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The neurotoxic cascade in the ischemic penumbra

The neurotoxic cascade in the ischemic penumbra

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T imag<strong>in</strong>g of hypoxic cells by down-regulated receptors<br />

adenos<strong>in</strong>e A(1) receptors<br />

Tadashi et al., J Nucl Med 20<br />

• [1-methyl-( 11 )C]8-dicyclopropylmethyl-1-methyl-3-propylxanth<strong>in</strong>e (MPD<br />

•<br />

18<br />

F-CPFPX (8-cyclopentyl-3-(3 fluoropropyl)-1-propylxanth<strong>in</strong>e)<br />

-CPFPX<br />

Degree of decrease<br />

<strong>in</strong> A1R ligand b<strong>in</strong>d<strong>in</strong>g is a sensitive<br />

predictor of severe <strong>ischemic</strong> <strong>in</strong>sult<br />

Transient MCAO <strong>in</strong> cats

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