Use of GXII Platform in HT Screening for Mammalian ... - PerkinElmer

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Challenges to Process Analytics: Automation and Throughput Requirement Rapid turnaround Sample demand Improvements to the Process From 5 - 10 days to
Tools for HT Product Characteristic Screening Tests Standard Methods HT Screening Tools Analytical scale sample purification PhyTips / Semi automated (10`s of samples) GXII / Sciclone Platform & PhyTips (48 to 96 samples) % Purity SDS PAGE (10 samples) GXII / Sciclone Platform (100 to 200 samples) Charge analysis - Agrose Gel, CZE (10 to 24 samples) To review use of GXII Glycan profile Aggregation MALDI TOF MS, HPLC & UPLC (4 to 8 samples) HPLC & UPLC (24 samples) GXII / Sciclone Platform UPLC GXII / Sciclone Platform © Lonza Biologics plc 2012 slide 13
Page 1 and 2: PerkinElmer User Meeting - 12 June
Page 3 and 4: Bio-pharmaceutical Products • The
Page 5 and 6: Reduce Timelines for Recombinant Pr
Page 7 and 8: Automated Miniature Bioreactors - I
Page 9 and 10: Purification Optimisation Robot - I
Page 11: Applications of HT Screening Antibo
Page 15 and 16: GXII / Sciclone as Part of the HT A
Page 17 and 18: Phase I - PA HT Platform on the Ben
Page 19 and 20: Rapid Product Quality SDS PAGE Trad
Page 21 and 22: Rapid Product Quality • Early int
Page 23 and 24: Glycan Profiling Workflow • A mic
Page 25 and 26: Case Study: Glycan by MS/HPLC and G
Page 27: Acknowledgments • Monica Barredo

Use of GXII Platform in HT Screening for Mammalian ... - PerkinElmer

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