The neurotoxic cascade in the ischemic penumbra
The neurotoxic cascade in the ischemic penumbra
The neurotoxic cascade in the ischemic penumbra
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T imag<strong>in</strong>g of free radical-<strong>in</strong>duced necrosis<br />
11<br />
C-PJ34 : phenanthrid<strong>in</strong>one derivative which<br />
b<strong>in</strong>ds to PARP<br />
PARP-1 is up-regulated dur<strong>in</strong>g cell necrosis<br />
streptozotoc<strong>in</strong>-<strong>in</strong>duced pancreas necrosis<br />
Control<br />
No sta<strong>in</strong><strong>in</strong>g was observed <strong>in</strong> control rats.<br />
STZ treated<br />
Accumulation of 11 C-PJ34 is shown <strong>in</strong> STZtreated<br />
rats as dark brown sta<strong>in</strong><strong>in</strong>g localized<br />
<strong>in</strong> <strong>the</strong> nuclei of islets <strong>in</strong> <strong>the</strong> rat pancreas
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