Dottisol® â Solubility Enhancer - Dottikon
Dottisol® â Solubility Enhancer - Dottikon
Dottisol® â Solubility Enhancer - Dottikon
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Dottisol ® – <strong>Solubility</strong> <strong>Enhancer</strong><br />
Dottisol ® Benefits<br />
DOTTIKON ES, with its production site in <strong>Dottikon</strong> (Aargau, Switzerland), is specialized in hazardous chemical reactions and focuses on the exclusive synthesis of fine<br />
chemicals for the pharmaceutical and chemical industry worldwide. The product range of DOTTIKON ES includes active pharmaceutical ingredients (APIs) and<br />
pharmaceutical intermediates as well as in-house-developed, high-value industrial chemicals.<br />
Contact<br />
Europe<br />
<strong>Dottikon</strong> Exclusive Synthesis AG<br />
P.O. Box, 5605 <strong>Dottikon</strong>, Switzerland<br />
Tel +41 56 616 81 11, Fax +41 56 616 81 20<br />
info@dottikon.com, www.dottikon.com<br />
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Dimethyl isosorbide (DMI)<br />
CAS 5306-85-4<br />
Skin penetration Mammalian skin layers<br />
� Horn cells of stratum corneum are connected by<br />
adipose tissue<br />
� <strong>Solubility</strong> enhancing properties of Dottisol ® enable<br />
dissolution of adipose tissue<br />
� Increased polarity of skin layer and surface activity<br />
of Dottisol ® accelerate penetration of active<br />
ingredient into epidermis<br />
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United States of America<br />
<strong>Dottikon</strong> ES America, Inc.<br />
803 W. Trenton Avenue, Suite 1, Morrisville, PA 19067, USA<br />
Tel +1 215 295 2295, Fax +1 215 295 2577<br />
info.us@dottikon.com, www.dottikon.com<br />
� Excellent solubility of active ingredients in<br />
aqueous and organic media<br />
� High purity colorless liquid with neutral odor<br />
� Drug Master File type IV<br />
� Formulation and stability enhancer<br />
� Enhanced penetration of active ingredient<br />
� Less active ingredient needed<br />
� Less skin irritation<br />
Stratum corneum<br />
Basal membrane<br />
Vascular system<br />
Penetration<br />
Active ingredient<br />
Dermis Epidermis
Dottisol ® – <strong>Solubility</strong> <strong>Enhancer</strong><br />
Purity Physical properties<br />
In percent<br />
Appearance Clear, colorless<br />
(99 %<br />
Boiling point 234–242 °C<br />
Flash point >110 °C<br />
Density 1.17 g/cm 3 (25 °C)<br />
Viscosity ~5 mPa. s (25 °C)<br />
Refractive<br />
index<br />
1.46–1.47 (20 °C)<br />
Absorbance 2 years<br />
Packaging<br />
� 25 kg high-density polyethylene<br />
(HDPE) containers<br />
� 200 kg HDPE drums<br />
Samples<br />
� Available upon request
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