Department of Biomolecular Mechanims Max Planck ... - HBIGS

Dr. Anton Meinhart
Department of Biomolecular Mechanims
Max Planck Institute for Medical Research
69120 Heidelberg, Germany
Phone: +49-(0)6221-486 505
Fax: +49-(0)6221-486 585
E-mail: Anton.Meinhart@mpimf-heidelberg.mpg.de
28/04/1974, Wels
CURRICULUM VITAE
2006 - present Research group leader, Max Planck Institute for Medical Research,
Heidelberg
2004 - 2006 Project leader, Max Planck Institute for Medical Research, Heidelberg
2002 - 2004 Postdoc, Gene Center, University of Munich
2001 - 2002 Postdoc, Free University of Berlin
1999 - 2001 Ph.D., Free University of Berlin
1997 – 1998 Diploma thesis, Crystallography, University of Vienna, Austria and
University of Cologne
1993 – 1997 Study of Mineralogy and Crystallography, University of Vienna, Austria
HONORS AND FELLOWSHIPS
2003 - 2004 EMBO long term fellowship
1999 Young Scientist Award from the Faculty of Natural Science,
University of Vienna
1997 - 1998 DAAD-Fellowship, Student exchange program
FIELDS OF INTEREST
Structure – Function relationship of RNA processing factors; Coupling of Processing
machines in RNA maturation; Bacterial Toxin Antitoxin systems
CURRENTLY FUNDED PROJECTS
DFG Einzelantrag ME 3135/1-2

PUBLICATIONS (10 most important publications):
Vasiljeva, L., Kim, M., Mutschler, H., Buratowski, S., and Meinhart, A. (2008). The Nrd1-
Nab3-Sen1 termination complex interacts with the Ser5-phosphorylated RNA polymerase II
C-terminal domain. Nat. Struct. Mol. Biol. 15:795-804.
Becker, R., Loll, B., and Meinhart, A. (2008). Snapshots of the RNA processing factor SCAF8
bound to different phosphorylated forms of the carboxy-terminal domain of RNA-polymerase
II. J. Biol. Chem. 283:22659-22669.
Khoo, S. K., Loll, B., Chan, W. T., Shoeman, R. L., Ngoo, L., Yeo, C. C., and Meinhart, A.
(2007). Molecular and structural characterization of the PezAT chromosomal toxin-antitoxin
system of the human pathogen Streptococcus pneumoniae. J. Biol. Chem. 282:19606-
19618.
Meinhart, A., Kamenski, T., Hoeppner, S., Baumli, S., and Cramer, P. (2005). A structural
perspective of CTD function. Genes Dev. 19:1401-1415.
Armache, K. J., Mitterweger, S., Meinhart, A., and Cramer, P. (2005). Structures of complete
RNA polymerase II and its subcomplex, Rpb4/7. J. Biol. Chem. 280:7131-7134.
Kamenski, T., Heilmeier, S., Meinhart, A., and Cramer, P. (2004). Structure and mechanism
of RNA polymerase II CTD phosphatases. Mol. Cell 15:399-407.
Meinhart, A., and Cramer, P. (2004). Recognition of RNA polymerase II carboxy-terminal
domain by 3'-RNA-processing factors. Nature 430:223-226.
Meinhart, A., Silberzahn, T., and Cramer, P. (2003). The mRNA transcription/processing
factor Ssu72 is a potential tyrosine phosphatase. J. Biol. Chem. 278:15917-15921.
Meinhart, A., Blobel, J., and Cramer, P. (2003). An extended winged helix domain in general
transcription factor E/IIE alpha. J. Biol. Chem. 278:48267-48274.
Meinhart, A., Alonso, J. C., Strater, N., and Saenger, W. (2003). Crystal structure of the
plasmid maintenance system epsilon/zeta: functional mechanism of toxin zeta and
inactivation by epsilon 2 zeta 2 complex formation. Proc. Natl. Acad. Sci. USA 100:1661-
1666.
SUPERVISED DISSERTATION
Roland Becker PhD (2009) Revealing the interactions of RNA polymerase II binding proteins
– Characterization of CTD-interacting domains, University of Heidelberg.
Current occupation: Postdoctoral fellow, Max Planck Institute for Medical Research.