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6 | ISSUE N°139 | 7/02/13 MEMS SiTime expands portfolio with +125C MEMS oscillators for industrial and high reliability applications Best robustness and reliability are ideal for harsh environments; best stability and power consumption improve system performance. ZOOM Bosch designs Application-Specific Integrated Circuits for MEMS sensors in Dresden Focus on automotive and consumer applications. SiTime introduced the SiT8920 MEMS oscillator for industrial and high reliability applications. Due to its unique silicon MEMS and analog architecture, the SiT8920 outperforms quartz oscillators in every major performance category. While operating over the widest temperature range, -55°C to +125°C, the SiT8920 consumes half the power of quartz oscillators, is twice as stable, 20 times more reliable and 30 times more robust to shock and vibration. These key benefits dramatically improve system performance and reduce failures in harsh environments. «SiT8920“SiTime’s MEMS and analog expertise allows us to deliver unique, leadership products with performance that is far beyond what is available in the market,” said Piyush Sevalia, executive vice president of marketing at SiTime. “The SiT8920 is a win-win for customers developing industrial and highreliability applications. They benefit from dramatically better robustness and reliability, while simultaneously improving system performance. SiTime’s MEMS oscillators incorporate unique features that are simply not available from quartz products. For example, the SiT8920 incorporates SiTime’s unique SoftEdge rise/fall time control that reduces system EMI without additional components, expensive shielding or PCB re-design. By offering such compelling benefits, SiTime is transforming the timing industry with its silicon MEMS solutions.” SiTime is also introducing two additional devices that are well suited for replacing quartz oscillators and crystal resonators. • SiT1618 – a fixed-frequency oscillator that operates over -40°C to +125°C • SiT8918 – a programmable oscillator that operates over the same temperature range and supports any frequency between 1 and 110 MHz as well as 1.8V and 2.5 to 3.3V operation These new high-temp oscillators offer many unique features and benefits listed below. • Best robustness: 30 times better than quartz oscillators - 0.1 ppb/g vibration sensitivity, the best in the industry - 50,000 g shock and 70 g vibration resistance • Best reliability: 500 million hours MTBF (2 FIT), 20 times better than quartz oscillators • Best frequency stability: ±25 PPM over the operating temperature for better system timing • Low power consumption: < 4 mA typical • Five industry-standard package options including a tiny 2.0 x 1.6 mm, all of which are drop-in replacements for quartz oscillators • The SiT8920, SiT8918 and the SiT1618 MEMS oscillators are sampling now with mass production scheduled for April 2013. www.sitime.com Bosch has started its ASICs (Application- Specific Integrated Circuits) design activities for MEMS sensors in Dresden, Germany. These sensors are silicon-based and sense for instance motions, pressure or magnetic fields. MEMS sensors are to be used in a variety of automotive applications such as motor controls, vehicle dynamics controls and rollover detection – more and more in consumer electronics applications such as smart phones, games consoles or tablets as well. The related ASIC reads out the sensor and transmits the metered value in analog or digital mode. The correspondent design of the circuit allows reliable and secure figures of merit to be required for applications such as in smart phones or cars. Bosch sees a huge growth potential in the market for MEMS sensors and related ASICs (Application Specific ICs). The new Dresden design center expands the company’s existing network of IC design locations in Reutlingen, Munich, Shanghai and Bangalore. With its local presence in Dresden as one of Europe’s most dynamic microelectronics industrial centers, Bosch also gets access to the great academic and engineering potential in the Dresden area. «Besides our profound expertise in MEMS technology, excellent IC developers are essential factors for the expansion of our innovative product portfolio,» says Udo- Martin Gomez , CTO of Bosch Sensortec GmbH. «At the same time, this move reflects Bosch’s commitment to Germany as semiconductor development and manufacturing location,» says Erich Biermann, Senior Vice President Engineering at Bosch Semiconductors. www.bosch.com IDT announces industry’s first high-performance quad frequency MEMS oscillators with multiple synchronous outputs IDT’s enhanced 4E MEMS oscillators offer configurable outputs in an industry-standard package footprint, saving board area in communication, networking, and storage applications. Integrated Device Technology (IDT ® ) announced the industry’s first highperformance quad frequency MEMS oscillators with multiple synchronous outputs. IDT’s latest oscillators offer configurable outputs in an industry-standard compatible package footprint, saving board area and bill-of-materials (BOM) cost in communication, networking, storage, industrial, and FPGA applications. The IDT 4E series ±50 ppm enhanced MEMS oscillators integrate an LVDS or LVPECL output with a synchronous CMOS output into a single package, eliminating the need for an external crystal or secondary oscillator. Available in frequencies up to 600 MHz, the new oscillators save board area, simplify the application circuit, and reduce BOM cost in any high-performance application requiring an LVDS or LVPECL frequency source. Additionally, the oscillators feature two control pins to select between four factoryprogrammable output frequencies, allowing for the replacement of four components with a single device. This enables the customer to reduce their BOM count, consolidate their inventory, and realize cost benefits. “Our new CrystalFree MEMS oscillators eliminate the need for additional quartz crystals and bring tremendous value to our customers,” said Christian Kermarrec, vice president and general manager of the timing and synchronization division at IDT. “Our new 4E series provides our customers with what they’ve been asking for – simplicity and cost savings. Not only have we met these demands, we’ve also maintained backward compatibility with their existing socket footprints to ease the transition to these new devices.” The IDT 4E series oscillators are designed with the physical dimensions and pinout of an industry-standard six-pin CMOS, LVDS or LVPECL oscillator, but with four additional pins (10 pins total) strategically placed to maintain backward compatibility with existing six-pin sockets. This allows designers to use the oscillators in existing sockets while offering additional functionality for new designs. Prepare yourself for 2013 funding opportunities! System designers can choose from three different output combinations: LVDS and CMOS outputs, LVPECL and CMOS outputs, or three synchronous CMOS outputs – offering the flexibility to use the innovative devices in a myriad of applications. Would you like to benefit from interesting programmes and offers to finance your advanced technology projects? By participating in this webcast tutorial, you’ll gain valuable insights into: Join the online tutorial on 14 th February - 1:00 PM CET* The IDT 4E MEMS oscillators are currently sampling to qualified customers and are available in a standard 7.0 x 5.0 mm VFQFPN package. www.idt.com Tutorial Webcast Speakers: Moderator: To register or get more information: Organised by: Hosted by:
7/02/13 | ISSUE N°139 | 7 MEDTECH Akonni pre-clinical results on rapid, low-cost array moves company closer to commercialization for its infectious disease test portfolio Data demonstrate that the TruDiagnosis ® platform is ready for expanded, multi-site clinical trials. Akonni Biosystems announces results from three pre-clinical studies that contribute to the body of clinical evidence that verifies the efficacy of Akonni’s TruDiagnosis molecular diagnostics (MDx) platform. Akonni TruArray ® Tests are designed to fulfill market needs for mid-multiplex molecular diagnostics (tens to hundreds of molecular markers) deployed in near point-ofcare settings, at a similar cost to conventional culture tests and with the accuracy and speed of gold-standard low-multiplex approaches. These studies, including those for methicillinresistant Staphylococcus aureus (MRSA), multi-drug resistant Mycobacterium tuberculosis (MDR-TB), and influenza subtyping, were funded and developed over the past six years by carefully leveraging more than $45M in private and public funding from the National Institutes of Health (NIH), Centers for Disease Control (CDC), National Science Foundation (NSF), and the Department of Defense (DOD). Well positioned to take advantage of a $3.0B plus market The aggregate market opportunity for infectious disease diagnostics exceeds $3B in the United States alone, according to an October, 2012 report by Cowen & Company, LLC. Akonni’s TruDiagnosis platform is positioned to exploit this and broader global health markets with its unique TruArray Tests, which are designed to significantly reduce the complexity and cost of traditional midmultiplex microarray consumables, equipment, and workflows for laboratory technicians. Mid-level multiplexed molecular assays that can be deployed in the field or in lower-resource settings are particularly useful for infectious disease diagnostics, detecting drug resistance markers, and improving the health of at-risk populations. Streamlined chemistry simplifies workflow compared to other microarray platforms Relative to the microarray products provided by Affymetrix (AFFX), Agilent (A), Combimatrix (CBMX), and by Luminex (LMNX), Akonni’s TruArray tests significantly simplify microarray workflows by combining conventional target amplification, fragmentation and labeling processes into a single tube or microfluidic chamber. Preliminary studies also indicate that all amplification, labeling, hybridization, and wash steps can be combined into a single, selfcontained amplification microarray consumable, resulting in an entirely closedamplicon microarray-based test. Each drop is an individual biosensor Each drop is 100 microns in diameter Each drop can indentify a unique disease marker TruArray technology (Courtesy of Akonni) Methicillin-resistant Staphylococcus aureus program In collaboration with researchers from Johns Hopkins University, Akonni conducted a retrospective study on 87 clinical isolates and 246 nasal swab samples acquired from a nonrandom, high-risk patient population. Of the 87 isolates, the TruArray test accurately classified 86 (98.8%) and correctly identified 14 mecA dropout specimens that were falsely positive in the BD GeneOhm MRSA or BD GeneOhm StaphSR tests. The overall prevalence of MRSA in the clinical sample set was 16.7%. The TruArray test resulted in 80.5% sensitivity and 96.6% specificity, comparable to or better than Cepheid Xpert MRSA or BD GeneOhm tests when applied to similar, high-prevalence patient populations containing a significant number of mecA dropouts. This study was published in 2012 in the Journal of Microbiological Methods. MDR-TB program In collaboration with researchers from Johns Hopkins University, Akonni conducted a study with 185 Mycobacterium tuberculosis isolates representing a world-wide distribution of rifampin, isoniazid, streptomycin and ethambutol resistance genotypes. The simplified TruArray Test containing 96 unique probes for 39 drug-resistant mutations in 5 genes enabled a single technician to run up to 24 samples in under 6 hrs using an industry standard thermal cycler and a field-portable, low cost microarray imager. Of 196 mutations in the culture set that were also represented on the microarray, the TruArray test correctly detected 193 (98.4% success rate). This study is scheduled to be submitted for publication in the first quarter of 2013. Influenza subtyping program In collaboration with the United States Centers for Disease Control (CDC), New York Department of Health’s Wadsworth Center, and Little Company of Mary Hospital (Chicago), Akonni developed a simplified TruArray Test for influenza detection, sub-typing, and neuramidase resistance detection from nasopharyngeal swabs (in viral transport medium). Limits of detection in clinical nasopharyngeal swab samples were approximately 100 RNA gene copies per test, regardless of influenza subtype. The most sensitive probes were those targeting seasonal and pandemic influenza A H275Y variants. Using a CDC surveillance and reporting guideline, definitive identification was provided for 164 of 178 samples (92%) and 328 of 342 hybridizations (95.9%). No false positives were detected. www.akonni.com Quick detection of periodontitis pathogens based on lab-on-chip technology A new diagnostic platform enables the pathogens to be detected quickly, enabling dentists to act swiftly to initiate the right treatment. Bleeding gums during tooth brushing or when biting into an apple could be an indication of periodontitis, an inflammatory disease of the t<strong>issue</strong>s that surround and support the teeth. Bacterial plaque attacks the bone, meaning teeth can loosen over time and in the worst case even fall out, as they are left without a solid foundation to hold them in place. Furthermore, periodontitis also acts as a focal point from which disease can spread throughout the entire body: If the bacteria, which can be very aggressive, enter the bloodstream, they can cause further damage elsewhere. Physicians suspect there is a connection between periodontitis pathogens and the sort of cardiovascular damage that can cause heart attacks or strokes. In order to stop the source of inflammation, dentists remove dental calculus and deposits from the surface of teeth, but this is often not enough; particularly aggressive bacteria can only be eliminated with antibiotics. A new mobile diagnostic platform is designed to speed up identification of the eleven most relevant periodontitis pathogens considerably. Scientists at the Fraunhofer Institute for Cell Therapy and Immunology IZI in Leipzig have collaborated with two companies, BECIT GmbH and ERT- Optik, to develop a lab-on-a-chip module called ParoChip. In future this will allow dentists and medical labs to prepare samples quickly and then analyze the bacteria. All the steps in the process – the duplication of DNA sequences and their detection – take place directly on the platform, which consists of a disk-shaped microfluidic card that is around six centimeters in diameter. To read the complete article, please visit Fraunhofer website. www.fraunhofer.de 5-6 March 2013 Barcelona, Spain AGENDA TOPICS Diagnostics and Medical Applications Droplet-Based Microfluidics Market Orientated Device Nanotech on a Chip Optofluidics Point of Care Devices and Diagnostics Single Cell Analysis REGISTER NOW Industry Delegate €1199 Academic Delegate €699 Pre Doctoral Full Time Student €299 2for1 Passes Register now and get a second delegate pass for free! Register now at SelectBio.com/LOACEC2013 CALL FOR POSTERS Deadline: 19 February 2013 You can present your research on a poster while attending the meeting. Submit an abstract for consideration now! For large groups or to discuss specific requirements, please contact us: Email: registrations@selectbio.com Phone: +44 (0) 1787 315115 web: www.selectbio.com Event Co-located with : Advances in Biodetection & Biosensors, Single Cell Analysis and Advances in Microarray Technology BioMEMS and microsensors are reshaping healthcare applications BioMEMS E enquiries@selectbio.com P +44 (0)1787 315110 Woodview, Bull Lane, SUDBURY, CO10 0FD, UK SelectBio.com Discover the NEW report on i-<strong>Micronews</strong>.com/reports
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Page 9 and 10: 7/02/13 | ISSUE N°139 | 9 LED UGA
Page 11 and 12: 7/02/13 | ISSUE N°139 | 11 OPTOELE
Page 13 and 14: 7/02/13 | ISSUE N°139 | 13 ADVANCE
Page 15: 7/02/13 | ISSUE N°139 | 15 TECHNOL

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