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4-Aminopiperidine Building Blocks - Dottikon

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4-<strong>Aminopiperidine</strong> <strong>Building</strong> <strong>Blocks</strong><br />

Core Hydrogenation to N-Substituted 4-<strong>Aminopiperidine</strong> <strong>Building</strong> <strong>Blocks</strong><br />

Typical building blocks<br />

Benzyl-<br />

NH2<br />

N<br />

R<br />

DOTTIKON ES, with its production site in <strong>Dottikon</strong> (Aargau, Switzerland), is specialized in hazardous chemical reactions and focuses on the exclusive synthesis of fine<br />

chemicals for the pharmaceutical and chemical industry worldwide. The product range of DOTTIKON ES includes active pharmaceutical ingredients (APIs) and<br />

pharmaceutical intermediates as well as in-house-developed, high-value industrial chemicals.<br />

Contact<br />

Europe<br />

<strong>Dottikon</strong> Exclusive Synthesis AG<br />

P.O. Box, 5605 <strong>Dottikon</strong>, Switzerland<br />

Tel +41 56 616 81 11, Fax +41 56 616 81 20<br />

info@dottikon.com, www.dottikon.com<br />

Methoxyethyl-<br />

O<br />

NH2<br />

N<br />

United States of America<br />

<strong>Dottikon</strong> ES America, Inc.<br />

803 W. Trenton Avenue, Suite 1, Morrisville, PA 19067, USA<br />

Tel +1 215 295 2295, Fax +1 215 295 2577<br />

info.us@dottikon.com, www.dottikon.com<br />

Methoxypropyl-<br />

O<br />

NH2<br />

N<br />

Alkoxycarbonyl-<br />

O<br />

NH2<br />

N<br />

OAlkyl<br />

� Combination of<br />

DOTTIKON's<br />

core technologies<br />

� High-pressure<br />

� Hazardous<br />

Reactions<br />

� Multi-ton production<br />

facilities<br />

� Tailor-made<br />

4-aminopiperidines<br />

on request


4-<strong>Aminopiperidine</strong> <strong>Building</strong> <strong>Blocks</strong> for API Structures<br />

Illustrative Examples of Potential use in Patent-Protected Structures<br />

R<br />

R<br />

X<br />

X<br />

R<br />

DOTTIKON ES, with its production site in <strong>Dottikon</strong> (Aargau, Switzerland), is specialized in hazardous chemical reactions and focuses on the exclusive synthesis of fine<br />

chemicals for the pharmaceutical and chemical industry worldwide. The product range of DOTTIKON ES includes active pharmaceutical ingredients (APIs) and<br />

pharmaceutical intermediates as well as in-house-developed, high-value industrial chemicals.<br />

Contact<br />

Europe<br />

<strong>Dottikon</strong> Exclusive Synthesis AG<br />

P.O. Box, 5605 <strong>Dottikon</strong>, Switzerland<br />

Tel +41 56 616 81 11, Fax +41 56 616 81 20<br />

info@dottikon.com, www.dottikon.com<br />

O<br />

N<br />

H<br />

R<br />

H<br />

N<br />

N<br />

O<br />

O N O<br />

United States of America<br />

<strong>Dottikon</strong> ES America, Inc.<br />

803 W. Trenton Avenue, Suite 1, Morrisville, PA 19067, USA<br />

Tel +1 215 295 2295, Fax +1 215 295 2577<br />

info.us@dottikon.com, www.dottikon.com<br />

NH 2<br />

N<br />

R<br />

X<br />

R R<br />

R<br />

R H<br />

R R<br />

N<br />

H<br />

H<br />

N<br />

O N<br />

N<br />

O<br />

OAlkyl<br />

R

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