Dr. Kai Matuschewski Department of Parasitology ... - HBIGS

Dr. Kai Matuschewski
Department of Parasitology
University of Heidelberg
69120 Heidelberg, Germany
Phone: +49-(0)6221-56 8284
Fax: +49-(0)6221-56 4643
Email: Kai.Matuschewski@med.uni-heidelberg.de
02/03/1966, Berlin-Neukölln
CURRICULUM VITAE
2007 Offer for W3-Professorship at Dept. of Parasitology, University of
Heidelberg
2006 Offer for Senior Investigator at Sanger Centre, Cambridge (declined).
2006 Offer for Full Professorship at Hannover Medical School (declined).
2001 – present Junior Group Leader at Dept. of Parasitology, University of Heidelberg.
1998 – 2001 Postdoctoral fellow at New York University School of Medicine. Supervisor:
Victor Nussenzweig, MD, PhD.
1994 – 1998 PhD thesis at Center of Molecular Biology Heidelberg (ZMBH). Supervisor:
Prof. Dr. Stefan Jentsch.
1993 – 1994 Diploma project at Friedrich-Miescher Laboratory of the Max-Planck
Society, Tübingen and ZMBH, Heidelberg. Supervisor: Prof. Dr. Stefan
Jentsch.
1987 – 1993 Biochemistry studies at Eberhard-Karls-University, Tübingen
HONORS
2006 Chica und Heinz Schaller Forschungspreis (CHS Stiftung)
2006 Joachim Siebeneicher Forschungspreis zu biomedizinischer Forschung
(Joachim Siebeneicher Stiftung)
2005 Deutscher Preis für Tropenmedizin (Deutsche Gesellschaft für
Tropenmedizin und internationale Gesundheit)
FIELDS OF INTEREST
Cellular microbiology, malaria, host-pathogen interactions, vaccine development.
CURRENTLY FUNDED PROJECTS
SFB544, project B10; DFG-SPP1131; EU-funded Network of Excellence BIOMALPAR;
FNIH: Grand Challenges of Global Health.

PUBLICATIONS (10 most important publications):
Matuschewski K (2006) Vaccine development against malaria. Curr Opin Immunol 18: 449-
457.
Schüler H, Mueller AK, Matuschewski K (2005) A Plasmodium actin depolymerizing factor
that binds exclusively to actin monomers. Mol Biol Cell 16: 4013-4023.
Aly ASI, Matuschewski K (2005) A malarial cysteine protease is necessary for Plasmodium
sporozoite egress from oocysts. J Exp Med 202: 225-230.
Mueller AK, Camargo N, Kaiser K, Andorfer C, Frevert U, Matuschewski K, Kappe SHI
(2005) Plasmodium liver stage developmental arrest by depletion of a protein at the parasitehost
interface. Proc Natl Acad Sci USA 102: 3022-3027.
Mueller AK, Labaied M, Kappe SHI, Matuschewski K (2005) Genetically modified
Plasmodium parasites as a protective experimental malaria vaccine. Nature 433: 164-167.
Matuschewski K, Ross J, Brown S, Kaiser K, Nussenzweig V, Kappe SHI (2002) Infectivityassociated
changes in the transcriptional repertoire of the malaria parasite sporozoite stage.
J Biol Chem 277: 41948-41953.
Matuschewski K, Nunes AC, Nussenzweig V, Ménard R (2002) Plasmodium sporozoite
invasion of insect and mammalian cells is directed by the same dual binding system. EMBO
J 21: 1597-1606.
Braun S, Matuschewski K, Rape M, Thoms S, Jentsch S (2002) Role of the ubiquitinselective
CDC48 UFD1/NPL4 chaperone (segregase) in ERAD of OLE1 and other substrates.
EMBO J 21: 615-621.
Hoppe T, Matuschewski K, Rape M, Schlenker S, Ulrich HD, Jentsch S (2000) Activation of a
membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent
processing. Cell 102: 577-586.
Matuschewski K, Hauser HP, Treier M, Jentsch S (1996) Identification of a novel family of
ubiquitin-conjugating enzymes with distinct amino-terminal extensions. J Biol Chem 271:
2789 – 2794.

EXPERIENCE IN THE SUPERVISION OF DOCTORAL CANDIDATES
Supervised 5 doctoral theses
SUPERVISED DISSERTATIONS (last 5 years)
Marion Steinbüchel, PhD (2006). Molecular mechanisms of Plasmodium-Anopheles
interactions. University of Heidelberg.
Current Occupation: Investigator, Clinical Trials Center, Mannheim.
Kirsten Heiss, PhD (2006). Funktional characterization of TRAP invasins in Plasmodium and
identification of a potential merozoite invasin. University of Heidelberg.
Current Occupation: Postdoctoral Fellow, University of Heidelberg
Sabine Engelmann, PhD (2006). Transgene Plasmodium berghei reporter parasites and their
application to study the biology of the malaria parasite. University of Heidelberg.
Current Occupation: Assistant Researcher, European Commission, Brussels.
Ahmed Aly, PhD (2005). Functional characterization of two novel malarial essential genes by
reverse genetics. University of Heidelberg.
Current Occupation: Postdoctoral Fellow, Seattle Biomedical Research Institute,
Seattle, U.S.A.
Ann-Kristin Müller, PhD (2004). Functional characterization of Plasmodium sporozoitespecific
genes in the rodent malaria model. University of Heidelberg.
Current Occupation: EMBO Fellow at London School of Tropical Medicine and
Hygiene.
Awards: MBL Award for participation at the course ‘Biology of Parasitism: Modern
Approaches’ (2002); Top student presentation’ at the XVI Molecular Parasitology
Meeting, Woods Hole (2005); Karl Freudenberg Award (2006); Award ‚Medizinische
Grundlagenforschung’ of the GlaxoSmithKline Foundation Germany (2006).