Mechanisms in hydrocephalus revealed by neuroimaging

More documents

Recommendations

Info

Advanced imaging techniques insight into function and structure/function relationships • CSF flow • Compliance • Blood flow • White matter integrity • Metabolism • Brain function/connectivity
CSF flow Techniques • Cine phase contrast MRI • Quantitative measures SV, flow rate, peak velocity, … wide variability, technique/machine dependent !! Mechanisms • “Redistribution” • Increased brain pulsatility • Capillary pulsatility (pulse wave encephalopathy – ala Greitz) • Intracranial compliance
Page 1 and 2: Neuroimaging approaches for elucida
Page 3: Neurology. 2012 Jul 3. [Epub ahead
Page 7 and 8: There is abundant literature on the
Page 9 and 10: Toward mechanisms - Relationship be
Page 11 and 12: Changes Is there a in relationship
Page 13 and 14: Possible confounds - Physiological
Page 15 and 16: 4D phase contrast imaging - but wha
Page 17 and 18: time Real-time CSF flow during phys
Page 19 and 20: How is Compliance Measured Invasive
Page 21 and 22: The Physiologic Basis of MR-ICP IC
Page 23 and 24: How is dP Measured? • The pressur
Page 25 and 26: MR Elastography Freimann et al, Neu
Page 27 and 28: … but no change in compliance wit
Page 29 and 30: CBF Techniques - 133 Xe-CT - 15 O
Page 31 and 32: CBF by PET (NPH) CBF decreased, glo
Page 33 and 34: CBF by PCMRI • Increased with shu
Page 35 and 36: CBF by SPECT CBF marginally changed
Page 37 and 38: Diffusion Techniques • MRI - Dif
Page 39 and 40: Why would diffusion NOT be isotropi
Page 41 and 42: First demonstration of DTI changes
Page 43 and 44: ↓ FA increased, ↑MD in iNPH not
Page 45 and 46: FA/MD in corticospinal tract Correl
Page 47 and 48: Increased FA in caudate … improve
Page 49 and 50: Liliefeld et al, JNSPeds 2009
Page 51 and 52: Functional MRI ???
Page 53: Acknowledgements Pat McAllister, Ph

Mechanisms in hydrocephalus revealed by neuroimaging

Create successful ePaper yourself

Delete template?

Save as template?