Mathematical model of the human colon - Inria
Mathematical model of the human colon - Inria
Mathematical model of the human colon - Inria
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The Human Colon Motivation <strong>Ma<strong>the</strong>matical</strong> <strong>model</strong> Validation framework Perspectives and Conclusions<br />
Obstacles and Alternatives<br />
Phenonema not well defined, e.g<br />
transport <strong>of</strong> components between<br />
<strong>the</strong> subsystems, rheology<br />
Difficulty <strong>of</strong> measurements<br />
Availability <strong>of</strong> data is limited<br />
Limitations for in vitro<br />
experiments: most <strong>of</strong> <strong>the</strong> bacteria<br />
are uncultured<br />
Many studies are based on <strong>the</strong><br />
microbiota in fecal matter<br />
Microsensors and FISH in<br />
mucus: spatial distribution<br />
Studies on artificial systems<br />
Study <strong>of</strong> state observers<br />
Bayesian approach for parameter<br />
estimation<br />
16SrRNA and FISH techniques<br />
in vivo <strong>model</strong>s: inoculated axenic<br />
rodents, biopsy in mucus