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Abbreviated Interrupted Time-Series - Institute for Policy Research

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Potential drawbacks of using HLM to analyze<br />

and synthesize SCD data (both within and<br />

across studies):<br />

1. Can be intimidating to some researchers<br />

2. Can be difficult to estimate parameters when models<br />

get complex<br />

• Especially when number of time points and<br />

number of cases is small.<br />

• Especially when modeling quadratic terms.<br />

• Especially when using a fully random effects<br />

model.<br />

92

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