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Mechanisms in hydrocephalus revealed by neuroimaging

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How is Compliance Measured Invasively?<br />

•Marmarou et. al. J. Neurosurg, 1975<br />

Compliance = dV/dP<br />

Apparent Compliance = DV/(Pp-Po)<br />

DV <strong>in</strong> the order of several mL is used to overcome pressure pulsation<br />

MRICP is the non<strong>in</strong>vasive analogous of the volume-pressure response<br />

method, except that it does not <strong>in</strong>terfere with the craniosp<strong>in</strong>al hydrodynamics.<br />

MRICP measures the naturally occurr<strong>in</strong>g dV and dP with each heart beat.<br />

Credit: Noam Alper<strong>in</strong>, U. of Miami

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