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Use of GXII Platform in HT Screening for Mammalian ... - PerkinElmer

Use of GXII Platform in HT Screening for Mammalian ... - PerkinElmer

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Why Screen <strong>for</strong> Glycosylation Dur<strong>in</strong>g<br />

Early Process Development?<br />

Glycans regulate:<br />

•Biological activity<br />

•Half-life<br />

For MAbs:<br />

Fc region Oligos <strong>in</strong>teract<br />

with other immune<br />

system prote<strong>in</strong>s, mak<strong>in</strong>g<br />

them essential <strong>for</strong><br />

antibody function.<br />

© Lonza Biologics plc 2012 slide 24

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