Deep Vein Thrombosis: Diagnosis & Treatment Reginald E. Smith ...
Deep Vein Thrombosis: Diagnosis & Treatment Reginald E. Smith ...
Deep Vein Thrombosis: Diagnosis & Treatment Reginald E. Smith ...
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Current Limitations of Existing Drugs<br />
UFH<br />
LMWH<br />
VKAs<br />
Limitations<br />
► Parenteral<br />
► Unpredictable due to<br />
unspecific binding<br />
► Risk of HIT<br />
► Parenteral<br />
► Risk of HIT<br />
► Unpredictable<br />
► Slow onset of action<br />
► Narrow therapeutic window<br />
► Food and drug interactions<br />
Consequences<br />
► Inconvenient for<br />
long term use<br />
► Monitoring of<br />
aPTT required<br />
► Inconvenient and<br />
expensive for long term<br />
use<br />
► Monitoring of platelets<br />
► Regular monitoring and<br />
dose adjustments<br />
► Risk of adverse events<br />
(bleeding)<br />
Fondaparinux<br />
► Parenteral ► Inconvenient and<br />
expensive for long term<br />
use<br />
Lassen MR. Vasc Health Risk Manag. 2008;4(6):1373-86.
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