Use of GXII Platform in HT Screening for Mammalian ... - PerkinElmer

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Scope of Presentation • Bio-pharmaceutical Products • Role of Process Analytics • Why Speed Up Process Analytics Support for Product Development? • Challenges to Process Analytics • GXII / Sciclone as Part of the HT Analytics Screening Platform • Summary © Lonza Biologics plc 2012 slide 2
Bio-pharmaceutical Products • Therapeutic protein production by recombinant–DNA technology. • Genes encoding the protein are transfected into a target cell line. • Transfected cells are generally cloned and adapted to secrete large amounts of product during a fermentation culture. • The primary, secondary and tertiary structure of the protein product is controlled by the cell. • The product is purified from the cell culture medium. © Lonza Biologics plc 2012 slide 3
Page 1: PerkinElmer User Meeting - 12 June
Page 5 and 6: Reduce Timelines for Recombinant Pr
Page 7 and 8: Automated Miniature Bioreactors - I
Page 9 and 10: Purification Optimisation Robot - I
Page 11 and 12: Applications of HT Screening Antibo
Page 13 and 14: Tools for HT Product Characteristic
Page 15 and 16: GXII / Sciclone as Part of the HT A
Page 17 and 18: Phase I - PA HT Platform on the Ben
Page 19 and 20: Rapid Product Quality SDS PAGE Trad
Page 21 and 22: Rapid Product Quality • Early int
Page 23 and 24: Glycan Profiling Workflow • A mic
Page 25 and 26: Case Study: Glycan by MS/HPLC and G
Page 27: Acknowledgments • Monica Barredo

Use of GXII Platform in HT Screening for Mammalian ... - PerkinElmer

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