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Mathematical model of the human colon - Inria

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The Human Colon Motivation <strong>Ma<strong>the</strong>matical</strong> <strong>model</strong> Validation framework Perspectives and Conclusions<br />

Obstacles and Alternatives<br />

Phenonema not well defined, e.g<br />

transport <strong>of</strong> components between<br />

<strong>the</strong> subsystems, rheology<br />

Difficulty <strong>of</strong> measurements<br />

Availability <strong>of</strong> data is limited<br />

Limitations for in vitro<br />

experiments: most <strong>of</strong> <strong>the</strong> bacteria<br />

are uncultured<br />

Many studies are based on <strong>the</strong><br />

microbiota in fecal matter<br />

Microsensors and FISH in<br />

mucus: spatial distribution<br />

Studies on artificial systems<br />

Study <strong>of</strong> state observers<br />

Bayesian approach for parameter<br />

estimation<br />

16SrRNA and FISH techniques<br />

in vivo <strong>model</strong>s: inoculated axenic<br />

rodents, biopsy in mucus

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