Schneider's first rank symptoms \(1\)

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Non-neurological S/E (1) Adverse Reaction Frequency Comment General Sedation “Torpor” (Ataraxy) Dry mouth ++ +++ + Esp. with low potency drugs Blurred vision Constipation Urinary difficulties Impaired sexual function Weight gain + + + + +++ Conventionally viewed as peripheral anticholinergic effects. Some probably include adrenergic actions May have endocrine component Cardiovascular Incr. Heart rate Hypotension +++ ++ Not clinically significant Can be fatal – caution with early exposure to low potency drugs ECG changes ++ Quinidine-like effect : rarely causes ventricular tachyarrhythmias particularly with thioridazine
Non-neurological S/E (2) Adverse Reaction Frequency Comment Endocrine Hyperprolactinaemia +++ Universal effect (except clozapine) - Galactorrhoea - Hyper/hypoglycaemia Gynaecomastia Hyper/hypoglycaemia Inappropriate ADH Rare + Rare Rare Rare Rarely clinically significant Hepatic Function Impaired liver ++ Transient changes common. Jaundice esp. with chlorpromazine Dermatologic al Skin rashes -Erythematous -Urticarial -Contact Photosensitivity Pigmentation ++ ++ Rare Rare ++ ? Rare Especially with chlorpromazine Can result in serious burning. Temp. less important than brightness Infrequently reported nowadays
Page 1 and 2: Schizophrenia Dr. Edwin CS Yu Consu
Page 3 and 4: Aetiology (1) Genetics: Relationshi
Page 5 and 6: Aetiology (3) Personality: • Schi
Page 7 and 8: Clinical picture
Page 9 and 10: Schneider’s first rank symptoms (
Page 11 and 12: Hallucinations Auditory hallucinati
Page 13 and 14: Delusions (2) • Delusion of perse
Page 15 and 16: Disorders of affect • Blunted aff
Page 17 and 18: Negative symptoms • Chronic • P
Page 19 and 20: Onset • Variable modes of onset
Page 21 and 22: Good prognostic factors • Evidenc
Page 23 and 24: Long-term outcome • Tendency to r
Page 25 and 26: Post-schizophrenic depression (1)
Page 27 and 28: Drug treatment of schizophrenia Neu
Page 29 and 30: Drug treatment • Continuous thera
Page 31 and 32: Typical antipsychotics • Choose t
Page 33 and 34: Atypical antipsychotics • Most of
Page 35 and 36: Clozapine • Clozapine is a unique
Page 37 and 38: Depot antipsychotics • Modecate d
Page 39: As general practitioners, it is imp
Page 43 and 44: Acute dystonia (1) Presentation Aff
Page 45 and 46: Parkinsonism (1) Feature Posture :
Page 47 and 48: Akathisia Feature Anxious, tense ex
Page 49 and 50: Tardive Dyskinesia (2) Presentation

Schneider's first rank symptoms \(1\)

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