Cleveland Clinic Brain Tumor and Neuro-Oncology Center Clinical ...
Cleveland Clinic Brain Tumor and Neuro-Oncology Center Clinical ...
Cleveland Clinic Brain Tumor and Neuro-Oncology Center Clinical ...
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<strong>Clevel<strong>and</strong></strong> <strong>Clinic</strong> <strong>Brain</strong> <strong>Tumor</strong> <strong>and</strong> <strong>Neuro</strong>-<strong>Oncology</strong> <strong>Center</strong>:Patient Data<br />
http://bti.ccf.org/cgi-bin/bti/auth/detailLAMINATE.cgi?id=613<br />
Page 1 of 4<br />
4/11/2013<br />
<strong>Clevel<strong>and</strong></strong> <strong>Clinic</strong> <strong>Brain</strong> <strong>Tumor</strong> <strong>and</strong> <strong>Neuro</strong>-<strong>Oncology</strong> <strong>Center</strong><br />
<strong>Clinic</strong>al Database<br />
Open <strong>Clinic</strong>al Protocols Information<br />
CCF IRB CC945<br />
RTOG 0834<br />
Full Title<br />
P.I.<br />
Phase III Trial on Concurrent <strong>and</strong> Adjuvant Temozolomide Chemotherapy in Non-1p/19q Deleted<br />
Anaplastic Glioma. The CATNON Intergroup Trial.<br />
Samuel Chao, M.D.<br />
Primary objectives<br />
• To assess whether concurrent radiotherapy with daily temozolomide chemotherapy improves overall survival<br />
as compared to no daily temozolomide in patients with non-1p/19q deleted anaplastic glioma.<br />
• To assess whether adjuvant temozolomide chemotherapy improves survival as compared to no adjuvant<br />
temozolomide chemotherapy in patients with non-1p/19q deleted anaplastic glioma<br />
Objectives<br />
Secondary objectives<br />
• To assess whether concurrent <strong>and</strong> adjuvant temozolomide treatment prolongs progression free survival <strong>and</strong><br />
neurological deterioration free survival in patients with non-1p/19q deleted anaplastic glioma.<br />
• To assess the safety of concurrent <strong>and</strong> adjuvant temozolomide in patients with non-1p/19q deleted<br />
anaplastic glioma, including late effects on cognition.<br />
• To assess the impact of concurrent <strong>and</strong> adjuvant temozolomide treatment on the quality of life in patients<br />
with non-1p/19q deleted anaplastic glioma.