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Septic shock – Monitoring methods, parameters, end points

Septic shock – Monitoring methods, parameters, end points

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Rivers et al NEJM, 2001, 345, 1368-1377<br />

« Early Goal-directed Therapy »<br />

263 patients :<br />

. Severe sepsis<br />

. <strong>Septic</strong> <strong>shock</strong><br />

ECG, SpO 2 , UF<br />

Art cath , CVC<br />

Standard treatment<br />

n = 133<br />

CVP 8 -12 mmHg<br />

MAP > 65 mmHg<br />

UF > 0.5 ml/kg/h<br />

For 6 hours<br />

Protocol<br />

n = 130<br />

idem + ScvO 2 > 70%<br />

SaO 2 > 93%<br />

HT> 30 %

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