOMATOSIS OF LYMPHA TIC SYSTEM).] Deut. med. Wschr., 1949, 74: 995-1000. Bibliography, p: 999-1000. 457 Bock, H. E. and Gross, R. MÃ–GLICHKEITEN UND GRENZEN EINER URETHANBEHANDLUNGBEI MORBUS HODGKIN (LYMPHOGRANULOMATOSE), AUCH BEI KOMBINATION MIT TUBERKULOSE. [POSSIBILITIES AND LIMITATIONS OF URETHANE TREATMENT OF HODGKIN'S DISEASE ALONE, AND COMPLICATED BY TUBERCULOSIS.] ^47: 303-323. Zschr. Appro*. klin. Med., 80 refs. 1950, 458 Bock, H. E. and Gross, R. 'ÃœBERDIE URETHAN BEHANDLUNG BEI BLUTKRANKHEITEN, BESONDERS BEI LEUKOSEN. [URETHAN TREATMENT IN BLOOD DISORDERS, ESPECIALLY IN LEUKEMIAS.] Aerztl. Forsch., 1947, 1J Originalarb., 369-380. 55 refs. Abstracted in: Chem. Abstr., 1951, 45: No. 3944e. 459 Bock, H. E., Gross, R. and Riethmuller, H. U. A'HNLICHKEITEN UND UNTERSCHIEDE IN DER WIR KUNG VON URETHAN UND MUSTARD-NITROGEN (N- LOSTl. [SIMILARITIES AND DIFFERENCES IN ACTION OF URETHANE AND NITROGEN MUSTARD] . Verb. Deut. Ges. inn. Med., 1949, 55: 389- 395. 460 Bonora, G. LA TERAPIA DELLE LEUCEMIE CON L'URE- TANO; CONTRIBUTO CLÃ•NICO. [TREATMENT OF LEU KEMIA WITH URETHANE; CLINICAL CONTRIBUTION.] Riv. pat. clin., Parma, 1949, 4: 364-379. 22 refs. five case histories. Burgstedt, H. NEUERE BEHANDLUNGSVERFAHREN BEI DER LEUKÃ„MIE DES KINDES. [NEW METHODS OF TREATING LEUKAEMIA IN CHILDREN.] Munch, med. Wschr., 1952, 94: 1468-1475. 26 refs. "The effect of various therapeutic measures based on different pathogenic theories was tested in 50 cases of leukaemia in children...Among the cytostatic drugs, the estrogens and some resting nuclear poisons such as urethan, nirvanol and nitrogen mustard had an unfavour able effect on the affection and are therefore contra-indicated. Treatment with ACTH and anti-folic acid compounds resulted in re mission in 20-50% of cases and considerably increased the survival time. A true cure, however, has so far not been obtained." 462 CaBon Raby, A. TRATAMIENTO DE LAS LEUCEMIAS CON URETANO. URETHANE TREATMENT OF LEUKE MIA] . 70p. Santiago, 1947. (Tesis-Univ. de Chile). 14 refs. Nine case histories of patients with chronic myeloid leukemia ob served from 3-9 months and one with acute myeloblastic leukemia are presented. Course of treatment is described. 463 Cervini, C. CASI DI EMOBLASTOSI TRATTATI CON ETILURETANO E CONSIDERAZIONI CLINICHE ED EMATOLOGICHE SULLA TERAPIA URETANICA IN GENERE. [HEMOBLASTOSIS TREATED WITH ETHYL URETHANE; CLINICAL AND HEMATOLOGIC STUDY OF URETHANE THERAPY.] Clin, nuova, Roma, 1949, 9: 175-195. 70 refs. Six cases. 464 Chini, V. PAZIENTI TRATTATI CON SOSTANZE CITO- STATICHE NELLA CLÃ•NICA MEDICA DI BARI. [PATIENTS TREATED WITH CYTOSTATIC SUBSTANCES IN THE MEDICAL CLINIC OF BARI.] Minerva med., Tor., 1949, 40: pt. 2, 313. 465 Cifarelli, E. RELAZIONE SU OTTO CASI DI LEU CEMIA ACUTA SOTTOPOSTI A TRATTAMENTO CON URE TANO ETILICO PER VIA ORALE. [REPORT ON LIGHT CASES OF ACUTE LEUKEMIA TREATED ORALLY WITH ETHYLURETHANE.] Minerva med., Tor., 1949 40: pt. 2, 287-289. 466 Ciurdariu, P., loanovici, G., Canea, N. and SÃ¢rbu, I. TRATAMENTAL LEUCEMIEI CRONICE CU URETHAN. [TREATMENT OF CHRONIC LEUKEMIA WITH URETHANE.] Ardeal. med., Cluj, 1949, 8: 125-6. Urethane in doses of 0.5-1 g per day administered to 3 patients with chronic leukemia decreased the leucocyte count and in general modified the blood pic ture . 467 Cooper, T. amd Watkins, C. H. ETHYL CARBAMATE (URETHANE) IN THE TREATMENT OF CHRONIC MYELOCYTIC LEUKEMIA; RESULTS OF A 3 YEAR STUDY. Med Clin N. America, 1950, 34: 1205-1215. 24 refs. 468 Creskoff, A. J., Fitz-Hugh, T., Jr., and Frost, J. W. URETHANE THERAPY IN LEUKEMIA. Blood, N. Y., 1948, 3: 896-910. 3 refs. Abstracted in: Biol. Abstr., Bait., 1949, 23: No. 7225. Briefer treatment of this reporVappears with discussion in: Rev. Gastroenter., N. Y 1949, 16: 243-249. 469 Debray, J. L'URETHANE DANS LES MALADIES DU SANG. [URETHANE IN THERAPY OF BLOOD DISEASES.] Sem. hop. Paris, 1950, 26: 1228-1230. 18 refs. A short review. 470 Derifield, R. S. THE EFFECT OF URETHANE IN MULTIPLE MYELOMA; REPORT OF 4 CASES. J. Iowa M. Soc., 1950, 40: 220-223. 9 refs. Treat ment starting wTÃ®h 3 gm of urethane daily and reducing it to 1 gm daily until a maxi mum dosage of 388 g of urethane was reached, resulted in clinical and histl/logical im provements in 4 patients. Toxic effects did not necessitate discontinuance of therapy.
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CANCER CHEMOTHERAPY ACENAPHTHENE ... - Cancer Research

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