Prof. Dr. Michael Lanzer Department of Parasitology ... - HBIGS

Prof. Dr. Michael Lanzer
Department of Parasitology
University of Heidelberg
69120 Heidelberg, Germany
Phone: +49-(0)6221-56 7845
Fax: +49-(0)6221-56 4643
E-mail: michael_lanzer@med.uni-heidelberg.de
13/09/1959, Düsseldorf
CURRICULUM VITAE
2000 Offer for Professorship at the Seattle Biomedical Institute, USA (declined)
1999 - present Full Professor and Head of Department of Parasitology, University of
Heidelberg
1996 Habilitation in Microbiology, University of Würzburg
1994 - 1998 Junior Group Leader, Research Center for Infectious Diseases, University
of Würzburg
1988 - 1993 Postdoc, Sloan-Kettering Institute, New York, USA.
1985 - 1988 PhD, Center for Molecular Biology, University of Heidelberg
1984 - 1985 Diploma Thesis, Hoffman LaRoche und Co. AG, Basel, Switzerland
1979 – 1984 Biology School, University of Heidelberg
COORDINATING FUNCTIONS
2005 – present Member of the Executive Committee of the Marie-Curie Fellowship
Program “MalParTraining”
2004 – present Member of the Executive Committee of the Network of Excellence
“BioMalPar”
2004 – present Member of the Executive Committee of the European Malaria Graduate
School
1999 – 2002 Co-chairman of the SFB 544 “Control of Tropical Infectious Diseases”
1993 – present Coordinator of various EU-funded research networks (6 in total)
HONORS
1995 Prize for Tropical Medicine, Awarded by the German Society for Tropical
Medicine
FIELDS OF INTEREST
Molecular Parasitology, drug resistance mechanisms of the malarial parasite; antigenic
variation, cytoadherence, protein trafficking in P. falciparum, membrane transport processes:

CURRENTLY FUNDED PROJECTS
SFB544, project B12; EU-funded Network of Excellence BIOMALPAR; EU-funded Integrated
Project AntiMal; EU-funded Marie Curie Fellowship Program MalParTraining; DFG-project on
protein trafficking in Plasmodium falciparum:
PUBLICATIONS (10 most important publications):
Sanchez CP, Rohrbach R, McLean JE, Fidock DA, Stein WD, Lanzer M (2007) Differences in
trans-stimulated chloroquine efflux kinetics are linked to PfCRT in Plasmodium falciparum.
Mol Micro in press
Rohrbach P, Sanchez CP, Hayton K, Friedrich O, Patel J, Sidhu AB, Ferdig MT, Fidock DA,
Lanzer M (2006) Genetic linkage of pfmdr1 with food vacuolar solute import in Plasmodium
falciparum. EMBO J 25: 3000-3011.
Przyborski JM, Miller SK, Pfahler JM, Henrich PP, Rohrbach P, Crabb BS, Lanzer M (2005)
Trafficking of STEVOR to the Maurer's clefts in Plasmodium falciparum-infected erythrocytes.
EMBO J 24: 2306-2317.
Rohrbach P, Friedrich O, Hentschel J, Plattner H, Fink RH, Lanzer M (2005) Quantitative
calcium measurements in subcellular compartments of Plasmodium falciparum-infected
erythrocytes. J Biol Chem 280: 27960-27969.
Nessler S, Friedrich O, Bakouh N, Fink RH, Sanchez CP, Planelles G, Lanzer M (2004)
Evidence for activation of endogenous transporters in Xenopus laevis oocytes expressing the
Plasmodium falciparum chloroquine resistance transporter, PfCRT. J Biol Chem 279: 39438-
39446.
Wissing F, Sanchez CP, Rohrbach P, Ricken S, Lanzer M (2002) Illumination of the malaria
parasite Plasmodium falciparum alters intracellular pH. Implications for live cell imaging. J
Biol Chem 277: 37747-37755.
del Portillo HA, Fernandez-Becerra C, Bowman S, Oliver K, Preuss M, Sanchez CP,
Schneider NK, Villalobos JM, Rajandream MA, Harris D, Pereira da Silva LH, Barrell B,
Lanzer M (2001) A superfamily of variant genes encoded in the subtelomeric region of
Plasmodium vivax. Nature 410: 839-842.
Scherf A, Hernandez-Rivas R, Buffet P, Bottius E, Benatar C, Pouvelle B, Gysin J, Lanzer M
(1998) Antigenic variation in malaria: in situ switching, relaxed and mutually exclusive
transcription of var genes during intra-erythrocytic development in Plasmodium falciparum.
EMBO J 17: 5418-5426.
Wunsch S, Sanchez CP, Gekle M, Grosse-Wortmann L, Wiesner J, Lanzer M (1998)
Differential stimulation of the Na+/H+ exchanger determines chloroquine uptake in
Plasmodium falciparum. J Cell Biol 140: 335-345.
Lanzer M, de Bruin D, Ravetch JV (1993) Transcriptional differences in polymorphic and
conserved domains of a complete cloned P. falciparum chromosome. Nature 361: 654-657.

EXPERIENCE IN THE SUPERVISION OF DOCTORAL CANDIDATES
Coordinator of and author of guidelines for the MD/PhD program at the University of
Heidelberg
Co-coordinator of the European Malaria Graduate School
Member of numerous thesis and thesis advisory committees
International reviewer of doctoral theses
Supervised 14 doctoral theses
SUPERVISED DISSERTATIONS (last 5 years)
Elise Schieck, PhD (2007) Analysis of var gene regulation in Plasmodium falciparum.
University of Heidelberg.
Current occupation: Postdoctoral fellow, University of Heidelberg.
Judith Pfahler, PhD (2006). Development of transfection systems for Plasmodium ssp. for
functional studies on gene regulation. University of Heidelberg
Current occupation: Research scientist at Geneart AG, Regensburg.
Armand Guiguemdé, PhD (2005) Functional characterization of a putative Plasmodium
falciparum calcium/hydrogen antiporter pfcha. University of Heidelberg.
Current occupation: Postdoctoral fellow, St. Jude Children’s Research Hospital,
Memphis, USA.
Weidong Zhu, PhD (2004) Identification of novel proteins on the surface of Plasmodium
falciparum infected erythrocytes. University of Heidelberg.
Current occupation: Postdoctoral fellow, Los Angeles Biomedical Research Institute,
Torrance, USA
Susanne Nessler, PhD (2004) Funktional analysis of the P. falciparum chloroquin resistancedeterminant
PfCRT in Xenopus laevis oocytes. University of Heidelberg.
Current occupation: Highschool teacher.
Jude Przyborski, PhD (2004) Trafficking of STEVOR to the Maurer’s clefts in Plasmodium
falciparum-infected erythrocytes. University of Heidelberg.
Current occupation: Research group leader, University of Marburg.
Inas Zakaria Ahmed, MD (2004) Molecular assessment of malaria infections in a rural area in
Burkina Faso. University of Heidelberg.
Current occupation: Assistant lecturer, University of Kairo.
Hannes Wickert, MD/PhD (2003) Analysis of transport pathways in the red blood cell infected
by the human malaria parasite P. falciparum. University of Würzburg
Current occupation: Clinical research fellow, University Hospital of Cleveland, USA.
Nicola Viebig, PhD (2003) Activation of endothelial cells by Plasmodium falciparum-infected
erythrocytes and characterization of putative adhesion receptors. University of
Heidelberg.
Current occupation: Postdoctoral fellow, Institute Pasteur, France.
Viktoria Baur, MD (2003) Antigenic variation in Plasmodium vivax. University of Heidelberg.
Current occupation: Interim physician: University of Heidelberg.

Martin Preuß, PhD (2002) Genetic analysis of antigenic variation in the human malarial
parasites Plasmodium falciparum and Plasmodium vivax. University of Heidelberg.
Current occupation: Scientific officer, Water Surveillance Institute, Schweinfurt.