Bone mineralisation during osteoporosis
Bone mineralisation during osteoporosis
Bone mineralisation during osteoporosis
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Examined<br />
12<br />
Months<br />
31 Months Zoledronic Acid<br />
<strong>Bone</strong> Mineral Density - - -<br />
Architecture ↓ ↓ ↑<br />
Microstructure ↓ ↓ No data<br />
Mineralisation ↓ ↓ ↑<br />
Microdamage - ↑ ↑<br />
<strong>Bone</strong> Turnover ↑ ↑ ↓<br />
Osteocyte Apoptosis ↑ ↑ ↓<br />
Strength<br />
Material ↓ ↓ ↑<br />
Unit ↑ ↑ No data<br />
Specimen ↓ ↓ ↑<br />
Whole <strong>Bone</strong> ↓ ↓ No Data<br />
Brennan et al, J Orthop Res<br />
(In Press).<br />
Brennan et al, J Biomech (In<br />
Press).<br />
Healy et al, J Orthop Res<br />
2010.<br />
Brennan et al, J Biomech,<br />
2009.<br />
Kennedy et al, J Anat 2009.<br />
Keeley et al, Vet Comp<br />
Orthop Traumatol 2008,.<br />
Kennedy et al, Spine. 2008.<br />
Kennedy et al, J Orthop Res<br />
2008.<br />
Kennedy et al, <strong>Bone</strong>. 2008.<br />
Kennedy et al, Stud Health<br />
Technol Inform. 2008.<br />
DEXA does not adequately predict fracture risk in an ovine <strong>osteoporosis</strong> model<br />
Collaborators: RCSI, UCD, TCD, NUIG, Olin College, University of Adelaide
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