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Mathematical model of the human colon - Inria

Mathematical model of the human colon - Inria

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The Human Colon Motivation <strong>Ma<strong>the</strong>matical</strong> <strong>model</strong> Validation framework Perspectives and Conclusions<br />

Premises<br />

The microbiota can be<br />

functionally represented<br />

The <strong>colon</strong> can be defined as a<br />

high-rate system:<br />

High biomass concentration:<br />

formation <strong>of</strong> aggregates in<br />

<strong>the</strong> mucus<br />

Resistance to hydrodynamic<br />

forces<br />

In spite <strong>of</strong> its geometry, <strong>the</strong>re<br />

are some factors that produce<br />

mixing:<br />

Peristaltic movement<br />

Shed <strong>of</strong> epi<strong>the</strong>lial cells<br />

Gas production<br />

The <strong>colon</strong> can be represented<br />

by a series <strong>of</strong> chemostats

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