Deep Vein Thrombosis: Diagnosis & Treatment Reginald E. Smith ...

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Dabigatran etexilate: a novel direct thrombin inhibitor N N CH 3 N N NH H 3 C O O O O N H 2 N O CH 3 Half life of 12-17 h ~ 80% renally excreted & 6.5% bioavailability Predictable and consistent anticoagulant effects Low potential for drug-drug interactions (Verapamil Increases Effect), no drug-food interactions No requirement for routine coagulation monitoring Rapid onset of action (1-4 hrs)
The RE-LY ® Study: Randomized Evaluation of Long-term anticoagulant therapY Dabigatran Compared to Warfarin in 18,113 Patients with Atrial Fibrillation at Risk of Stroke Connolly SJ., et al. NEJM published online on Aug 30th 2009. DOI 10.1056/NEJMoa0905561 Dabigatran etexilate is in clinical development and not licensed for clinical use in stroke prevention for patients with atrial fibrillation
Page 1 and 2: Deep Vein Thrombosis: Diagnosis & T
Page 3 and 4: Fail or Win 3
Page 6 and 7: Virchow’s Triad and Thrombus Form
Page 8 and 9: Pathophysiology of DVT Most Often
Page 11 and 12: Late Presentation Is Common The Ris
Page 13 and 14: WELLS Scale For Pretest Probability
Page 15 and 16: Sensitivity & Specificity Of D-Dime
Page 17 and 18: Compression Ultrasound Lower Extrem
Page 19 and 20: Deep Vein Clots Are Big Measured In
Page 21 and 22: Pulmonary Embolism 21
Page 23 and 24: Pulmonary Embolism: A Life-threaten
Page 25 and 26: Diagnostic Testing for PE CT Angiog
Page 27 and 28: Acute Pulmonary Embolism R Axis Dev
Page 29: Grade IA Symptomatic Proximal DVT G
Page 32 and 33: Therapy: Do We Need To Anticoagulat
Page 34 and 35: Overlapping Heparins, LMWH or Fonda
Page 36 and 37: Does SYMPTOMATIC Calf DVT Require T
Page 38 and 39: Cancer Associated Thrombosis 38
Page 40 and 41: Treatment Of Cancer Associated Thro
Page 42 and 43: Novel Anticoagulants: The Future of
Page 44 and 45: New Oral Anticoagulant Agents In De
Page 48 and 49: RE-LY ® - study design Atrial fibr
Page 50 and 51: Major bleeding rates 3.50 3.00 2.50
Page 52 and 53: Most common adverse events Dabigatr
Page 54 and 55: RE-COVER TM Trial Design Singledumm
Page 56 and 57: Cumulative risk of first event of m
Page 58 and 59: Dabigatran: How To Measure Effect?
Page 60: Bleeding Management Withhold Dabiga
Page 63 and 64: Rivaroxaban Brand name Xarelto ® ,
Page 65 and 66: Effect of Rivaroxaban On Coagulatio

Deep Vein Thrombosis: Diagnosis & Treatment Reginald E. Smith ...

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