Deep Vein Thrombosis: Diagnosis & Treatment Reginald E. Smith ...
Deep Vein Thrombosis: Diagnosis & Treatment Reginald E. Smith ...
Deep Vein Thrombosis: Diagnosis & Treatment Reginald E. Smith ...
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Dabigatran etexilate:<br />
a novel direct thrombin inhibitor<br />
N<br />
N<br />
CH 3<br />
N<br />
N<br />
NH<br />
H 3<br />
C<br />
O<br />
O<br />
O<br />
O<br />
N H 2<br />
N<br />
O CH 3<br />
Half life of 12-17 h<br />
~ 80% renally excreted & 6.5% bioavailability<br />
Predictable and consistent anticoagulant effects<br />
Low potential for drug-drug interactions (Verapamil Increases Effect),<br />
no drug-food interactions<br />
No requirement for routine coagulation monitoring<br />
Rapid onset of action (1-4 hrs)
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