Dr. Stephan Herzig Emmy-Noether and Marie Curie ... - HBIGS

Dr. Stephan Herzig
Emmy-Noether and Marie Curie Research Group
Molecular Metabolic Control
German Cancer Research Center Heidelberg (DKFZ)
69120 Heidelberg, Germany
Phone: +49-(0)6221-42 3594
Fax: +49-(0)6221-42 3595
E-mail: s.herzig@dkfz.de
13/10/1969, Bremen
CURRICULUM VITAE
2003 - present Emmy Noether and Marie Curie Group Leader, German Cancer Research
Center (DKFZ) Heidelberg
2000 – 2003 PostDoc, Salk Institute for Biological Studies, La Jolla, CA, USA.
1996 – 1999 PhD, Dept. Molecular Pharmacology, University of Göttingen
1996 1 st Federal Exam in Biology and Geography, University of Göttingen
1990 – 1996 Biology and Geography School, University of Göttingen
COORDINATING FUNCTIONS
2006 – present Permanent Jury Member, DKFZ International PhD Program
2003 - present Member of Department Head and Group Leader Conference of the
Research Program A “Cell and Tumor Biology”, DKFZ Heidelberg
2003 – present Member of the Scientific Director’s Conference, DKFZ Heidelberg
FIELDS OF INTEREST
Molecular Endocrinology; metabolic diseases; transcriptional control mechanisms; signal
transduction
CURRENTLY FUNDED PROJECTS
DFG-Emmy Noether Program (He3260/2-1); EU-Marie Curie Excellence Grant (“Insulin
Resistance”); DFG-project (He3260/3-1); European Foundation for the Study of Diabetes-
Johnson&Johnson Grant; European Foundation for the Study of Diabetes-NovoNordisk
Grant; Novartis Foundation for Therapeutic Research-Research Award; Thyssen Foundation-
Research Grant

PUBLICATIONS (10 most important publications):
Vegiopoulos A, Herzig S (2007) Glucocorticoids, metabolism and metabolic diseases. Mol
Cell Endocrinol In revision
Berriel Diaz M, Lemke U, Herzig S (2006) Discovering orphans’ sweet secret: NR4A
receptors and glucose production. Cell Metab 4: 339-340.
Krones-Herzig A, Mesaros A, Metzger D, Ziegler A, Lemke U, Brüning JC, Herzig S (2006)
Signal-dependent control of gluconeogenic key enzyme genes through co-activator
associated methyltransferase 1. J Biol Chem 281: 3025-3029.
Dimova E, Möller U, Herzig S, Fink T, Zachar V, Ebbesen P, Kietzmann T (2005)
Transcriptional regulation of Plasminogen Activator Inhibitor-1 expression by Insulin-
Like Growth Factor-1 via MAP kinases and Hypoxia-Inducible Factor –1 in HepG2
cells. Thromb Haemost 93: 1176-1184.
Koo SH, Satoh H, Herzig S, Lee CH, Hedrick S, Kulkarni R, Evans RM, Olefsky J, Montminy
M (2004) PGC-1 promotes insulin resistance in liver via the PPARα dependent
induction of TRB3. Nat Med 10: 530-534.
Herzig S, Hedrick S, Morantte I, Koo SH, Galimi F, Montminy M (2003) CREB controls
hepatic lipid metabolism through nuclear hormone receptor PPARγ. Nature 426: 190-
193.
Herzig S*, Du K*, Kulkarni R, Montminy M (2003) TRB-3: a tribbles homolog that inhibits
Akt/PKB activation by insulin in liver. Science 300: 1574-1577. (*Authors contributed
equally to this work.)
Canettieri G, Morantte I, Guzman E, Asahara H, Herzig S, Anderson SD, Yates III JR,
Montminy M (2003) Attenuation of a phosphorylation dependent activator by an
HDAC:PP1 complex. Nat Struc Biol 10: 175-181.
Herzig S, Long F, Jhala US, Hedrick S, Quinn R, Bauer A, Rudolph D, Schütz G, Yoon C,
Puigserver P, Spiegelman B, Montminy M (2001) CREB regulates hepatic
gluconeogenesis through the coactivator PGC-1. Nature 413: 179-183.
Herzig S, Füzesi L, Knepel W (2000) Heterodimeric Pbx-Prep1 homeodomain protein binding
to the glucagon gene restricting transcription in a cell type-dependent manner. J Biol
Chem 275: 27989-27999.

EXPERIENCE IN THE SUPERVISION OF DOCTORAL CANDIDATES
Permanent member of jury and review board, International PhD program of the DKFZ
Member of numerous thesis and thesis advisory committees
Supervised/supervising 6 doctoral theses
SUPERVISED DISSERTATIONS (last 5 years)
None yet