The neurotoxic cascade in the ischemic penumbra
The neurotoxic cascade in the ischemic penumbra
The neurotoxic cascade in the ischemic penumbra
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T imag<strong>in</strong>g of hypoxic cells by down-regulated receptors<br />
adenos<strong>in</strong>e A(1) receptors<br />
Tadashi et al., J Nucl Med 20<br />
• [1-methyl-( 11 )C]8-dicyclopropylmethyl-1-methyl-3-propylxanth<strong>in</strong>e (MPD<br />
•<br />
18<br />
F-CPFPX (8-cyclopentyl-3-(3 fluoropropyl)-1-propylxanth<strong>in</strong>e)<br />
-CPFPX<br />
Degree of decrease<br />
<strong>in</strong> A1R ligand b<strong>in</strong>d<strong>in</strong>g is a sensitive<br />
predictor of severe <strong>ischemic</strong> <strong>in</strong>sult<br />
Transient MCAO <strong>in</strong> cats