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Program Director/Principal Investigator (Last, First, Middle): Mahantshetty, U 5 Kinhikar R.A., Deshpande S.S., Mahantshetty U., Sarin R., Shrivastava S.K., Deshpande D.D. 6 Kinhikar R.A., Sharma P.K., Tambe C.M., Mahantshetty U.M., Sarin R., Deshpande D.D., Shrivastava S.K. 7 Bhalavat, R.L., Pathak, K.A., Mahantshetty, U., Jamema, S.V. 8 Swamidas V. Jamema, Sherly Saju, Umesh Mahantshetty, Siddanna Palled, D. D. Deshpande, S. K. Shrivastava. 9 Thyavihally Y.B., Tongaonkar H.B., Srivastava S.K., Mahantshetty U., Kumar P., Raibhattanavar S.G. 10 Jamema, S.V., Saju, S., Mahantshetty, U., Pallad, S., Deshpande, D.D., Shrivastava, S.K., Dinshaw, K.A. operative radiation in advanced (resectable) supraglottic larynx and pyriform sinus cancers: A prospective randomized study HDR brachytherapy combined with 3-D conformal vs. IMRT in left-sided breast cancer patients including internal mammary chain: comparative analysis of dosimetric and technical parameters. Clinical application of a One-Dose MOSFET for skin dose measurements during internal mammary chain irradiation with high dose rate brachytherapy in carcinoma of the breast Brachytherapy boost: A novel approach for epiglottic carcinoma Dosimetric comparison of inverse optimization with geometric optimization in combination with graphical optimization for HDR prostate implants Clinical outcome of 36 male patients with primary urethral carcinoma: A single center experience Dosimetric evaluation of rectum and bladder using image-based CT planning and orthogonal radiographs with ICRU 38 recommendations in intracavitary brachytherapy Surgical Oncology 29(9), 750-756. 2003. Journal of applied Clinical Medical Physics / American College of Medical Physics. Vol 6. Issue 3; 1-12; 2005. Physics in Medicine and Biology Vol. 51, No. 14, 2006. Brachytherapy 6 (3) 212 – 217 2007 Journal of Medical Physics, Vol. 31, No. 2, 89-94, 2006. International Journal of Urology 13 (6) 716 – 720; 2006. Journal of Medical Physics 33 (1) 3-8 2008 Others : 1. S.K.Shrivastava, K.Dinshaw, U.Mahantshetty, R.Engineer, N.Patil, D.Deshpande, H.Tongaonkar Comparing low-dose and High-dose-Rate Intracavitary Brachytherapy in Carcinoma Cervix: Results from a randomized controlled study Int J of Radiat Oncol Biol Physics 66(3): Supp: S42 (abstract 72). 2006. 2. Palled SR, Doddihal HM, Mahantshetty UM. Choledochal Cyst Carcinoma Treated with Stereotactic Radiotherapy Letter to the Editor Clinical Oncology, Volume 18, Issue 2, 153-154; March 2006 3. Nikhilesh G. Patil, Sherly Saju, S.V. Jamema, Umesh Mahantshetty, Sudesh Deshpande, Siddanna Palled, Deepak D. Deshpande, Shyam K. Shrivastava and Ketayun A. Dinshaw Comparative Analysis of CT Based 3D Volumetric Dosimetry and Radiography Based 2D Dosimetry for High Dose Rate Intracavitary Applications. Brachytherapy Volume 5, Issue 2, April- June 2006, Page 99. 4. Shruti M. Velaskar, R. Martha, U. Mahantashetty, J.S.Badakare, S.K.Shrivastava. Use of Indigenous Vaginal dilator in Radiation induced vaginal stenosis. The Indian Journal of Occupational Therapy : Vol. XXXIX : No. 1 (April 2007 - July 2007) 5. Bhalavat RL, Mahantshetty UM, Tole S, Jamema SV. Treatment outcome with low-dose-rate interstitial brachytherapy in earlystage oral tongue cancers. J Cancer Res Ther. 2009: 5 (3); 192-7. 6. Swamidas VJ, Mahantshetty U, Vineeta G, Engineer R, Deshpande DD, Sarin R, Shrivastava SK. Treatment planning of Epithelial Ovarian Cancers using Helical Tomotherapy. J Appl Clin Med Phys. 2009: Oct.7; 10 (4) ;96 – 105. TEXTBOOK CHAPTERS Mahantshetty Umesh, Chada Pranav, Engineer Reena, Shrivastava Shyam Kishore, Dinshaw Ketayun A. Radiotherapy in Ovarian Cancers-Current Status. In: Ovarian Cancer: Contemporary Management. Chitrathara, Shalini Rajaram, Amita Maheshwari, Jaypee Brothers 2008-2009 (ISBN 978-81-8448-539-4) 256-262. Mahantshetty Umesh, Jamema Swamidas, Shrivastava SK. Chapter 9: Applicator Selection, Insertion and Imaging of 3D Image-Based Intracavitary Brachytherapy: The Tata Memorial Hospital Mumbai Experience In : Image Guided Gynecologic Radiation Therapy. A Vishwananthan, C Kirisits, B Erickson and R Poetter, Springer Publications. 2008-2009 (In print) Dinshaw KA, Mahantshetty U, Shrivastava SK, Tongaonkar HB. Oxford Desk Reference – Oncology A Chapter on “Cervical Cancer” T Ajithkumar, N Cook, H Hatcher, A Barrett, M Aapro, Oxford Press 2010 (In print) 04 03 02 01 01 01 D. Research Support S. No IRB No. Role in Brief 1 114/2002 Active Co PI, Involved in recruitment and overall conduct of the trial 2 119/2003 Co PI with active Project Title, IRB Number, Names of PI/Co PI/CI, ONGOING PROJECTS Concomitant chemoradiation in advance stage carcinoma cervix- A phase III Randomised trial. SK Shrivastava, HB Tongaonkar, S Gupta, R Kerkar, A Maheshwari, Mahantshetty U, Engineer R, KA Dinshaw Till Dec. 2009, 705 patients have been randomized. The trial accrual rate, follow-up, DSMSC monitoring and patient compliance are within acceptable standards. Accrual completion by Dec. 2010. Interim analysis currently ongoing Concomitant chemoradiation versus neo-adjuvant chemotherapy and surgery in the management stage II carcinoma cervix- A phase III Date of Acceptance / Starting Jan. 2003 Jan. 2003 Funding body / Association With National / Intl Body / TMH TMH DAE-CTC Page 2 Continuation Format Page
Program Director/Principal Investigator (Last, First, Middle): participation esp. in the treatment of patients in the standard arm (CT+RT) 3 158/2004 Active Co PI, Involved in Recruitment and overall conduct of the study 4 205/2004 Active Co PI, Involved in Recruitment and overall conduct of the trial 5 248/2005 Co-PI Assisting in the accrual of patients 6 253/2005 IAEA – 13041/R PI , coordinating with IAEA for the patient accrual, treatment and overall conduct of the study 8 281/2006 Co-PI, will be involved in the conduct and co-ordinate Randomised trial, S Gupta, HB Tongaonkar,SK Shrivastava, Maheshwari, S (Ghosh) Laskar, Mahantshetty U, Engineer R, KA Dinshaw Till Dec. 2009, 198 patients have been randomized. The trial accrual rate is slow, DSMSC monitoring and patient compliance are within acceptable standards. A phase II randomized Trial comparing Intensity Modulated radiation therapy with conventional Radiation therapy in Stage II B carcinoma cervix. SK Shrivastava, U Mahantshetty, D Deshpande, S (Ghosh) Laskar, Engineer R, Dinsahw KA, RA Kinhikar, Jemima SV, S Gupta, Tongaonkar HB Till Dec. 2009, 120 patients have been randomized. The trial accrual rate has improved this year with 32 pts recruited this year. The follow-up, DSMSC monitoring and patient compliance are within acceptable standards. Now, planned to further increase the accrual rate. Para-aortic Lymph Node Staging and Evaluation of Treatment Outcome by 18 F-fluorodeoxyglucose Positron Emission Tomography (FDG-PET) in Advanced Cancer Cervix. KA Dinshaw, SK Shrivastava, A Samuel, U Mahantshetty, HB Tongaonkar, R Kerkar, A Maheshwari, S (Ghosh) Laskar, Engineer R. Till Dec. 2009, 103 patients have been recruited. The accrual has been completed. Currently, follow-up PET scans ongoing. The follow-up, DSMSC monitoring, investigations and patient compliance are within acceptable standards. Initial report submitted for MD Thesis (Dr Mahesh Upasani) A Randomized Clinical Study to compare Radical Concomitant Chemoradiation against radical radio therapy as treatments of Carcinoma uterine Cervix Stages Ib-IIIb in HIV Infected patients. SK Shrivastava, S Ghosh Laskar, J P Agarwal, Engineer R, Mahantshetty U, A Alahari, S Gupta, R Kelkar, KA Dinshaw Accrual Closed. Final analysis awaited from IAEA Optimizing treatment of carcinoma cervix cancer using radiotherapy and analysis of virally associated cellular resistance. Mahantshetty U, Shrivastava SK, Engineer Reena, Deshpande DD, Jemima SV, Kedar Deodhar, RF Chinoy, Dinshaw KA, This is an IAEA-Multicentric 2x2 trial. Out of 596 till Dec 2009, 254 patients have been randomized from our centre with 100 pts recruited this year. The trial accrual rate, follow-up and patient compliance are within acceptable standards. Accrual will close at 600 pts. Initial report being presented at ASTRO 2010. A study of the chemo-adjuvant potential of curcumin in human cervical carcinomas and the signaling pathways involved. Shrivastava SK, Dinshaw KA, Tongaonkar HB, S Chiplunkar, PM Parikh, S Gupta Mahantshetty U, Engineer Reena, RA Kerkar, A Maheshwari, R Kelkar, D Bandyopadhyay, T Teni, GB Maru June 2004 May 2004 Varian Medical Systems TMH 2005 IAEA Multicentric 2005 IAEA/WCI Approved in May 2006 Now again in Dec 2007 DBT The study was started in June 2008. Till Dec. 2009, 76 patients have been recruited. The follow-up, DSMSC monitoring and patient compliance are within acceptable standards. 10 461/2007 PI Quantitative Estimation and Evaluation of HPV 16/18 DNA in Pretreatment, Post Treatment and Follow-up Evaluatyion in Carcinoma Cervix II-IIIB treated with Radical radiation or chemoradiation therapy: An Observational Study. U Mahantshetty, Sk Shrivastava, KA Dinshaw, R.S Kelkar, R Engineer, HB Tongaonkar, S Chiplunkar, A Maheshwari, R Kerkar, S Patil, T Teni July 2009 Intramural (to be started) 11 598/2008 PI Waiver of RT Charges at ACTREC: pending till Dec. 2009 12 601/2008 As PI Applied for Funding Awaiting response and then start 13 588/2008 Co-PI , assisting in the accrual of patients This study was considered for Intramural funding and has been granted 1 st year funding. HEC clearance in March 2009. The study funds transferred to ACTREC under Dr T Teni. Will start accrual now. Whole abdominal Radiation Therapy with image guided total peritoneal IMRT in Advanced Epithelial Ovarian Cancers- Phase II study Mahantshetty U, Shrivastava SK, Tongaonkar HB, Engineer R, Maheswari A, Kerkar R, Goel V, Gupta S, Menon H, Prabhash K, Jamema SV, Devi R, Purandare N, Deshpande DD. A International Study on MRI Guided Brachytherapy in locally Advanced Cervical Cancers (EMBRACE) Endorsed by GEC-ESTRO Mahantshetty U, Shrivastava SK, Engineer R, Merchant NH, Tongaonkar HB, Kerkar R, Maheshwari A, Gupta S, Prabash K, Deodhar K, Deshpande DD, Dinshaw KA Phase II study evaluating role of Tomotherapy based Intensity Based Modulated Radiotherapy and Brachytherapy in post surgery recurrent carcinoma cervix Engineer R, Shrivastava SK, Mahantshetty U, Goel V, Tongaokar HB, Kerkar R, Maheswari A, Menon H, Devi R, Master Z, Patkar S, Thakur Page 3 2008 Ongoing Approved in Nov 2008 Oct 2008 To be applied for funding and start Ongoing Continuation Format Page
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BIOGRAPHICAL SKETCH A. Personal Statement Briefly describe ...

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