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Bone mineralisation during osteoporosis

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European Research Council Investigator Award<br />

Fergal O‘Brien (2010- 2014)<br />

• Role of biophysical stimuli in regulating MSC<br />

differentiation<br />

- computational predictions of optimal flow<br />

conditions<br />

- applied to experimental models of:<br />

- osteogenesis<br />

- angiogenesis<br />

• Scaffold as delivery systems for bone formation<br />

- cells<br />

- tissue<br />

- genes (non-viral technologies)<br />

- growth factors (sustained release)

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