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progression, e.g., to identify the cysteine cathepsins expressed in a given tumor type and<br />
stage as well as in the various constituents <strong>of</strong> the tumor microenvironment at the level<br />
<strong>of</strong> transcripts, proteins and active enzymes; to determine the relevant substrates cleaved<br />
by those cysteine cathepsins; to delineate the respective contribution <strong>of</strong> intracellular and<br />
pericellular proteolysis to malignant progression; and to determine how the cysteine<br />
cathepsins interact within tumor-associated proteolytic networks.<br />
64<br />
l47
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