Rheumatoid Arthritis
Rheumatoid Arthritis
Rheumatoid Arthritis
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Mechanisms of joint damage<br />
• Synovial mass stretches joint capsule and<br />
ligaments: joint swelling, instability &<br />
deformity<br />
• Cytokine and proteolytic enzyme rich synovial<br />
fluid destroys cartilage joint space<br />
narrowing on X-rays<br />
• Infiltration of cartilage and later bone by<br />
invading synovium (pannus)<br />
marginal erosions