Prof. Dr. Bernhard Dobberstein Center for Molecular ... - HBIGS

Prof. Dr. Bernhard Dobberstein
Center for Molecular Biology Heidelberg (ZMBH)
University of Heidelberg
69120 Heidelberg, Germany
Phone: +49-(0)6221-54 6825
Fax: +49-(0)6221-54 5892
Email: b.dobberstein@zmbh.uni-heidelberg.de
10/07/1944, Quiram
CURRICULUM VITAE
2004 - present Member of the DFG Senate Commission for the approval of SFB Projects
2001 - 2002 Dean, Master Programme "Molecular and Cellular Biology"
1996 - 1997 Director of the ZMBH
1993 - present Professor for Molecular Biology at the Zentrum für Molekulare Biologie der
Universität Heidelberg (ZMBH), Heidelberg
1985 Habilitation, University of Heidelberg
1984 - 1992 Senior Scientist, EMBL, Heidelberg
1976 - 1984 Group leader, European Molecular Biology Laboratory (EMBL), Heidelberg
1974 - 1976 PostDoc, with Dr. Günter Blobel, Rockefeller University, New York, USA
1974 Ph.D. in Biology, (Bonn)
1967 - 1971 Biology studies (Bonn)
COORDINATING FUNCTIONS
2004 – present Member steering committee SFB638, University Heidelberg
2004 – present Coordinator of the Molecular Biology Program, Faculty of Biosciences
1996 - 2004 Spokesman of the DFG Gradiertenkolleg 230 "Molecular Cell Biology"
1996 - 1997 Coordinator of the University projects in the "BIOREGIO" competition
1993 - 1995 Coordinator of the Landesforschungsprojekt "Molekulare Zellbiologie"
1993 - 1996 Principal coordinator, EU Human Frontier Science Program "Protein
assembly and sorting in the endoplasmic reticulum"
1992 - 2003 Member steering committee SFB352, University Heidelberg
FIELDS OF INTEREST
Protein translocation across and membrane insertion into the membrane of the endoplasmic
reticulum; signal peptide functions beyond targeting; Posttranslational insertion of proteins
into the ER membrane.

CURRENTLY FUNDED PROJECTS
SFB 638: project A2: "Dynamik makromolekularer Komplexe im biosynthetischen Transport"
Graduiertenkolleg 1188: " Quantitative Analysis of Dynamic Processes in membrane
Transport and Translocation"
Current supervision of 5 doctoral theses
PUBLICATIONS (10 most important publications):
Römisch, K., Miller, F.W., Dobberstein, B. and High, S. 2006. Human autoantibodies against
the 54 kDa protein of the signal recognition particle block function at multiple stages.
Arthritis Research & Therapy 2006,8:R39 (doi:10.1186/ar1895)
Martoglio, B. and Dobberstein, B. 2005. Cotranslational translocation of proteins into
microsomes derived from the rough endoplasmic reticulum of mammalian cells. In: Cell
Biology, Ch. 30, Ed. Celis, J., 3rd ed.
Terzi, L., Pool, M.R., Dobberstein, B. and Strub, K. 2004. The signal recognition particle Alu
domain occupies a defined site at the ribosomal subunit interface upon signal sequence
recognition, Biochem. 43:107-117
Froeschke, M., Basler, M., Groettrup, M. and Dobberstein, B. 2003. Long-lived signal peptide
of lymphocytic choriomeningitis virus glycoprotein pGP-C. J. Biol. Chem. 278:41914-41920.
Pool, M.R., Stumm, J. Fulga, T.A., Sinning, I. and Dobberstein, B. 2002. Distinct modes of
signal recognition particle interaction with the ribosome. Science 297:1345-1348.
Fulga, T.A., Sinning, I., Dobberstein, B. and Pool, M.R. 2001. SRβ coordinates signal
sequence release from SRP with ribosome binding to the translocon. EMBO J. 20:2338-
2347.
Hölscher, C., Bach, U.C. and Dobberstein, B. 2001. Prion protein contains a second
endoplasmic reticulum targeting signal sequence located at its C-terminus. J. Biol. Chem.
276:13388-13394.

EXPERIENCE IN THE SUPERVISION OF DOCTORAL CANDIDATES
Member of numerous thesis and thesis advisory committees
International reviewer of doctoral theses
SUPERVISED DISSERTATIONS (last 5 years)
Milan Spasic, PhD (2005) Post-translational insertion of a small tail-anchored protein into the
membrane of the endoplasmic reticulum
Current occupation: Postdoctoral fellow, DKFZ
Anshuman Kelkar, PhD (2005) Functional analysis of Sec61beta, a component of the Sec61
protein translocation channel at the endoplasmic reticulum
Current occupation: Postdoctoral fellow, Rockefeller University
Christoph Jüschke, PhD (2005) Charakterisierung des Transportweges von Ist2p zur
Plasmamembran in Saccharomyces cerevisiae
Current occupation: Postdoctoral fellow, Institute of Molecular Biotechnology, Vienna
Steffen Frey, PhD (2002) Charakterisierung von Scp160p, einem mRNA- und
ribosomenassoziierten Protein in Saccharomyces cerevisiae
Current occupation: Postdoctoral fellow, ZMBH
Gerlinde Konrad, PhD (2002) Funktionelle Charakterisierung der Polyphosphoinositid
Phosphatase Sac1p in der Hefe Saccharomyces cerevisiae
Current occupation: unknown
Marc Fröschke, PhD (2001) Charakterisierung der Abspaltung und des Schicksals der
Signalsequenz des Glykoproteins des lymphozytären Choriomeningitis-Virus
Current occupation: unknown