Use of GXII Platform in HT Screening for Mammalian ... - PerkinElmer
Use of GXII Platform in HT Screening for Mammalian ... - PerkinElmer
Use of GXII Platform in HT Screening for Mammalian ... - PerkinElmer
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L<strong>in</strong>k<strong>in</strong>g Islands <strong>of</strong> Automation to Form an<br />
“Archipelago”<br />
Productivity<br />
assessment<br />
1<br />
Transfect<br />
Generate<br />
stable<br />
pools<br />
Clon<strong>in</strong>g by<br />
FACS<br />
(1 cell/well)<br />
Automated<br />
colony<br />
identification<br />
(ICCMS)<br />
Automated<br />
colony<br />
sampl<strong>in</strong>g<br />
Automated<br />
Colony<br />
pick<strong>in</strong>g<br />
Screen<strong>in</strong>g, DoE,<br />
optimisation<br />
Bioreactor studies<br />
etc.<br />
Stability <strong>for</strong><br />
manufactur<strong>in</strong>g<br />
WEEK 17*<br />
choose<br />
lead cell<br />
l<strong>in</strong>e<br />
3<br />
Fed-batch productivity & PQ, 9 cell l<strong>in</strong>es<br />
Fed-batch<br />
productivity<br />
assessment<br />
© Lonza Biologics plc 2012 slide 20<br />
2<br />
WEEK ~9*<br />
choose<br />
candidate<br />
cell l<strong>in</strong>es<br />
Shak<strong>in</strong>g 96-DWP<br />
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