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Mathematical model of the human colon - Inria

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The Human Colon Motivation <strong>Ma<strong>the</strong>matical</strong> <strong>model</strong> Validation framework Perspectives and Conclusions<br />

Modelling <strong>of</strong> invitro homoacetogenesis<br />

Identification<br />

Vector <strong>of</strong> data collected:<br />

y(t i ) = y m (t i ,θ ∗ ) + ε i , i = 1,...,n t , (15)<br />

ε i ∼ N(0,Σ). (16)<br />

Maximum likelihood:<br />

π y (y s |θ) (17)<br />

Criterion 1: Least Squares on<br />

normalized errors (C1)<br />

Criterion 2: Σ from <strong>the</strong> experimenetal<br />

data (C2)<br />

Criterion 3: Σ unknown for synchronous<br />

data (C3)<br />

Criterion 4: Σ unknown for<br />

non-synchronous data (C4)

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