CANCER CHEMOTHERAPY ACENAPHTHENE ... - Cancer Research

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Downloaded from cancerres.aacrjournals.org on August 30, 2013. © 1956 American Association for Cancer Research. 49 COLCHICINE â€”¿METABOLISM (INCLUDING EFFECTS ON METABOLIC PROCESSES) 807 Back, A. and Walaszek, E. J. FIXATION OF RADIO ACTIVE COLCHICINE BY EHRLICH ASCITES CARCINOMA CELLS. Nature, Lond., 1953, 172: 202-203. The quantity fixed seemed to b~ein accord with the amount needed to give a karyoclastic in fluence on cells. 808 Back, A. and Walaszek, E. J. STUDIES WITH RADIOACTIVE COLCHICINE. I. THE INFLUENCE OF TUMORS ON THE TISSUE DISTRIBUTION OF RADIOACTIVE Res., 1953, COLCHICINE IN MICE. Cancer 13: 552-555. 17 refs. Radio active colchiclne accumulated in signifi cant amounts in the spleens of normal mice while none was found in spleens of tumorbearing mice. The intestines of tumorbearing mice accumulated more colchicine than intestines of normal mice. Lyophilized tumor tissue, when injected into normal mice had an action similar to that of a tumor in situ. 809 Back, A., Walaszek, E. and Uyeki, E. DISTRIBUTION OF RADIOACTIVE COLCHICINE IN SOME ORGANS OF NORMAL AND TUMOR-BEARING MICE. Proc. Soc. Exp. Biol., N. Y., 1951, 77: 667-669. 5 refs. Abstracted in: Excerpta med., Sect. 2, 1952, 5: No. 4007; Chem. Abstr., 1951, 45: No. 10357ÃŒ. 810 Bass, A. D.and Place, E. F. URIC ACID AND ALLANTOIN EXCRETION IN NORMAL AND TUMOR- BEARING MICE. J. Biol. Chem., 1949, 181: 81-87. 13 refs. Abstracted in: Chenu Abstr., 1950, 44: 2634d. 811 Bloch, D. P. EFFECT OF COLCHICINE ON SYNTHESIS OF DESOXYRIBONUCLEIC ACID IN TISSUE CULTURED RAT FIBROBLASTS. Proc. Soc. 1953, 83: 341-346. 12 refs. Exp. Biol., Colchicine N. Y., does not directly inhibit DNA synthesis. 812 Ebner, H. and Strecker, H. ÃœBER DIE WIRKUNG DES COLCHICINS IN VIVO AUF DIE ALKALISCHE PHOSPHATASE DER RATTENLEBER. [EFFECT OF COLCHICINE IN VIVO ON THE ALKALINE PHOS PHATASE OF RAT LIVER]. Experientia, Basel, 1950, 6: 388-389. 14 refs. Abstracted in: Excerpta med., Sect. 2, 1951, 4: No. 2742. 813 Ferguson, F. C., Jr. COLCHICINE. II. META BOLISM OF FROG SKELETAL MUSCLE. Exp. Ther., 1953, 108: 186-200. J. Pharm. tab. 14 refs. 814 Frei, W. and Brunner, T. BEZIEHUNGEN ZWISCHEN ZELLTEILUNG UND OXYDATION BEI BAKTERIEN. SCHÃ„DIGUNG DER AEROBEN UND ANAEROBEN OXY DATION VON BAKTERIEN MIT CYANKALI, PYRIDIN, COLCHICIN UND ULTHAVIOLETTSTRAHLEN. [RELA TION BETWEEN CELL DIVISION AND OXIDATION PROCESSES IN BACTERIA. INTERFERENCE WITH AEROBIC AND ANAEROBIC OXIDATION IN BACTERIA BY CYANIDE, PYRIDINE, COLCHICINE, AND ULTRA VIOLET IRRADIATION.] Helv. physiol. pharm. acta, pecially: 1947, p.~260. 5j 252-264. Abstracted 7 refs. in: Cbera. See es Abstr., 1948, 42: 943Ã•. "The above agents inhibit oxidation processes in bacteria, yeasts and trichomonads and thereby decrease the rate of cell division." -Chem. Abstr. 815 Grixoni, F. RICERCHE ISTOCHIMICHE SUL METABO LISMO DEGLI ACIDI NUCLEINICI NEGLI EPITE LIOMI BASOCELLULARI CUTANEI TRATTATI CON APPLICAZIONI EPITOPICHE DI COLCHICINA. [HISTO- CHEMICAL RESEARCH ON THE METABOLISM OF NUCLEIC ACIDS IN BASAL CELL CARCINOMA OF THE SKIN TREATED WITH EXTERNAL APPLICATIONS OF COLCHI CINE.] Minerva derm., Tor., 1953, 28: 6-10. Abstracted in: Excerpta ned., Sect. 16, 1954, 2: No. 4830. 816 Keibl, E. and Spitzy, K. H. ZUM PROBLEM DES LEUKOZYTENSTOFFWECHSELS. 2. EINFLUSS VON HONTGENSTRAHLEN, DEN STOFFWECHSEL URETHAN UND COLCHIZIN MYELOISCH-LEUKAMISCHER AUF ZELLEN. BOLISM. [THE PROBLEM OF LEUCOCYTES META 2. EFFECTS OF X-RAYS, URETHANE AND COLCHICINE ON THE METABOLISM OF MYELOID LEUKEMIC CELLS.] Arch. exp. Path., Beri., 1951, 213: 365-372. 52 refs. Abstracted in: Excerpta med., Sect. 2, 1952, 5: No. 4413. 817 Klein, G., Klein, E. and Klein, E. THE VIABILITY AND THE AVERAGE DESOXYPENTOSENUCLEIC TENT OF MICRONUCLEI-CONTAINING CELLS ACID CON PRODUCED BY COLCHICINE TREATMENT IN THE EHRLICH ASCITES TUMORS. Cancer Res., 1952, 1^: 484-489. 1 pi. 24 refs. Abstracted in: Chem. Abstr., 1952, 46: No. 10444d. 818 Lang, K., Siebert, G. and Estelmann, W. HEMMUNG DER ADENOSINTRIPHOSPHATASE DURCH COLCHICIN. [INHIBITION OF ADENOSINE TRIPHOSPHATASE BY COLCHICINE.] Experientia, Basel, 1951, 7: 379-380. 8 refs. 819 Lang, K., Siebert, G. and Oswald, H. ÃœBER DIE HEMMUNG VON DESOXYHIBONUCLEOTIDE SPALTENDEN FERMENTEN DURCH COLCHICIN. DESOXYNUCLEOTIDE-SPLITTING [INHIBITION OF ENZYMES BY COL CHICINE.] Experientia, Basel, 1949, 5: 449. 5 refs. Abstracted in: Chem. Abstr., 1950, 44: 4523Ã•. 820 Milletti, A. STUDI SUL METABOLISMO PROTEICO CELLULARE; CONFRONTO TRA IL MECCANISMO DI AZIONE DI SOSTANZE AD AZIONE MITOCLASICA DIVERSA (COLCHICINA, CLORAMIN, TRIPAFLAVINA). [CELLULAR PROTEIN METABOLISM. INFLUENCE OF SUBSTANCES OF MITOCLASTIC ACTION (COLCHICINE, CHLORAMINE, TRYPAFLAVINE).] Bologna, 1951, 20: 284-288. Endocr. sc. cost., Abstracted in: Chem. Abstr., 1352, 46: 6752ÃŒ. 821 Â«Muletti, A. STUDI SUL METABOLISMO PROTEICO CELLULARE. INFLUENZA DELLA COLCHICINA SULLA STRUTTURA MORFOLOGICA E CITOCHIMICA DELLE CELLULE SIEROSE. [STUDIES ON CELLULAR META BOLISM OF PROTEINS. EFFECT OF COLCHICINE ON THE MORPHOLOGICAL AND CYTOCHEMICAL CHARACTERS OF SEROUS CELLS.] Bull. Sc. med., Bologna, 1951, 123: 288-291. 822 Schoetensack, W. BEEINFLUSSUNG VON PHOSPHATASEN DURCH MITOSEGIFTE. [EFFECT OF MITOTIC POISONS ON PHOSPHATASES.] Naturwissenschaften, 1948, 35: 285. 5 refs. Abstracted in: Chem. Abstr., T9~50, 44: 3148g. 823 Schoetensack, W. ZUR KENNTNIS DER COLCHICIN- WIRKUNGEN. [EFFECTS OF COLCHICINE.] Arch, exp. Path., Beri., 1950, 212: 117-118. See 27 121 394 743 2208 3574 MODE OF ACTION 824 Â»Costa, E., Pani, M. L. and Napoleone, C. INTORNO AL MECCANISMO DELL'EFFETTO LEUCOCITOSSICO DELLA COLCHICINA. [MECHANISM OF THE LEUKOCYTOSIS EFFECT OF COLCHICINE.] Boll. Soc. ital. biol sper., 1951, 27: 1647-1648. 825 Mugler, A. COLCHICINE ET ACTH. [COLCHICINE AND ACTH.] Sem. hSp. Paris, 1952, 28: 136- 138. 16 refs.
Downloaded from cancerres.aacrjournals.org on August 30, 2013. © 1956 American Association for Cancer Research. 50 COLCHICINE â€”¿MODE OF ACTION (Continued) 826 Roques, H. MODES D'ACTION DE LA COLCHICI NE SUR LES TUMEURS A VIRUS. [ACTION 0F COLCHICINE ON VIRUS TUMORS.] Bull, algÃ©r. carcin., 1951, 4: 146-150. Abstracted In: Excerpta med., Sect. 5, 1952, 5: No. 2702. 827 Wldmann, H. TIEREXPERIMENTELLE UNTERSUCHUNGEN ÃœBER DEN WIRKUNGSMECHANISMUS DES COLCHICINS IN LETALEN UND SUBLETALEN DOSEN AUF BLUT UND KNOCHENMARK. [EXPERIMENTAL STUDIES ON THE MODE OF ACTION OF LETHAL AND SUBLETHAL DOSES OF COLCHICINE ON BLOOD AND BONE MARROW.] Arch. exp. Path. Lpz., 1949, 207: 218-242. Approx. 40 reÃa. Abstracted In: Excerpta med., Sect. 2, 1951, 4: No. 1619. 828 Wldmann, H. TIEREXPERIMENTELLE UNTERSUCHUNGEN ZUR Ã„TIOLOGIE DER LEUCOPENISCHEN PHASE NACH COLCHICINE. [EXPERIMENTAL ANIMAL STUDIES ON THE ETIOLOGY OF THE LEUCOPENIC PHASE FOLLOWING COLCHICINE ADMINISTRATION.] Fol. haemat., Lpz., 1952, 71; 257-266. 19 refs. 829 Widmann, H. and Sauter, H. D. DAS SYNDROM DER ALLGEMEINEN ANPASSUNG VON H. SELYE, SEINE BEZIEHUNGEN ZUR LEUKOPOESE UND ZU DEN LEUKO ZYTENBEWEGUNGEN NACH COLCHICININJEKTIONEN. [SELYE'S ADAPTATION SYNDROME AND ITS RELA TIONSHIP TO LEUCOCYTOPOIESIS AND THE LEUCO CYTE CHANGES FOLLOWING INJECTION OF COLCHI CINE.] Zschr. ges. inn. Med., 1952, 7: 170- 177. 10 refs. Abstracted in: Excerpta med., Sect. 3, 1952, 6: No. 1960, "The effect of colchicine on th~e blood picture of rats is See discussed in detail. The intensity of leu cocyte changes observed in adrenalectomized animals was largely dependent on the general condition. But in general the effect was similar to that observed in normal animals. This leads to the conclusion that the effect of colchicine on the leucocyte blood picture is not based on an anterior pituitary-adrenocortical stress mechanism. It is contended that colchicine exerts a direct influence on the bone marrow and the leucocytes, which gives rise to leucocyte changes resembling those seen in the adaptation syndrome." -Excerpta med. 29 122 2950 3107 PHARMACOLOGICAL AND PHYSIOLOGICAL EFFECTS 830 BarÃ¡ny, E. and Palis, A. HEMMUNG DES VIS- KOSITÃ„TSABFALLES IN ATP-ACTOMYOSIN-MISCHUNGEN DURCH COLCHICIN. [INHIBITION OF THE VISCOSITY DECREASE IN ATP-ACTOMYOSIN MIXTURES BY COLCHI CINE.] The viscosity Naturwisschenschaften, of actomyosin solutions~Tpre- 1951, 38: 547. pared from heart muscle) decreases upon the addition of ATP. This effect can be partially inhibited by the addition of colchicine. 831 BrÃ¤m, A. ZUM VERHALTEN DER MITOCHONDRIEN BEI EINWIRKUNG VERSCHIEDENER PHARMAKA. UNTER SUCHUNGEN MIT DEM PHASENKONTRASTMIKROSKOP AN GEWEBEKULTUREN. [EFFECT OF VARIOUS DRUGS ON MITOCHONDRIA; TISSUE CULTURE STUDIES BY MEANS OF PHASE CONTRAST MICROSCOPY.] Acta anat., Basel, 1951, 1_3: 385-402. Bibliography: p. 401-402. English summary. Study includes colchicine, nicotine, arsenic, trypaflavine and nitrogen mustard and a review of the literature. 832 if, Comi, G. and Arcangeli, P. L1INTRADERMOREAZIONE ALLA COLCHICINA. NOTA I. CONSIDERAZIONI GENERALI SULL'ASPETTO, SUL COMPORTAMENTOE SUL SIGNIFICATO DELLA MEDESIMA. [THE INTRA- DERMAL REACTION TO COLCHICINE. NOTE I. GENERAL CONSIDERATIONS ON ITS APPEARANCE, BEHAVIOR AND SIGNIFICANCE]. Margin, derm., Fir., 1949, 4: 78-93. 833 Ferguson, F. C. COLCHICINE. I. GENERAL PHARMA COLOGY. J. Pharm. Exp. Ther., 1952, 106: 261- 270. 12 refs. 834 Carotalo, F. AZIONE DELLA COLCHICINA SULLA RESPIRAZIONE DI ALCUNE SPECIE BATTERICHE. [EFFECT OF COLCHICINE ON CERTAIN BACTERIA]. Gior. batt. immun., 1947, 36: 102-104. 3 refs. English summary. 835 Goodman, G. C. and Murray, M. R. INFLUENCE OF COLCHICINE ON THE FORM OF SKELETAL MUSCLE IN TISSUE CULTURE. Proc. Soc. Exp. Biol., N. 1953, 84: 668-672. 15 refs. "Colchicine Y., causesTT.a breaking-up of the sarcoblastic ribbons into short widened segments of ap parently decreased consistency. ments remain viable." These seg 836 Grampa, G. OSSERVAZIONI COL MICROSCOPIO A CONTRASTO DI FASE SUL CONDRIOMA DELLE CELLULE EPATICHE IN REGENERAZIONE SPERIMENTALE. [OB SERVATIONS WITH THE PHASE MICROSCOPE ON THE HEPATIC CELL CHONDRIOMA IN EXPERIMENTAL RE GENERATION.] Boll. Soc. ital. biol. Sper., 1951, 27: 808-809. pi. 3 refs. 837 Grampa, G. and Dustin, P., Jr. IMPIEGO ASSO CIATO DI AMINOPTERINA E COLCHICINA E ANOMALIE NUCLEARI; .RICERCHE SPERIMENTALI SULL' INTESTINO DEL TOPO. [COMBINED USE OF AMINOPTERIN AND COLCHICINE IN THE STUDY OF NUCLEAR ABNORMALI TIES; EXPERIMENTAL STUDIES ON THE INTESTINE IN MOUSE.) Tumori, Milano, 1953, 39: 63-71. 14 refs. English summary. The cyÃ®ological alterations produced by aminopterin on mouse's intestine were determined by the use of col chicine. The findings are described. 838 Hamperl, H. UEBER CHRONISCHE COLCHICINWIRKUNG. [CHRONIC EFFECT OF COLCHICINE.] Klin. & Prax., Munch., 1946, \\ 186-187. 7 refs. 839 Keibl, E. and Bichlbauer, U. tJBER DIE WIRKUNG DES COLCHICINS AUF DIE THROMBOPOIESE. [EF FECT OF COLCHICINE ON THROMBOCYTOPOIESIS.] Klin. Med. Wien, 1949, 4: 517-522. 16 refs. Abstracted in: Excerpta med., Sect. 2, 1950, 3: No. 944. 840 Koskowski, W. and Mahfouz, M. THE INHIBITORY EFFECTS OF COLCHICINE ON THE GASTRIC SECRE TION PRODUCED BY HISTAMINE AND OTHER SECRE- TAGOGUES. J. Pharm. Exp. Ther., 1953, 109: 361-365. 7 refs. Abstracted in: Chem. Abstr., 1954, 48: 5353a. 841 Lehmann, F. E. ÃœBERDIE ENTWICKLUNGSPHYSIO LOGISCHE WIRKUNG DES COLCHICINS. [THE EFFECT OF COLCHICINE ON DEVELOPMENTAL PHYSIOLOGY.] Arch. Julius Klaus Stift., 1946, 21: 305- 307. 842 Â»Merlini, A. AZIONE DELLA COLCHICINA SULL'EMO POIESI. [EFFECT OF COLCHICINE ON HEMATOPO- IESIS.] Arch. Maragliano pat. clin., 1948, 3: 1639-1692. 843 Miszurski, B. EFFECTS OF COLCHICINE ON RESTING CELLS IN TISSUE CULTURES. Exp. Cell Res., 1949, Suppl. 1, 450-451. 2 refs. 844 Miszurski, B. and Doljanski, L. EFFECT OF COL CHICINE ON RESTING CELLS IN TISSUE CULTURES. Proc. Soc. Exp. Biol., N. Y., 1947, 64: 334- 336. Abstracted in: Excerpta med., Sect. 2, 1948, 1: No. 2698; Chem. Abstr., 1947, 41: 4180b.~
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